Extract of Averrhoacarambola L. (Oxalidaceae) roots ameliorates carbon tetrachloride-induced hepatic fibrosis in rats

Huang, Xiang; Wang, Lihui; Meng, Miaomiao; Zhang, Shijun; Pham, Thi Thai Hoa; Jiang, Liping; Chen, Lixiu; Li, Yuchun; Zhou, Xing; Qin, Luhui; Wu, Xingchun; Zou, Chunlin; Huang, Renbin

doi:10.1016/j.biopha.2019.109516

Cited by 10 publications

(5 citation statements)

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“…28 The A. carambola L. roots extract also showed potential hepatoprotective properties in mice or rats. 29 In the present study, H&E staining of liver tissue indicated that ACFP significantly reduced HFD-induced lipid deposition in livers and attenuated the swelling of hepatocytes and the formation of steatosis. The liver weight, hepatic TG and TCH levels, and steatosis grades were significantly reduced by ACFP treatment.…”

Section: Discussionsupporting

confidence: 61%

“…Averrhoa carambola free phenolic extract (FPEAC) has been reported to lower serum AST and ALT activities, and reduce TG content in the liver, exhibiting potent hepatic steatosis relieving effect partly through inhibiting hepatic lipogenesis 28 . The A. carambola L. roots extract also showed potential hepatoprotective properties in mice or rats 29 . In the present study, H&E staining of liver tissue indicated that ACFP significantly reduced HFD‐induced lipid deposition in livers and attenuated the swelling of hepatocytes and the formation of steatosis.…”

Section: Discussionmentioning

confidence: 99%

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Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

et al. 2023

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BACKGROUNDHyperlipidemia, hepatic steatosis, and hyperglycemia are common metabolic complications of obesity. The objective of the present study is to investigate the in vivo protective effect of Averrhoa carambola L. fruit polyphenols (ACFP) on hyperlipidemia, hepatic steatosis, and hyperglycemia in mice with high‐fat diet (HFD)‐induced obesity and elucidate the mechanisms of action underlying the beneficial effects of ACFP. Thirty‐six specific pathogen‐free male C57BL/6J mice (4 weeks old, weighing 17.1–19.9 g) were randomly divided into three groups and fed with a low‐fat diet (LFD, 10% fat energy), HFD (45% fat energy), or HFD supplemented with ACFP by intragastric administration for 14 weeks. Obesity‐related biochemical indexes and hepatic gene expression levels were determined. The statistical analyses were conducted using one‐way analysis of variance (ANOVA) followed by Duncan's multiple range test.RESULTSThe results showed that the body weight gain, serum triglycerides, total cholesterol, glucose, insulin resistance index, and steatosis grade in the ACFP group decreased by 29.57%, 26.25%, 27.4%, 19.6%, 40.32%, and 40%, respectively, compared to the HFD group. Gene expression analysis indicated that ACFP treatment improved the gene expression profiles involved in lipid and glucose metabolism compared to the HFD group.CONCLUSIONACFP protected from HFD‐induced obesity and obesity‐associated hyperlipidemia, hepatic steatosis, and hyperglycemia by improving lipid and glucose metabolism in mice. © 2023 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

et al. 2023

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“… 20 This oxidative stress leads to peroxidation, which induces detrimental effects on liver, including inflammation (leukocyte infiltration), central vasodilation, hepatocellular fibrosis and necrosis, vascular degeneration, bile duct proliferation, vascular occlusion, cellular hypertrophy, and increased collage depositions. 21 − 23 The mechanism of hepatotoxicity due to oxidative stress involves the imbalance of oxidation and antioxidant systems; thus, liver exposure to CCl 4 increases the production of ROS and reduces the antioxidant capacity. 24 The current study indicated that treatment with CCl 4 on alternate days for a period of 4 weeks led to severe hepatic injury and inflammation in rats.…”

Section: Discussionmentioning

confidence: 99%

Pleurospermum candollei Methanolic Extract Ameliorates CCl₄-Induced Liver Injury by Modulating Oxidative Stress, Inflammatory, and Apoptotic Markers in Rats

et al. 2023

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The main objective of this study was to investigate the hepatoprotective potency of the Pleurospermum candollei methanol extract against CCl4-induced liver damage in rats. HPLC technique was used to estimate the presence of polyphenols in the methanol extract of P. candollei (PCM), while proximate analysis revealed the presence of carbohydrates, lipids, and moisture in the extract. The antioxidant potential of PCM was evaluated by 2,2-diphenylpicrylhydrazyl (DPPH) and reducing power assay, which showed a high percentage of inhibition against free radicals. Hepatotoxicity was induced by carbon tetrachloride (CCl4). CCl4 administration reduced the activity of endogenous antioxidants, whereas it increased the production of nitrites and hydrogen peroxide (H2O2) in rats. Furthermore, the level of hepatic markers in serum was also elevated after CCl4 administration. Moreover, the expression of stress-related markers, proinflammatory mediators, and apoptotic genes was enhanced in CCl4-treated rats. Coadministration of PCM along with CCl4 in rats reduced the levels of free radicals and the above genes to normal levels. CCl4 administration caused histopathological alterations in liver tissues, while cotreatment with PCM mitigated liver injuries. These findings suggest that the methanol extract of P. candollei possesses antioxidant and anti-inflammatory properties and can prevent liver injury. Further pharmacological research will be helpful in determining the effectiveness of P. candollei in humans. Development of FDA-approved plant-based anti-inflammatory drugs can help treat patients and reduce the chances of toxicity.

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“…EACR also considerably reversed the elevation in COL-1a1, α-SMA, TIMP2, TGF-β1, and Smad-2 and -4 mRNA expressions and inhibited α-SMA, TIMP2, TGF-β1, Smad-2, -3, -4, Bax, and caspase-3 levels in liver tissues. Additionally, the extract significantly increased Smad-7 mRNA expression and Smad-7 and Bcl-2 protein levels in the liver ( Huang et al, 2020 ). These findings point to EACR being a promising remedy for liver fibrosis.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Traditional Uses, Phytochemical Constituents and Pharmacological Properties of Averrhoa carambola L.: A Review

et al. 2021

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Averrhoa carambola L. (star fruit) is an edible fruit that is extensively cultivated in southern China, Southeast Asia, India, and northern South America. It has a sweet and juicy taste and is frequently used in fruit salads and fruit platters, as a garnish in cocktail drinks and beverages, or squeezed into juice and served as a beverage. Traditionally, it has been used for treating diabetes and diabetic nephropathy, arthralgia, vomiting, lithangiuria, coughing, hangovers, and chronic paroxysmal headache for thousands of years. Currently, approximately 132 compounds have been isolated from A. carambola. Among them, flavonoids, benzoquinone, and their glycosides have been considered as biologically active substances, which are responsible for various biological activities. Pharmacological studies have revealed that crude extracts or monomeric compounds from A. carambola exhibit multiple bioactivities, such as anti-oxidant, anti-hyperglycemic, anti-obesity, anti-hyperlipidemic, anti-tumor, anti-inflammatory, hepatoprotective, cardioprotective, anti-hypertensive, neuroprotective, and others. Thus, A. carambola is a valuable treatment in Chinese medicine with therapeutic potential for multiple diseases, especially diabetes and diabetes-related diseases. Even though it is a very promising candidate in the development of functional food and the pharmaceutical industry, reports on its bioactivities have only been conducted in vivo and in vitro and there is a gap in research regarding clinical settings and safety. This review therefore provides a comprehensive and systematic overview of current progress on botany, ethnopharmacology, phytochemistry, pharmacology, and toxicity of A. carambola, providing a valuable reference for further developments and applications of A. carambola in the pharmaceutical industry and functional food.

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Extract of Averrhoacarambola L. (Oxalidaceae) roots ameliorates carbon tetrachloride-induced hepatic fibrosis in rats

Cited by 10 publications

References 40 publications

Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

Pleurospermum candollei Methanolic Extract Ameliorates CCl₄-Induced Liver Injury by Modulating Oxidative Stress, Inflammatory, and Apoptotic Markers in Rats

Traditional Uses, Phytochemical Constituents and Pharmacological Properties of Averrhoa carambola L.: A Review

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Extract of Averrhoacarambola L. (Oxalidaceae) roots ameliorates carbon tetrachloride-induced hepatic fibrosis in rats

Cited by 10 publications

References 40 publications

Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

Averrhoa carambola L. fruit polyphenols ameliorate hyperlipidemia, hepatic steatosis, and hyperglycemia by modulating lipid and glucose metabolism in mice with obesity

Pleurospermum candollei Methanolic Extract Ameliorates CCl4-Induced Liver Injury by Modulating Oxidative Stress, Inflammatory, and Apoptotic Markers in Rats

Traditional Uses, Phytochemical Constituents and Pharmacological Properties of Averrhoa carambola L.: A Review

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Pleurospermum candollei Methanolic Extract Ameliorates CCl₄-Induced Liver Injury by Modulating Oxidative Stress, Inflammatory, and Apoptotic Markers in Rats