Extracellular vesicles: Their functions in plant–pathogen interactions

Zhou, Qingfeng; Ma, Ke; Hu, Huanhuan; Xing, Xiaolong; Huang, Xuan; Gao, Hang

doi:10.1111/mpp.13170

Cited by 41 publications

(27 citation statements)

References 99 publications

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“…However, P-EVs are not well explored compared to the vesicles derived from animal cells; hence a comprehensive understanding of the biomolecular cargo composition of P-EVs is still absent [ 70 , 76 ]. The type of cargo of P-EVs is influenced by the condition under which they are secreted or synthesized [ 70 , 76 ]. In this section, we focus on the biological compositions of P-EVs.…”

Section: Biological Composition and Function Of P-evsmentioning

confidence: 99%

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Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

et al. 2022

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Background Many eukaryote cells produce membrane-enclosed extracellular vesicles (EVs) to establish cell-to-cell communication. Plant-derived EVs (P-EVs) contain proteins, RNAs, lipids, and other metabolites that can be isolated from the juice, the flesh, and roots of many species. Methods In the present review study, we studied numerous articles over the past two decades published on the role of P-EVs in plant physiology as well as on the application of these vesicles in different diseases. Results Different types of EVs have been identified in plants that have multiple functions including reorganization of cell structure, development, facilitating crosstalk between plants and fungi, plant immunity, defense against pathogens. Purified from several edible species, these EVs are more biocompatible, biodegradable, and extremely available from many plants, making them useful for cell-free therapy. Emerging evidence of clinical and preclinical studies suggest that P-EVs have numerous benefits over conventional synthetic carriers, opening novel frontiers for the novel drug-delivery system. Exciting new opportunities, including designing drug-loaded P-EVs to improve the drug-delivery systems, are already being examined, however clinical translation of P-EVs-based therapies faces challenges. Conclusion P-EVs hold great promise for clinical application in the treatment of different diseases. In addition, despite enthusiastic results, further scrutiny should focus on unravelling the detailed mechanism behind P-EVs biogenesis and trafficking as well as their therapeutic applications.

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Section: Biological Composition and Function Of P-evsmentioning

confidence: 99%

“…P-EVs have been shown to contain small non-coding RNAs such as micro RNAs (miRNAs) [ 76 ]. The miRNAs are present in most P-EVs, such as in ginger, grape, grapefruit, lemon, broccoli, and apple [ 58 ].…”

Section: Biological Composition and Function Of P-evsmentioning

confidence: 99%

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

et al. 2022

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“…In addition to plant extracellular vesicles for plant growth and development, defense responses, and plant-microbe symbiosis ( Regente et al, 2017 ; Rutter and Innes, 2018 ; Chukhchin et al, 2019 ; Ivanov et al, 2019 ; Zhou et al, 2021 ), plant extracellular vesicles have attracted attention for their potential roles in human health and disease. For example, extracellular vesicles extracted from edible fruits and vegetables have antioxidant functions, and strawberry- and blueberry-derived exosome-like nanoparticles prevent oxidative stress in human mesenchymal stromal cells and endothelial cells ( De Robertis et al, 2020 ; Logozzi et al, 2021 ; Perut et al, 2021 ).…”

Section: Extraction Of Plant Extracellular Vesiclesmentioning

confidence: 99%

Plant extracellular vesicles: A novel bioactive nanoparticle for tumor therapy

Tan

Luo

et al. 2022

Front. Pharmacol.

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Extracellular vesicles are tiny lipid bilayer-enclosed membrane particles, including apoptotic bodies, micro vesicles, and exosomes. Organisms of all life forms can secrete extracellular vesicles into their surrounding environment, which serve as important communication tools between cells and between cells and the environment, and participate in a variety of physiological processes. According to new evidence, plant extracellular vesicles play an important role in the regulation of transboundary molecules with interacting organisms. In addition to carrying signaling molecules (nucleic acids, proteins, metabolic wastes, etc.) to mediate cellular communication, plant cells External vesicles themselves can also function as functional molecules in the cellular microenvironment across cell boundaries. This review introduces the source and extraction of plant extracellular vesicles, and attempts to clarify its anti-tumor mechanism by summarizing the current research on plant extracellular vesicles for disease treatment. We speculate that the continued development of plant extracellular vesicle-based therapeutic and drug delivery platforms will benefit their clinical applications.

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“…g ., in a multicellular organism) 5,6 , as well as between cells of different organisms ( e . g ., during interactions of cells with different pathogens) 7,8 . Two of the most conserved cell-to-cell signaling pathways are paracrine, secretion of signals that are perceived by neighboring cells, and juxtacrine, communication between cells connected via tunneling nano tubes, gap junctions, or plasmodesmata 9–11 .…”

Section: Introductionmentioning

confidence: 99%

“…The exchange of signals between cells is thought to have evolved as part of a mechanism to control cell density (e.g., quorum sensing; QS) 1,2 , and/or as part of a response mechanism to changes in environmental conditions (e.g., in cells living in a biofilm) 3,4 . Cell-tocell communication can occur between cells of the same species or organism (e.g., in a multicellular organism) 5,6 , as well as between cells of different organisms (e.g., during interactions of cells with different bacterial or fungal pathogens) 7,8 . Two of the most conserved cell-to-cell signaling pathways are paracrine, secretion of signals that are perceived by neighboring cells, and juxtacrine, communication between cells connected via tunneling nano tubes, gap junctions, or plasmodesmata [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

ROS are evolutionary conserved cell-to-cell signals

Fichman

Rowland

Oliver

et al. 2022

Preprint

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Cell-to-cell communication is fundamental to multicellular organisms, as well as to unicellular organisms living in a microbiome. It is thought to have evolved as a stress- or quorum-sensing mechanism in unicellular organisms. A unique cell-to-cell communication mechanism that uses reactive oxygen species (ROS) as a signal (termed the ROS wave) was recently identified in flowering plants. This process is essential for systemic signaling and plant acclimation to stress and can spread from a small group of cells to the entire plant within minutes. Whether this signaling process is found in other organisms is however unknown. Here we report that a ROS-mediated cell-to-cell signaling process, like the ROS wave, can be found in ferns, mosses, multicellular and unicellular algae, amoeba, and mammalian cells. We further show that this process can be triggered by extracellular H2O2 application and blocked by inhibition of NADPH oxidases, and that at least in unicellular algae growing as a lawn on an agar plate, it communicates important stress-response signals between cells. Taken together, our findings suggest that an active process of cell-to-cell ROS signaling, like the ROS wave, evolved before unicellular and multicellular organisms diverged. This mechanism could have communicated an environmental stress signal between cells and coordinated the acclimation response of cells living in a community. The finding of a signaling process, like the ROS wave, in mammalian cells further contributes to our understanding of different diseases and could impact the development of new drugs that target, for example cancer or heart disease.

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Extracellular vesicles: Their functions in plant–pathogen interactions

Cited by 41 publications

References 99 publications

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

Plant extracellular vesicles: A novel bioactive nanoparticle for tumor therapy

ROS are evolutionary conserved cell-to-cell signals

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