Extracranial Carotid Artery Disease

Lim, Siew‐Na; Chang, Yu-Ching; Lin, Shinn-Kuang

doi:10.7863/ultra.15.03070

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…It is known that brain infarction occurs with atherosclerotic stenosis and thrombosis of the carotid arteries (CA) in approximately 40 % of cases [2,19,23]. Given the high frequency and emphasizing the importance of atherosclerotic CA lesions in the development of cerebral disorders, some authors view it as a separate nosological unit, referring to the term "International Carotid Artery Disease" [17,23]. The authors dispute this because of the peculiarities of the geometric configuration of the CA bifurcation.…”

Section: ю и кузыкmentioning

confidence: 99%

Features of the pathomorphological structure of the aterosclerotic plaques of carotid aterosclerosis

Kuzyk

2019

Patologìâ

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A-research concept and design; B-collection and/or assembly of data; C-data analysis and interpretation; D-writing the article; E-critical revision of the article; F-final approval of the article Carotid arteriosclerosis is a recognized leader among causes of ischemic disorders of the cerebral circulation. It is known that brain infarction occurs with atherosclerotic stenosis and thrombosis of the carotid arteries in approximately 40 % of cases. The peculiar geometry of carotid bifurcation creates conditions for the development of atherosclerotic plaques. The aim of the work is determination of pathomorphological features of the structure of atherosclerotic plaques in carotid atherosclerosis. Materials and methods. Histological, histochemical and immunohistochemical studies of surgical material in 680 patients were performed. Results. On the basis of pathomorphological analysis of the plaque in carotid AS they can be divided into complicated and uncomplicated. The first type is atheromatous unstable plaques with the prevalence of foci of atheromatosis, lympho-macrophage infiltration, intraplaque hemorrhage, necrosis of fibrous elements and edema. Immunohistochemically they are characterized by high expression of MMP-9 in macrophages and lymphocytes with degradation of type I collagen in the surface and deep layers of the plaque coating and its replacement by type III collagen (P < 0.05). The second type of plaque is stable uncomplicated with the advantage of fibrosis, hyalinosis and petrification. Immunohistochemical structure of plaques was collagen type I, expression of collagen type III was low, expression of MMP-9 was moderate (P < 0.05). Conclusions. High expression of MMP-9 in carotid atherosclerosis in macrophage-lymphocytic infiltrates in atheromatosis and neovascularization sites was found to result in degradation of type I collagen with its replacement by type III collagen. Such pathomorphological changes underlie plaque instability-the development of intraplaque hemorrhages, ulcers with embolic complications. Synthesis of collagen type I with low expression of type III collagen and MMP-9 has been found to determine the basis of the structure of fibro-muscular plaques. This ensures their hemodynamic stability and stable vascular stenosis.

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Section: ю и кузыкmentioning

confidence: 99%

Features of the pathomorphological structure of the aterosclerotic plaques of carotid aterosclerosis

Kuzyk

2019

Patologìâ

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“…[6] However, the role of carotid ultrasound in evaluating the blood flow between the prestenting and poststenting phases has, to the best of our knowledge, not been reported or validated in stroke patients with carotid stenosis.…”

Section: Introductionmentioning

confidence: 99%

Is carotid sonography a useful tool for predicting functional capabilities in ischemic stroke patients following carotid artery stenting?

Lin

Su²,

Chang

et al. 2017

Medicine

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Extracranial Carotid Atherosclerosis and Acute Ischemic Stroke in a Tertiary Hospital in Burkina Faso

Dabilgou¹,

Dravé²,

Kyelem³

et al. 2019

WJNS

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Objective: To determine the prevalence and risk factors of carotid atherosclerosis among ischemic stroke patients in a tertiary hospital in Burkina Faso. Methodology: This was a descriptive and analytical retrospective study of patients admitted at neurology department of Yalgado Ouedraogo University Teaching Hospital with ischemic stroke and cerebral large vessel atherosclerosis in the period from January 1, 2012 to December 31, 2016. Results: The prevalence of extracranial carotid atherosclerosis was 23.9%. The mean age of patients was 63.5 years (Range 31-90 years). The study population included 65% of men and 35% of women. Hypertension was the most common vascular risk factor (75.6%). Stroke was mostly located in the anterior circulation in 23.9%. Low HDL-C was present in 52% of patients. The majority of plaque was homogeneous (85.2%). Plaque were located in carotid bulbar artery (38.5%) followed by common carotid artery (28.2%) and extracranial internal carotid artery (18.6%). According to cerebral lesion, plaque was bilateral in 45.5%, ipsilateral in 42.3% and contralateral in 12.1% of cases. Tight stenosis was found in 30.1% of patients. There was a significant link between male gender and tight stenosis (p = 0.004). Aspirin was the most antiplatelet therapy used (95.5%). Statin therapy was used in 91% of patients. The mean duration of hospitalization was 12.5 days with a mortality rate of 7.1%. Conclusions: Our study showed that extra carotid atherosclerosis was the most common cause of ischemic stroke in Burkina Faso. Man gender was most represented than women.

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Extracranial Carotid Artery Disease

Abstract: Occlusive carotid artery disease is not uncommon among Chinese patients who have had an acute critical hemispheric infarction. Older age is the factor most significantly correlated with a poor outcome, and occlusive carotid disease is the factor most significantly correlated with death.

Cited by 3 publications

References 27 publications

Features of the pathomorphological structure of the aterosclerotic plaques of carotid aterosclerosis

Features of the pathomorphological structure of the aterosclerotic plaques of carotid aterosclerosis

Is carotid sonography a useful tool for predicting functional capabilities in ischemic stroke patients following carotid artery stenting?

Extracranial Carotid Atherosclerosis and Acute Ischemic Stroke in a Tertiary Hospital in Burkina Faso

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