Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Shaimardanova, Alisa A.; Solovyeva, Valeriya V.; Chulpanova, Daria S.; James, Victoria; Kitaeva, Kristina V.; Rizvanov, Albert A.

doi:10.4103/1673-5374.266908

Cited by 76 publications

(59 citation statements)

References 133 publications

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“…For example, in-depth study of circRNAs in exosomes present in blood or cerebrospinal fluid can contribute to reveal the underlying mechanisms of the development of neuropsychiatric disorders 36 . Furthermore, miRNAs carried by serum exosomes can be used for the diagnosis and prognosis of spinal cord injury (SCI) 37 . Likewise, by evaluating the expression profile of miRNAs in endometrial cancer (EC) and urine-derived exosomes from suspected patients, it was found that differentially expressed miRNAs can be used as biomarkers for EC diagnosis.…”

Section: Classificationmentioning

confidence: 99%

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang¹,

Bi²,

Huang³

et al. 2020

IJN

802

624

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Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body's physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.

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Section: Classificationmentioning

confidence: 99%

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang¹,

Bi²,

Huang³

et al. 2020

IJN

802

624

View full text Add to dashboard Cite

show abstract

“…Although cumulative evidence have been shown that both microvesicles and exosomes exhibit reparative and regenerative properties, the exosomes are the most well-characterized and widely used vesicle for cell-free-based therapy [ 48 ]. In addition, they are less heterogeneous than the microvesicles [ 77 ] and do not elicit acute immune rejection nor confer risk for tumor formation [ 45 ]; thus, the exosomes have been considered a useful candidate for the treatment of several diseases, including neurodegenerative disorders [ 54 , 58 , 71 , 78 , 79 ].…”

Section: Brief History Of Extracellular Vesicles Discoverymentioning

confidence: 99%

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Araldi

D’Amélio

Vigerelli

et al. 2020

Cells

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The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.

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“…For example, it was shown that EVs derived from NK cells (NKEVs) are able to exert a stimulating effect on PBMCs, as well as increase the fraction of CD56 + NK cells, which suggests a potential support for cancer therapy [ 168 ]. However, clinical trials conducted with such EVs indicated that native EVs are not sufficient to exert the desired effect in vivo; but, considering their safety when administered, as well as their ability to modify and target a specific cell, EVs make an interesting tool for the treatment of cancer [ 120 ], neurodegenerative [ 169 ], inflammatory and autoimmune diseases [ 170 ].…”

Section: Vaccinesmentioning

confidence: 99%

Current Trends in Cancer Immunotherapy

et al. 2020

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The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have needed to invent new ways of overcoming the problems encountered during treatments, and have also made important discoveries pertaining to fundamental issues relating to the emergence and development of malignant neoplasms. Understanding the basics of the human immune system interactions with tumor cells has enabled new cancer immunotherapy strategies. The initial successes observed in immunotherapy led to new methods of treating cancer and attracted the attention of the scientific and clinical communities due to the prospects of these methods. Nevertheless, there are still many problems that prevent immunotherapy from calling itself an effective drug in the fight against malignant neoplasms. This review examines the current state of affairs for each immunotherapy method, the effectiveness of the strategies under study, as well as possible ways to overcome the problems that have arisen and increase their therapeutic potentials.

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Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Cited by 76 publications

References 133 publications

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Current Trends in Cancer Immunotherapy

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