Extracellular Vesicles of Pseudomonas: Friends and Foes

Henríquez, Tania; Falciani, Chiara

doi:10.3390/antibiotics12040703

Cited by 6 publications

(5 citation statements)

References 91 publications

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“…Characterization of the EVs proteome of Shigella flexneri 2A has identified at least 148 proteins and components in common with the EVs of Gram-negative bacteria [ 43 ]. OMV production has been widely described in Gram-negative bacteria, including the EVs of Shigella dysenteriae [ 44 ], H. pylori [ 45 ], P. aeruginosa [ 46 , 47 ], K. pneumoniae [ 40 , 48 ], E. coli [ 49 , 50 ] and other bacteria of this group [ 29 , 39 ]. The presence of molecules from the periplasmic space and the outer membrane has been demonstrated, which is a distinctive feature of OMVs.…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

Peregrino,

Castañeda-Casimiro,

Vázquez-Flores

et al. 2024

IJMS

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Pathogenic bacteria have several mechanisms to evade the host’s immune response and achieve an efficient infection. Bacterial extracellular vesicles (EVs) are a relevant cellular communication mechanism, since they can interact with other bacterial cells and with host cells. In this review, we focus on the EVs produced by some World Health Organization (WHO) priority Gram-negative and Gram-positive pathogenic bacteria; by spore-producing bacteria; by Mycobacterium tuberculosis (a bacteria with a complex cell wall); and by Treponema pallidum (a bacteria without lipopolysaccharide). We describe the classification and the general properties of bacterial EVs, their role during bacterial infections and their effects on the host immune response. Bacterial EVs contain pathogen-associated molecular patterns that activate innate immune receptors, which leads to cytokine production and inflammation, but they also contain antigens that induce the activation of B and T cell responses. Understanding the many effects of bacterial EVs on the host’s immune response can yield new insights on the pathogenesis of clinically important infections, but it can also lead to the development of EV-based diagnostic and therapeutic strategies. In addition, since EVs are efficient activators of both the innate and the adaptive immune responses, they constitute a promising platform for vaccine development.

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Section: Extracellular Vesiclesmentioning

confidence: 99%

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

Peregrino,

Castañeda-Casimiro,

Vázquez-Flores

et al. 2024

IJMS

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“…A varying fraction of lipids within biofilms is associated with extracellular vesicles [114]. The various typologies and mechanisms of production of extracellular vesicles have recently been reviewed in [23].…”

Section: Lipids Lipopolysaccharide (Lps) and Other Biofilm Componentsmentioning

confidence: 99%

Interactions of Neutrophils with the Polymeric Molecular Components of the Biofilm Matrix in the Context of Implant-Associated Bone and Joint Infections

Campoccia,

Ravaioli,

Mirzaei

et al. 2023

IJMS

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In the presence of orthopedic implants, opportunistic pathogens can easily colonize the biomaterial surfaces, forming protective biofilms. Life in biofilm is a central pathogenetic mechanism enabling bacteria to elude the host immune response and survive conventional medical treatments. The formation of mature biofilms is universally recognized as the main cause of septic prosthetic failures. Neutrophils are the first leukocytes to be recruited at the site of infection. They are highly efficient in detecting and killing planktonic bacteria. However, the interactions of these fundamental effector cells of the immune system with the biofilm matrix, which is the true interface of a biofilm with the host cells, have only recently started to be unveiled and are still to be fully understood. Biofilm matrix macromolecules consist of exopolysaccharides, proteins, lipids, teichoic acids, and the most recently described extracellular DNA. The latter can also be stolen from neutrophil extracellular traps (NETs) by bacteria, who use it to strengthen their biofilms. This paper aims to review the specific interactions that neutrophils develop when they physically encounter the matrix of a biofilm and come to interact with its polymeric molecular components.

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“…Disruption of the crosslink between the peptidoglycan and the outer membrane, resulting in their separation. Moreover, the buildup of peptidoglycan fragments or misfolded proteins has been observed in the literature, resulting in bulking pressure on the outer membrane and, eventually, OMVs freedom ( Henriquez and Falciani, 2023 ). The population-sensing quinolone signaling (PQS) molecules induce OMVs production by inserting into the outer membrane and mediating its packing and transport, and when PQS in the outer leaflets is cumulative thought to change curvature ( Florez et al, 2017 ).…”

Section: Types Formations and Extraction Of Mvsmentioning

confidence: 99%

Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles

Xiao,

Li,

Yang

2023

Front. Microbiol.

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Bacteria-host interaction is a common, relevant, and intriguing biological phenomena. The host reacts actively or passively to the bacteria themselves, their products, debris, and so on, through various defense systems containing the immune system, the bacteria communicate with the local or distal tissues of the host via their own surface antigens, secreted products, nucleic acids, etc., resulting in relationships of attack and defense, adaptation, symbiosis, and even collaboration. The significance of bacterial membrane vesicles (MVs) as a powerful vehicle for the crosstalk mechanism between the two is growing. In the recent decade, the emergence of MVs in microbial interactions and a variety of bacterial infections, with multiple adhesions to host tissues, cell invasion and evasion of host defense mechanisms, have brought MVs to the forefront of bacterial pathogenesis research. Whereas MVs are a complex combination of molecules not yet fully understood, research into its effects, targeting and pathogenic components will advance its understanding and utilization. This review will summarize structural, extraction and penetration information on several classes of MVs and emphasize the role of MVs in transport and immune response activation. Finally, the potential of MVs as a therapeutic method will be highlighted, as will future research prospects.

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Extracellular Vesicles of Pseudomonas: Friends and Foes

Cited by 6 publications

References 91 publications

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities

Interactions of Neutrophils with the Polymeric Molecular Components of the Biofilm Matrix in the Context of Implant-Associated Bone and Joint Infections

Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles

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