Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway

Zhou, Renhong; Chen, Hongjiu; Chen, Junpeng; Chen, Xuemei; Wen, Yu; Xu, Leqin

doi:10.1186/s12906-018-2148-2

Cited by 116 publications

(68 citation statements)

References 36 publications

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“…Euplotin C is a secondary metabolite of the marine ciliate Euplotes crassus that has demonstrated marked cytotoxic effects on human cutaneous melanoma cells via the inhibition of the Erk and Akt pathways ( 136 ). A large diversity of plant extracts have demonstrated promising anticancer properties in various cell lines, such as Libidibia ferrea and Celastrus orbiculatus in colorectal cancer ( 137 , 138 ), Astragalus membranaceus , Anthriscus sylvestris and Vernonia amygdalina in breast cancer cells ( 139 - 141 ), Azadirachta indica in prostate cancer ( 142 ), and Fallopia aubertii and Fallopia convolvulus in cervical cancer cells ( 143 ), and these may represent future sources of leading Akt inhibitors. The usefulness of the natural sources is not limited to oncology.…”

Section: Natural Products Targeting the Akt Pathwaymentioning

confidence: 99%

The Akt pathway in oncology therapy and beyond (Review)

et al. 2018

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Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and division, apoptosis suppression and angiogenesis. Akt protein kinase displays important metabolic effects, among which are glucose uptake in muscle and fat cells or the suppression of neuronal cell death. Disruptions in the Akt-regulated pathways are associated with cancer, diabetes, cardiovascular and neurological diseases. The regulation of the Akt signaling pathway renders Akt a valuable therapeutic target. The discovery process of Akt inhibitors using various strategies has led to the identification of inhibitors with great selectivity, low side-effects and toxicity. The usefulness of Akt emerges beyond cancer therapy and extends to other major diseases, such as diabetes, heart diseases, or neurodegeneration. This review presents key features of Akt structure and functions, and presents the progress of Akt inhibitors in regards to drug development, and their preclinical and clinical activity in regards to therapeutic efficacy and safety for patients.

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Section: Natural Products Targeting the Akt Pathwaymentioning

confidence: 99%

The Akt pathway in oncology therapy and beyond (Review)

et al. 2018

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“…Astragalus membranaceus was first recorded in Shen Nong Ben Cao Jing. Modern pharmacological research suggests the Astragalus membranaceus has positive effects such as improving cardiac function, 6 promoting angiogenesis, 7 regulating blood glucose, 8 being an anti-tumor agent, 9 and increasing immunomodulatory activity. 10 The principle active constituents of Astragalus membranaceus are saponins, flavonoids, and polysaccharides, 11 but it also includes components such as anthraquinones, alkaloids, amino acids, β-sitosterol, and metallic elements.…”

Section: Introductionmentioning

confidence: 99%

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

Tan¹,

Chen²,

Li³

2020

DDDT

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Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM. Astragalus membranaceus is a commonly used Chinese medicinal herb. Previous studies have shown that Astragalus membranaceus has anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus , which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.

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“…Formononetin is a principal isoflavone compound extracted from Radix Astragali , which has long been used to treat cardiovascular diseases in traditional Chinese medicine. For example, formononetin has been reported to be able to reduce intracellular ROS by inhibiting mitogen activated protein kinase 8 phosphorylation ( 28 ); to inhibit breast cancer cell proliferation by regulating the phosphatidylinositol 3-kinase (PI3K)/RAC-α serine/threonine-protein kinase (AKT)/serine/threonine-protein kinase mTOR signaling pathway ( 29 ); to increase adipocyte thermogenesis by modulating peroxisome proliferator-activated receptor-γ activity ( 30 ); or to have neuroprotective effects following traumatic brain injury by increasing microRNA-155 and heme oxygenase-1 expression ( 31 ). Regarding I/R injury, formononetin has been reported to markedly reduce the infarct volume and brain water accumulation in a rat model of I/R injury via activation of the PI3K/Akt signaling pathway ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

2018

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Myocardial infarction is a leading cause of mortality worldwide, and timely blood/oxygen reperfusion may substantially improve the outcome of infarction. However, ischemia/reperfusion (I/R) may cause severe side effects through excess reactive oxygen species generation. To develop novel methods to relieve I/R induced cell damage, the present study used a component of traditional Chinese medicine. In the present study, isolated heart tissue from aged mice and H9C2 cells with chemically-induced aging were used as experimental subjects, and it was demonstrated that formononetin was able to alleviate I/R-induced cell or tissue apoptosis. By applying formononetin to I/R-damaged tissue or cells, it was demonstrated that formononetin was able to enhance autophagy and thus alleviate I/R-induced cell damage. Furthermore, it was observed that I/R was able to inhibit lysosomal degradation processes in aged tissues or cells by impairing the lysosome acidification level, and formononetin was able to reverse this process via the re-acidification of lysosomes. In conclusion, the present study demonstrated that formononetin was able to alleviate I/R-induced cellular apoptosis in aged cells by facilitating autophagy.

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Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway

Cited by 116 publications

References 36 publications

The Akt pathway in oncology therapy and beyond (Review)

The Akt pathway in oncology therapy and beyond (Review)

<p>Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases</p>

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

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