Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

Liu, Bin; Ge, Jinwen; Cheng, Shaowu; Zheng, Xi-Long; Liao, Jun; He, Chao; Rao, Zheng-qing; Guozuo, Wang

doi:10.1016/j.joim.2020.01.008

Cited by 96 publications

(90 citation statements)

References 24 publications

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“…Nevertheless, further investigations are imperative to elucidate the comprehensive effects of TFR1. Moreover, DMT1 expression was upregulated in rats with cerebral ischemia, and DMT1 inhibitors protected against ferroptosis, reducing cerebral ischemia injury (Lan et al, 2020).…”

Section: Iron-related Proteins and Ismentioning

confidence: 95%

“…Administration of the ferroptosis inhibitors, liproxstatin-1 or ferrostatin-1 (Fer-1), after reperfusion, generated a markedly smaller infarct, thus alleviating cerebral injury (Tuo et al, 2017). Furthermore, studies have revealed that inhibition of ferroptosis can reduce ischemic brain damage in rats, suggesting that ferroptosis mediates the onset and development of IS and exacerbates cerebral injury (Alim et al, 2019;Guan et al, 2019;Lan et al, 2020).…”

Section: Ferroptosis Exerts Profound Regulatory Effects In Cerebral Imentioning

confidence: 99%

“…Recent studies revealed that TFR1 expression is upregulated in the brain during cerebral ischemia in rats, and Naotaifang extract reduces TFR1 expression to inhibit ferroptosis and improve brain injury (Lan et al, 2020). Paradoxically, some studies demonstrated that TFR has the opposite effect.…”

Section: Iron-related Proteins and Ismentioning

confidence: 99%

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Cross Talk Between Ferroptosis and Cerebral Ischemia

et al. 2020

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Recently, ferroptosis has been revealed as a new form of regulated cell death. Distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation. Furthermore, the metabolism of iron, lipids, and amino acids plays a significant regulatory role in ferroptosis, which can be reversed by glutathione peroxidase 4 and ferroptosis suppressor protein 1. Ferroptosis is implicated in the onset and development of numerous neurological diseases. Emerging studies have reported that ferroptosis induces and aggravates brain tissue damage following cerebral ischemia, whereas inhibition of ferroptosis dramatically attenuates induced damage. In this review, we have summarized the mechanistic relationship between ferroptosis and cerebral ischemia, including through iron overload, downregulation of glutathione peroxidase 4, and upregulation of lipid peroxidation. Although considerable attention has been paid to the effect of ferroptosis on cerebral ischemic injury, specific mechanisms need to be experimentally confirmed, including how cerebral ischemia induces ferroptosis and how ferroptosis deteriorates cerebral ischemia.

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Section: Iron-related Proteins and Ismentioning

confidence: 95%

Section: Ferroptosis Exerts Profound Regulatory Effects In Cerebral Imentioning

confidence: 99%

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Cross Talk Between Ferroptosis and Cerebral Ischemia

et al. 2020

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“…Transferrin receptor 1 (TfR1) is a major receptor involved in iron transport to the brain, which plays an important role in maintaining the homeostasis of brain iron and regulating ferroptosis ( Lo et al, 2007 ; Raje et al, 2007 ; Kawabata, 2019 ). The regulation of TfR1 expression as well as its related TfR/Tf endocytic pathway has been identified as a critical event that influences the outcome of ischemic stroke ( Lo et al, 2007 ; Park et al, 2011 ; Lan et al, 2020 ). Interestingly, recent studies have shown that activation of autophagy increases the expression of TfR1 and subsequent intracellular iron ( Qian et al, 2002 ).…”

Section: Crosstalk Between Autophagy and Ferroptosismentioning

confidence: 99%

“…So far, system Xc- has been shown to be involved in ischemic stroke through modulating glutamate transport and GSH synthesis ( Krzyzanowska et al, 2016 ). In middle cerebral artery occlusion rat models, naotaifang extract treatment significantly inhibits ferroptosis by increasing the SLC7A11/GPX4 pathway ( Lan et al, 2020 ). BECN1 is widely identified as an important autophagy modulator in ischemic stroke ( Wang et al, 2014a , b ; Liu et al, 2016 ).…”

Section: Crosstalk Between Autophagy and Ferroptosismentioning

confidence: 99%

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

Liu

Guo

Yan

et al. 2020

Front. Cell. Neurosci.

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Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is a recently discovered iron-dependent cell death pathway associated with the accumulation of lethal reactive lipid species. In the past few years, an increasing number of studies have suggested the crosstalk between autophagy and ferroptosis. Ischemic stroke is a complex brain disease regulated by several cell death pathways, including autophagy and ferroptosis. However, the potential links between autophagy and ferroptosis in ischemic stroke have not yet been explored. In this review, we briefly overview the mechanisms of ferroptosis and autophagy, as well as their possible connections in ischemic stroke. The elucidation of crosstalk between different cell death pathways may provide insight into new future ischemic stroke therapies.

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Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Wang

et al. 2023

Advanced Science

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Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases, and strokes. Accumulating evidence supports ferroptosis as a critical factor of neurodegenerative diseases and strokes, and pharmacological inhibition of ferroptosis as a therapeutic target for these diseases. In this review article, the core mechanisms of ferroptosis are overviewed and the roles of ferroptosis in neurodegenerative diseases and strokes are described. Finally, the emerging findings in treating neurodegenerative diseases and strokes through pharmacological inhibition of ferroptosis are described. This review demonstrates that pharmacological inhibition of ferroptosis by bioactive small‐molecule compounds (ferroptosis inhibitors) could be effective for treatments of these diseases, and highlights a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes. This review article will shed light on developing novel therapeutic regimens by pharmacological inhibition of ferroptosis to slow down the progression of these diseases in the future.

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Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

Cited by 96 publications

References 24 publications

Cross Talk Between Ferroptosis and Cerebral Ischemia

Cross Talk Between Ferroptosis and Cerebral Ischemia

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

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