Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

Huang, Zhengxin; Lei, Yingfeng; Huang, Xin

doi:10.3892/mmr.2018.9544

Cited by 18 publications

(12 citation statements)

References 32 publications

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“…Isoflavones are classified as both phytoestrogens and selective estrogen receptor modulators [ 31 ]. Additionally, increasing evidences demonstrate that phytoestrogens were considered to protect against several cardiovascular diseases, such as ischemic injury and atherosclerosis [ 32 , 33 ]. Therefore, as an isoflavone, Sop may play a protective role in heart disease.…”

Section: Discussionmentioning

confidence: 99%

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy

Gao

et al. 2020

Bioscience Reports

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Aim: The study aims to evaluate protective effects of sophoricoside (Sop) on cardiac hypertrophy. Meanwhile, The potential and significance of clinical transformation of Sop should be broadened and it should be firmly supported as an attractive drug for the treatment of pathological cardiac hypertrophy and heart failure. Methods: Using the phenylephrine (PE)-induced neonatal rat cardiomyocytes (NRCMs) hypertrophy model, the potent protection of Sop against cardiomyocytes enlargement was evaluated. The function of Sop was validated in mice received transverse aortic coarctation (TAC) or sham surgery. At one week after TAC surgery, mice were treated with Sop for the following 4 weeks, the hearts were harvested after echocardiography examination.Results: Our study revealed that Sop significantly mitigated TAC-induced heart dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis. Mechanistically, Sop treatment induced a remarkable activation of AMPK/mTORC1-autophagy cascade following sustained hypertrophic stimulated. Importantly, the protective effect of Sop was largely abolished by the AMPKα inhibitor Compound C, suggesting an AMPK activation-dependent manner of Sop function on suppressing pathological cardiac hypertrophy. Conclusion: Sop ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy. Hence, Sop might be an attractive candidate for the treatment of pathological cardiac hypertrophy and heart failure.

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Section: Discussionmentioning

confidence: 99%

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy

Gao

et al. 2020

Bioscience Reports

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“…DBD is the most typical formula for supplying both Qi and blood in TCM. Radix Hedysari is a frequently prescribed herb in clinic for benefiting Qi as Astragali Radix but has higher quantity of formononetin than Astragali Radix [ 18 , 19 ]. Moreover, some studies have reported the effect of Radix Hedysari on anti-fibrosis, anti-apoptosis, and anti-oxidation in rat heart [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro

Chang

Guo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The risk of radiation-induced heart damage (RIHD) is a growing concern since recent advances in radiation therapy (RT) for cancer treatments have significantly improved the number of survivors. Radiation-induced myocardial fibrosis (RIMF) is the final pathological condition of RIHD and main change leading to serious cardiovascular complications following RT. The aim of this study was to investigate the effect of ultrafiltration extract of Radix Angelica Sinensis and Radix Hedysari (RAS-RH) on the proliferation, apoptosis, and reactive oxygen species (ROS) of cardiac fibroblasts after X-irradiation in vitro. The RAS-RH extract was from the Danggui Buxue decoction (DBD) in TCM. Primary cardiac fibroblasts were irradiated with 1 Gy X-ray to evaluate the effect of RAS-RH on the expression levels of cell proliferation, apoptosis, ROS, and fibrotic molecules. Our data demonstrated that X-irradiation at 1 Gy resulted in the proliferation of cardiac fibroblasts; RAS-RH attenuated the myocardial fibrosis. Furthermore, X-ray radiation reduced the apoptosis of cardiac fibroblasts; RAS-RH accelerated the apoptosis of these cells after irradiation. In addition, the damage driven by ROS in primary cardiac fibroblasts after irradiation was weakened by RAS-RH and the expression of TGF-β1, Col1, and α-SMA increased after irradiation; RAS-RH decreased the expression of these makers. Overall, these data indicate that low-dose X-ray irradiation boosts myocardial fibrosis, and the effect of RAS-RH protects against fibrosis via attenuating the proliferation and accelerating the apoptosis of myocardial fibroblasts after X-irradiation.

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“…Danggui Buxue is an ancient Chinese decoction which is a famous "yiqi-buxue" herbal preparation containing Radix Angelica Sinensis and Astragalus membranaceus at a ratio of 1 : 5; it appears to have a more potent protective effect compared to its component herb extracts in myocardial ischemia-reperfusion injury [9], and it has an antifibrosis effect in diabetic nephropathy and liver fibrosis [10,11]. Radix Hedysari contains most of the chemical constituents that have antihepatic fibrosis effects, and it has a higher quantity of formononetin than Astragali Radix, which has antiapoptosis and antioxidation effects in the rat heart [12,13]. erefore, we selected Radix Hedysari instead of Astragali Radix to prepare Radix Angelica Sinensis and Radix Hedysari (RAS-RH) ultrafiltration extract from the Danggui Buxue decoction, and we subsequently confirmed that RAS-RH has a correlative protective effect against RIMF [14].…”

Section: Introductionmentioning

confidence: 99%

Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X‐Irradiation‐Induced Cardiac Fibrosis in Rats

Zhao

Chang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Radiation-induced myocardial fibrosis (RIMF) is the main pathological change associated with radiation-induced heart toxicity after radiation therapy in patients with thoracic tumors. There is an antifibrosis effect of Radix Angelica Sinensis and Radix Hedysari (RAS-RH) ultrafiltration extract from Danggui Buxue decoction (DBD) in X-irradiation-induced rat myocardial fibrosis, and this study aimed to investigate whether that effect correlated with apoptosis and oxidative stress damage in primary rat cardiac fibroblasts; further, the potential mechanisms were also explored. In this study, we first found that the RAS-RH antifibrosis effect was associated with the upregulation of microRNA-200a and the downregulation of TGF-β1/smad3 and COL1α. In addition, we also found that the antifibrosis effect of RAS-RH was related to the induction of apoptosis in primary rat cardiac fibroblasts and to the prevention of damage caused by reactive oxygen species (ROS). Interestingly, primary rat cardiac fibroblasts exposed to X-ray radiation underwent apoptosis less frequently in the absence of RAS-RH. Therefore, RAS-RH has the ability to protect against fibrosis, which could be occurring through the induction of apoptosis and the resistance to oxidative stress in rats with X-irradiation-induced myocardial fibrosis; thus, in a model of RIMF, RAS-RH acts against X-irradiation-induced cardiac toxicity.

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Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

Cited by 18 publications

References 32 publications

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy

Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro

Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X‐Irradiation‐Induced Cardiac Fibrosis in Rats

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