Extracellular Vesicles — A Versatile Biomaterial

The Year 2022 in biomaterials research: A perspective from the editors of six leading journals

“…AHM also received an increasing number of submissions on the use of extracellular vesicles and exosomes, either within biomaterials or as biomaterials themselves. To reflect this trend AHM commissioned a Special issue on “Extracellular Vesicles—A Versatile Biomaterial” edited by Juliane Nguyen (University of North Carolina at Chapel Hill, USA) and Gregor Fuhrmann (Friedrich‐Alexander‐University Erlangen‐Nürnberg, Germany) 23 . Examples of the most accessed articles in this issue are the review by Anika Nagelkerke et al (University of Groningen, The Netherlands) on liposomes and extracellular vesicles as drug delivery systems 24 and the application of those as siRNA delivery vehicles, employing extracellular vesicle—liposome hybrid nanoparticles, reported by the group of Pieter Vader (University Medical Center Utrecht, The Netherlands) 25 .…”

“…To reflect this trend AHM commissioned a Special issue on "Extracellular Vesicles-A Versatile Biomaterial" edited by Juliane Nguyen (University of North Carolina at Chapel Hill, USA) and Gregor Fuhrmann (Friedrich-Alexander-University Erlangen-Nürnberg, Germany). 23 Examples of the most accessed articles in this issue are the review by Anika Nagelkerke et al (University of Groningen, The Netherlands) on liposomes and extracellular vesicles as drug delivery systems 24 and the application of those as siRNA delivery vehicles, employing extracellular vesicle-liposome hybrid nanoparticles, reported by the group of Pieter Vader (University Medical Center Utrecht, The Netherlands). 25 In the same area, but not in this special issue was also the article from the group of Patrick S. Doyle (MIT, Harvard Medical School, Boston) which shows quantitative and multiplex detection of extracellular vesicle-derived Micro-RNA using rolling circle amplification within encoded hydrogel microparticles.…”

In Situ-Crosslinked Zippersomes Enhance Cardiac Repair by Increasing Accumulation and Retention

“…Extracellular vesicles (EVs) -lipid vesicles secreted by cells -provide a middle ground between cellular and synthetic approaches. EVs contain many of the components typically found in their parent cells including proteins, RNAs, growth factors, and chemokines [1][2][3][4] but, in contrast to cells, are easier to handle, store, and ship. Their small size, physicochemical properties, and low immunogenicity permit deep tissue penetration, facilitate intercellular communication, and mediate tissue regeneration [5][6][7][8][9][10][11] .…”

Plant-derived nanovesicles: Further exploration of biomedical function and application potential

“…EVs have been extensively studied in different scientific fields, such as drug delivery systems (DDSs), disease treatment, and clinical diagnosis, and have been applied in the treatment of cancer, cardiovascular diseases, neurodegenerative diseases, and tissue repair 3 , 4 . EVs are physiologically active and can avoid phagocytosis of the reticuloendothelial system, penetrate biomembrane barriers, and prolong the half-life of drugs 5 , 6 . However, the clinical potential of mammalian cell-derived extracellular vesicles (MEVs) is plagued by the complex extraction process, low yield, and high cost.…”