Extracellular Vesicles as Therapeutic Tools for the Treatment of Chronic Wounds

Bray, Eric R.; Oropallo, Alisha; Grande, Daniel; Kirsner, Robert S.; Badiavas, Evangelos V.

doi:10.3390/pharmaceutics13101543

Cited by 35 publications

(26 citation statements)

References 213 publications

(270 reference statements)

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“…To explore the therapeutic potential of ADSC-EVs more accurately, BMSC-EVs and ADSC-EVs were applied, respectively to diabetic wounds, and the results demonstrated that ADSC-EVs possess the more potent pro-angiogenic activity and can promote the wound healing of diabetic ulcers ( 13 ). Considering the availability of adipose tissue and fewer ethical concerns of EVs, emerging skin regenerative studies tend to focus on ADSC-EVs to better transform to future clinical trials ( 128 ).…”

Section: Preclinical and Clinical Studies Of Adsc-evs For Skin Regene...mentioning

confidence: 99%

The Therapeutic Role of ADSC-EVs in Skin Regeneration

et al. 2022

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Large skin defects caused by burns, unhealing chronic wounds, and trauma, are still an intractable problem for clinicians and researchers. Ideal skin regeneration includes several intricate and dynamic stages of wound repair and regeneration of skin physiological function. Adipose-derived stem cells (ADSCs), a type of mesenchymal stem cells (MSCs) with abundant resources and micro-invasive extraction protocols, have been reported to participate in each stage of promoting skin regeneration via paracrine effects. As essential products secreted by ADSCs, extracellular vesicles (EVs) derived from ADSCs (ADSC-EVs) inherit such therapeutic potential. However, ADSC-EVs showed much more clinical superiorities than parental cells. ADSC-EVs carry various mRNAs, non-coding RNAs, proteins, and lipids to regulate the activities of recipient cells and eventually accelerate skin regeneration. The beneficial role of ADSCs in wound repair has been widely accepted, while a deep comprehension of the mechanisms of ADSC-EVs in skin regeneration remains unclear. In this review, we provided a basic profile of ADSC-EVs. Moreover, we summarized the latest mechanisms of ADSC-EVs on skin regeneration from the aspects of inflammation, angiogenesis, cell proliferation, extracellular matrix (ECM) remodeling, autophagy, and oxidative stress. Hair follicle regeneration and skin barrier repair stimulated by ADSC-EVs were also reviewed. The challenges and prospects of ADSC-EVs-based therapies were discussed at the end of this review.

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Section: Preclinical and Clinical Studies Of Adsc-evs For Skin Regene...mentioning

confidence: 99%

The Therapeutic Role of ADSC-EVs in Skin Regeneration

et al. 2022

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“…As discussed before, MSC-EVs could hold great promise as they are gradually recognized as effective drug delivery systems that can overcome earlier drug-stability and immunological issues [ 136 ]. This is of importance in corneal scarring/fibrosis, where the homeostatic nature of wound healing entailing of inflammation, proliferation and regeneration is disrupted [ 153 ]; meanwhile, MSC-EVs could induce a potent wound-healing process under the hypoxic and inflammatory conditions that typically characterize chronic injury [ 154 ].…”

Section: Can We Utilize Extracellular Vesicles In Treatments Regiment...mentioning

confidence: 99%

“…Clinical trials have confirmed the efficacy and safety of MSCs in wound treatment [ 154 ], but their technical utility is limited [ 155 ]. The literature on pre-clinical in vivo and in vitro studies evaluating MSC-EVs in promoting wound healing has been reported.…”

Section: Can We Utilize Extracellular Vesicles In Treatments Regiment...mentioning

confidence: 99%

Extracellular Vesicles in Corneal Fibrosis/Scarring

Yeung

Boychev

Farhat

et al. 2022

IJMS

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Communication between cells and the microenvironment is a complex, yet crucial, element in the development and progression of varied physiological and pathological processes. Accumulating evidence in different disease models highlights roles of extracellular vesicles (EVs), either in modulating cell signaling paracrine mechanism(s) or harnessing their therapeutic moiety. Of interest, the human cornea functions as a refractive and transparent barrier that protects the intraocular elements from the external environment. Corneal trauma at the ocular surface may lead to diminished corneal clarity and detrimental effects on visual acuity. The aberrant activation of corneal stromal cells, which leads to myofibroblast differentiation and a disorganized extracellular matrix is a central biological process that may result in corneal fibrosis/scarring. In recent years, understanding the pathological and therapeutic EV mechanism(s) of action in the context of corneal biology has been a topic of increasing interest. In this review, we describe the clinical relevance of corneal fibrosis/scarring and how corneal stromal cells contribute to wound repair and their generation of the stromal haze. Furthermore, we will delve into EV characterization, their subtypes, and the pathological and therapeutic roles they play in corneal scarring/fibrosis.

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“…Some cells such as MSCs are known to promote skin repair, thus MSC-derived exosomes can be used to induce skin regeneration. 94 Additionally, some milk-derived exosomes could prevent skin aging and help in wound repairing. 95 This shows that skin therapeutic agent-loaded exosomes can aid in the treatment of skin damage.…”

Section: Exosome-based Ddss In Treatment Of Various Diseasesmentioning

confidence: 99%