Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism

Rosewood oil induces sedation and inhibits compound action potential in rodents

“…Essential oils show a variety of pharmacological effects and there are reports indicating a possible inhibitory effect on GABA transaminase (Koo et al, 2003), an enzyme responsible for the GABA degradation, which per se leads to augmentation of GABA levels provoking sedative effects. This possibility could explain our results assuming that GABA potentiates pentobarbital effects which have been already shown (Skolnick et al, 1980;Chu et al, 2007).…”

Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats

“…MAP (mm Hg) pH Pa CO2 (mm Hg) Pa O2 (mm Hg) Glucose (mmol/l) Rectal temperature ( • C) of chronic diseases (Kwok et al, 2005;Tang et al, 2005;Chen et al, 2006;He et al, 2006;Li et al, 2007), immunoregulatory and antitumor activities (Hong et al, 2004;Cao and Lin, 2006;Tang et al, 2006), and sedative effects (Chu et al, 2007). Moreover, it has also been reported to protect against hypoxia/reoxygenation-induced oxidative stress (Zhao et al, 2004(Zhao et al, , 2005.…”

Hypnotic effects and binding studies for GABAA and 5-HT2C receptors of traditional medicinal plants used in Asia for insomnia

“…There are many medicinal plants used traditionally for treatment of insomnia in Asia. The sedative-hypnotic effect of oriental plants such as Ganoderma lucidum (Chu et al, 2007), Schisandra sphenanthera (Huang et al, 2007) and Euphoria longana (Ma et al, 2009a) has been reported. However, scientific evidence and precise mechanism for hypnotic activity of those and other oriental medicinal plants have not been fully investigated.…”