Extract of<i>Rhus verniciflua</i>Bark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis

Park, Dong Ki; Lee, Yang Gi; Park, Hye-Jin

doi:10.1155/2013/879696

Cited by 26 publications

(26 citation statements)

References 31 publications

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“…19 Given that the pullulan hydrogels can let a pharmaceutic to be loaded into the hydrogels without any substantial chemical interaction, we hypothesized that pullulan hydrogels loaded with a certain herbal extract that shows antipruritic and anti-inflammatory effects might further augment the therapeutic effect on AD. 20 Among the herbal candidates, the Rhus verniciflua extract (RVE) was selected for a pharmaceutic to be loaded in the hydrogels in this study. Rhus verniciflua is an Asian tree species of the genus Toxicodendron, native to China and the Indian subcontinent, and cultivated in regions of China, Korea, and Japan.…”

Section: Introductionmentioning

confidence: 99%

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong

Back

et al. 2019

J Biomed Mater Res

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Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with Rhus verniciflua extract (RVE)‐loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier‐transform infrared spectroscopy and an in vitro release assay. Rat pups were randomly divided into two groups: vehicle‐treated (VEH; n = 5) and capsaicin‐treated (n = 15). The latter were given capsaicin subcutaneously at 24 h after birth for AD induction and further divided into three groups (n = 5 per each): not treated (CAP), pullulan hydrogel‐applied (PH), and RVE@PH‐applied (RVE‐PH). The pullulan hydrogel and RVE@PH were topically applied on shoulder lesions for 14 days (from 42 to 56 days after birth). Their phenotypes were compared based on the dermatitis score, epidermal thickness, mast cell infiltration, and serum myeloperoxidase (MPO) activities. The PH group showed significant attenuation in all the aforementioned values compared to the CAP group, suggesting that pullulan hydrogel itself has therapeutic activity against AD. Notably, the attenuations were more potent in the RVE‐PH group than the PH group, indicating that the therapeutic efficacy against AD is augmented by the presence of RVE, a loaded pharmaceutic. Collectively, these results indicate that RVE@PH inhibits AD through exerting the dual roles, that is, the pullulan hydrogel‐mediated physical and RVE‐mediated pharmaceutical actions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2325–2334, 2019.

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Section: Introductionmentioning

confidence: 99%

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong

Back

et al. 2019

J Biomed Mater Res

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“…Where, 0 was absent and 4 was severe pinkish-red color of the ear. Ear thickness was measured before application (challenge) and then pre-and post-application [13].…”

Section: Induction Of Allergic Contact Dermatitis (Acd) With Dinitrofmentioning

confidence: 99%

Inhibitory Effects on Tumor Necrosis Factor Alpha and Interleukin 12 Using Clobetasol Propionate Loaded Tea Tree Oil Nanoemulsion Gel on Animal Model

Alam

Ali

Ansari

et al. 2018

Asian J Pharm Clin Res

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Objective: The main objective of our study is to explore anti-inflammatory activity at its molecular level like tumor necrosis factor alpha (TNF-α), interleukin 12 (IL-12) expression, and histopathological study. Methods:As per solubility/miscibility of clobetasol propionate (CP) with tea tree oil (TTO), surfactant and cosurfactant (S mix ), and water in a ratio of oil:S mix :water (15:35:50) taken in milliliter for the preparation of nanoemulsion. Induced allergic contact dermatitis (ACD) with dinitrofluorobenzene (DNFB) was used for the study. TNF-α and interleukin 12 (IL-12) were estimated with rabbit antimouse TNF-α and rat antimouse IL-12 antibodies in 1% of bovine serum albumin in phosphate buffer.Results: Topical application of CP loaded nanoemulsion gel inhibits ear inflammation and erythema in DNFB-induced ACD in mice and significantly reduces the intracellular edema and infiltration with inflammatory mediator cells involving of mononuclear cells and neutrophils. CP loaded nanoemulsion gel reduces expression of protein level of TNF-α and IL-12.Conclusion: CP loaded nanoemulsion gel confirmed that anti-inflammatory effects showed more rapidly than the placebo and marketed gel preparation. However, the animals treated with placebo nanoemulsion gel showed a somehow comparable reduction of their inflammation during treatment compared with the marketed gel. This effect may be due to anti-inflammatory effect of TTO. This result suggested that anti-inflammatory activity of placebo nanoemulsion gel may be due to TTO present in nanoemulsion as vehicle.

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“…The bark of Rhus verniciflua Stokes (RVS), or Toxicodendron vernicifluum, which belongs to the Anacardiaceae family, is used as food additive and herbal medicine for inflammatory disorders and cancer in Eastern Asia. RVS demonstrates various biological activities, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer effects, and some of which have been verified in vitro [16][17][18][19][20][21][22][23]. At the cellular level, RVS extract and its phenol-rich fraction inhibit lipopolysaccharide (LPS)-induced TNF- and IL-6 expression in RAW264.7 cells, a mouse macrophage cell line [17][18][19]23].…”

Section: Introductionmentioning

confidence: 95%

“…Fisetin, butein, and sulfuretin are the known anti-inflammatory polyphenols present in RVS [24][25][26]. Animals orally administered RVS extract exhibit reduced edema in chemically-induced dermatitis models [18,23], but whether this anti-inflammatory effect occurs in macrophages following oral administration of RVS extract has not been determined. A pharmacokinetic profile study showed that the majority of fisetin, sulfuretin, and other polyphenols in RVS extract were present in blood in their conjugated forms [27].…”

Section: Introductionmentioning

confidence: 99%

Macrophages from Mice Administered <em>Rhus Verniciflua</em> Stokes Extract Show Selective Anti-Inflammatory Activity

Kim¹,

Song²,

Lee³

et al. 2018

Preprint

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The bark of Rhus verniciflua Stokes (RVS) is used as a food additive and herbal medicine for various inflammatory disorders and cancer in Eastern Asia. RVS exerted anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, but whether this effect occurs in macrophages after oral administration has not been determined. We used a thioglycollate-induced peritonitis model to obtain macrophages from mice given RVS. We examined the systemic inflammatory response to intraperitoneal LPS. RVS-treated mice had an increased population of peritoneal exudate cells expressing CD11b and SRA. Increased uptake of Alexa Fluor 488-labeled acetylated lipoprotein was observed in monocyte-derived macrophages from RVS-treated mice. When these cells from the RVS group were stimulated with LPS, the levels of tumor necrosis factor (TNF)- and interleukin (IL)-6 in the supernatant decreased, but the level of IL-12 increased. The surface expression of CD86 was reduced, but surface expression of class II MHC molecules was increased. RVS suppressed the serum levels of LPS-induced TNF- and IL-6. RVS enhanced monocyte differentiation in thioglycollate-induced peritonitis by increasing scavenger receptor expression and activity. Macrophages isolated from mice given RVS responded differently to LPS. These findings demonstrate that RVS confers selective anti-inflammatory activity without causing the overall inhibitory effects on immune cells.

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Extract ofRhus vernicifluaBark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis

Cited by 26 publications

References 31 publications

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Inhibitory Effects on Tumor Necrosis Factor Alpha and Interleukin 12 Using Clobetasol Propionate Loaded Tea Tree Oil Nanoemulsion Gel on Animal Model

Macrophages from Mice Administered <em>Rhus Verniciflua</em> Stokes Extract Show Selective Anti-Inflammatory Activity

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