Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Yap, Tami; Pruthi, Neha; Seers, Christine A.; Belobrov, Simone; McCullough, Michael; Celentano, Antonio

doi:10.3390/ijms21041197

Cited by 27 publications

(25 citation statements)

References 89 publications

(176 reference statements)

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“…The challenging paradigm is due to the worse prognosis and high mortality rate, combined with the lack of better perspectives (65). Differential microRNA (miRNA) expression profile in OSCCrelated EVs have been documented both in vitro and in clinical experiments (66,67). Hunsaker et al (68) tried to identify the role of melatonin in oral carcinoma-associated EVs (including the exosomes) and impact on microRNA (miRNA) content in various oral cancer cell lines.…”

Section: Exosome-melatonin Therapy Changes the Neoplastic Immunosuppression Status In Hepatocellular And Oral Squamous Cell Carcinomasmentioning

confidence: 99%

Exosomes and Melatonin: Where Their Destinies Intersect

et al. 2021

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Cell-to-cell communication is a broad and complex process associated with regular stimuli to maintain healthy cell interactions. One of the agents capable of cellular communication is known as an exosome, a subset of extracellular vesicles (EVs) released by the cell membrane. The exosome contains a wide range of functional proteins, mRNAs and miRNAs, which have the potential to interact with healthy or diseased cells in the body. On the other hand, melatonin also acts as a cellular communicator, produced and released by the pineal gland in a circadian way and also, non-circadian melatonin is derived from the mitochondria of all normal cells. In addition to exhibiting antioxidant, anti-inflammatory, anti-tumor and anti-aging activities, melatonin has recently been studied by its influence on exosomes. This review summarizes the relationship between exosomes and melatonin in various pathological processes. There is robust evidence that their combination ameliorates inflammation, ischemia-reperfusion injury, hepatic metabolic disturbance, cancer immunosuppression status, degenerative processes like chronic kidney disease, vascular calcification, ageing, ischemic brain injury, neurodegenerative diseases, obesity, colitis, wound healing and even embryonic development. Association of exosomes and melatonin represent a promising therapeutic tool, capable of interfering with basic molecular processes, such as oxidative stress and the inflammatory cascade, which support many pathophysiological aspects of diseases.

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Section: Exosome-melatonin Therapy Changes the Neoplastic Immunosuppression Status In Hepatocellular And Oral Squamous Cell Carcinomasmentioning

confidence: 99%

Exosomes and Melatonin: Where Their Destinies Intersect

et al. 2021

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“…21 Importantly, miRNAs also are found in extracellular vesicles that protect them from nucleolytic attack and increase their stability in biological fluids, making them potential biomarkers in plasma or saliva (either as apoptotic bodies, microvesicles produced by membrane budding, or exosomes originating from the endosomal apparatus). 22,23 A study by MacLellan et al 24 described the utility of analyzing the serum levels of miRNA in predicting the malignant potential of high-risk oral lesions (OSCC and dysplastic lesions). A more recent study by Yap et al 25 used quantitative PCR (qPCR) to profile the expression of five miRNAs from oral rinses in a cohort of patients with OSCC and OPML.…”

Section: Assessing the Risk Associated With Oral Potentially Malignant Lesionsmentioning

confidence: 99%

Section: Assessing the Risk Associated With Oral Potentially Malignant Lesionsmentioning

confidence: 99%

Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Saidak¹,

Lailler²,

Testelin³

et al. 2021

Ann Surg Oncol

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Background Oral squamous cell carcinoma (OSCC) is the most frequent type of tumor arising from the oral cavity. Surgery is the cornerstone of the treatment of these cancers. Tumor biology has long been overlooked as an important contributor to the outcome of surgical procedures, but recent studies are challenging this concept. Molecular analyses of tumor DNA or RNA provide a rich source of information about the biology of OSCC. Methods We searched for relevant articles using PubMed. We examined in particular the prospect of applying molecular methods for minimally invasive exploration of OSCC biology. Results We examined five potential applications of genomics to the surgical management and study of OSCC: i) assessing oral potentially malignant lesions; ii) tumor staging prior to surgery; iii) predicting postoperative risk in locally advanced tumors; iv) measuring minimal residual disease and optimizing the longitudinal monitoring of OSCC; and v) predicting the efficacy of medical treatment. Conclusions Genomic information can be harnessed in order to identify new biomarkers that could improve the staging, choice of therapy and management of OSCC. The identification of new biomarkers is awaited for better personalization of the surgical treatment of OSCC.

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“…Several studies have analyzed the expression of CD9 in oral squamous cell carcinoma [58][59][60][61]; however, few studies have focused on oral pre-malignant lesions with CD9 antigen expression. We found studies on CD9 expression in epithelial dysplasia [62,63], and a systematic review from the previous year [64] on extracellular vesicles in oral squamous cell carcinoma and oral potentially malignant disorders. There have been studies on the extracellular vesicles in oral saliva of patients with periodontal diseases [65,66], as well as oral squamous cell carcinoma [67].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

Čēma

Dzudzilo

Kleina

et al. 2021

Cancers

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The aim of this study was to determine whether and how pan-CD44 protein expression in leukoplakia tissues correlates with positive SolCD44 test presence and their role in oral leukoplakia. SolCD44 and total protein expression in saliva were determined using an OncAlert® Oral Cancer Rapid test. Comparison of paired associations of total protein, SolCD44, mean number of CD44 expressed epithelial layers in leukoplakia tissue, and macrophages below the basement membrane between control group and patients with leukoplakia showed statistically significant results (p < 0.0001). It is shown that the total protein indicates low or elevated risk of possible malignant transformation processes in leukoplakia. Statistically significant differences between higher total protein level and clinical forms of oral leukoplakia (p < 0.0001), as well as CD44-labeled epithelial cell layer decrease (p < 0.0001), were found. This possibly points to the onset of the stemness loss in leukoplakia tissue. CD9 antigen expression in the exosomes of the oral epithelium explained the intercellular flow of SolCD44 and other fluids in the leukoplakia area. We conclude that the OncAlert® Oral Cancer Rapid test is a valuable screening method in daily clinical practice, in terms of complementing clinical diagnostics methods and to assess the potential for early malignancy.

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Extracellular Vesicles in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Cited by 27 publications

References 89 publications

Exosomes and Melatonin: Where Their Destinies Intersect

Exosomes and Melatonin: Where Their Destinies Intersect

Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues

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