Extracorporeal Haemocorrection and Its Impact on Free-Radical Oxidation and Antioxidant Defense in Abdominal Sepsis

Petrov, V.; Petrova, Maja; Sviridov, Sergey V.; Surmenev, Dmitrij V.

doi:10.21292/2078-5658-2018-15-1-40-45

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…They demonstrate that methods of extracorporeal detoxification, including HF, are effective for endotoxicosis management in patients with SAP that is signified by the reduced intensity of systemic inflammatory response and lower complication rate [ 57 , 102 – 106 ]. Positive effect of HF in intestine barrier dysfunction caused by destructive pancreatitis is related to the improvement of the cytokine status owing to the removal of proinflammatory cytokines and antioxidant stress inhibition [ 107 , 108 ].…”

Section: Hemofiltration and Hemodiafiltration In Severe Acute Pancreatitismentioning

confidence: 99%

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

et al. 2020

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Questions regarding the application of extracorporeal detoxification to patients with severe acute pancreatitis have been considered. Hemodialysis, the historically first method of extracorporeal detoxification for such patients, has been also described in the review. Appropriateness of using renal replacement therapy methods and among them continued renal replacement therapy has been shown. Hemofiltration and hemodiafiltration technologies are described in detail including different modes of their application and the possibility of using various types of filters. Available data on hemofiltration for patients with severe acute pancreatitis have been analyzed. Great attention is paid to the unsolved aspects of hemofiltration in severe acute pancreatitis such as determining renal and extrarenal indices; time of starting hemofiltration; selection of volume replacement modes and a buffer system; procedure duration; anticoagulation measures, defining criteria to assess the adequacy of hemofiltration, state severity, and organ dysfunction degree. Further multicenter investigations are necessary to be able to assess the efficacy of the hemofiltration procedures on the basis of the thoroughly worked out and pathogenically grounded protocol using adequate control methods taking into consideration endogenic intoxication phases and intensity of the multiple organ failure syndrome.

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Section: Hemofiltration and Hemodiafiltration In Severe Acute Pancreatitismentioning

confidence: 99%

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

et al. 2020

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Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

Masolitin,

Protsenko,

Tyurin

et al. 2024

Vestn. anesteziol. reanimatol.

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Introduction . The choice of the method and time of initiation of extracorporeal detoxification (ECD) in septic shock (SSh) complicated by acute kidney injury (AKI) is a debatable problem.The objective was to evaluate the influence of various ECD tactics on the dynamics of markers of systemic endotoxicosis and acid-base status (ABS) in patients with SSh complicated by AKI.Materials and methods. Study included 57 patients. Group 1 – 36 patients used continuous veno-venous hemodiafiltration (CVVHDF) for urgent indications. Group 2 – 21 patients used early combined ECD (LPS-sorption and CVVHDF). A comparative analysis of the main laboratory parameters between the groups was performed.Results. Early combined ECD made it possible to reduce the concentration of leukocytes by the 3rd day of therapy from 20.6 to 12.5 ·109/l (39.3 %) from the initial level in group 2, and from 22.2 to 19.15·109/l (13.7 %) in group 1 ( p=0.04); C-reactive protein by the 5th day of therapy from 284 to 145 mg/l (48.9 %) in group 2, and from 299.3 to 199.8 mg/l (33.2 %) in group 1 ( p=0.02); procalcitonin by the 5th day of therapy from 7.2 to 1.6 ng/ml (77.8 %) in group 2, and from 7.8 to 4.45 ng/ml (42.9 %) in group 1 ( p= 0.02); pH by the 3rd day of therapy from 7.17 to 7.37 in group 2, and from 7.19 to 7.27 in group 1 (p =0.04); IL-6 level by the 5th day of therapy from 764.9 to 361.7 pg/ml (52.7 %) in group 2, and from 700.1 to 542.5 pg/ml (22.5 %) in group 1 (p=0.007).Conclusions. Early combined ECD more quickly reduces markers of systemic endotoxicosis and eliminates impairment of ABS, than CVVHDF.

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Extracorporeal Haemocorrection and Its Impact on Free-Radical Oxidation and Antioxidant Defense in Abdominal Sepsis

Cited by 2 publications

References 3 publications

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

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