Extracorporeal Photopheresis as Graft-versus-Host Disease Prophylaxis: A Randomized Controlled Trial

Ali, Maryan; Gedde‐Dahl, Tobias; Osnes, Liv; Perrier, Flavie; Veierød, Marit B.; Tjønnfjord, Geir E.; Iversen, Per Ole

doi:10.1016/j.jtct.2023.02.023

Cited by 6 publications

(3 citation statements)

References 63 publications

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“…The mechanism underlying ECP’s therapeutic activity is still being studied. 19 , 31 , 33 However, several theories attempt to explain the impact of ECP on the collected lymphocytes. ECP primarily affects the T-cell section of immunological action.…”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…Lastly, alterations in the function of immune cells and the recipient’s cytokine environment occur after the reinfusion of the treated cells. 19 , 33 APCs subsequently phagocytose circulating apoptotic cells. This results in an increase in regulatory T cells and a decrease in proinflammatory cytokines.…”

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

“…8 Overall, nearly 30% to 50% of individuals undergoing transplantation encounter acute GVHD. 19,20 Acute GVHD frequency following allogeneic HSCT varies based on factors such as the level of HLA difference, the cutting-edge age of the recipient or donor, the advanced malignant condition at transplantation, the donor hematopoietic cell source, and other factors. 8 Staging systems have been verified and proven effective in predicting mortality.…”

Section: Destruction Of the Target Tissues By Effector T Cellsmentioning

confidence: 99%

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The Role of Extracorporeal Photopheresis in the Management of Graft Versus Host Disease: Narrative Review

Berhan,

Damtie,

Almaw

et al. 2024

ITT

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Hematopoietic stem cell donation is a method used to treat both blood-related and non-blood-related malignancies. Graft-versus-host disease is a potentially life-threatening complication that can occur following a stem cell transplant from a donor. This happens after the transplanted grafts attack the recipient’s body as foreign cells, causing significant morbidity and mortality. Clinically, this condition can be classified as acute or chronic based on onset and pathophysiology. This review aims to provide an overview of recent studies on extracorporeal photopheresis as a treatment strategy option for graft-versus-host-diseased patients. It will explain how it treats graft-versus-host disease, summarize its promising effects, and provide future recommendations for its use in treating this illness. Extracorporeal photopheresis is used to treat graft-versus-host disease by collecting and separating white blood cells from the patient. This blood is fractionated into different parts, and white blood cells undergo treatment with 8-methoxy psoralen, a photoactivable drug, before exposure to ultraviolet light A. Lastly, the cells that have been treated are reinfused into the recipient’s body. It prompts the programmed cell death of lymphocytes and the engulfment of cellular debris by host antigen-presenting, leading to a subsequent rise in T regulatory cells. However, more experimental and randomized controlled studies are required to identify the best patient selection requirements, environments, and treatment regimens for graft-versus-host disease.

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Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%

Section: Pathophysiology and Classification Of Gvhdmentioning

confidence: 99%