Extract of radish (R. Sativus Linn) promotes anti-atherosclerotic effect using urine metabolomics in ApoE−/− mice

Hepatoprotective Effects of Radish (Raphanus sativus L.) on Acetaminophen-Induced Liver Damage via Inhibiting Oxidative Stress and Apoptosis

“…Radishes are an agricultural product with excellent nutritional value owing to their rich moisture and fiber content, and high content of vitamins A and C. In addition, they have traditionally been known to have various benefits, such as digestion-promoting, stomach-protecting, anti-inflammatory, anticancer, antioxidant, and hemostatic benefits [ 15 ]. These physiological effects can be observed in various functional ingredients such as glucosinolates [ 16 ], isothiocyanates, flavonoids, anthocyanins, alkaloids, saponins, and phenolic acids, which are abundant in radishes [ 17 ].…”

Identification of Novel Biomarkers for Early Diagnosis of Atherosclerosis Using High-Resolution Metabolomics

“…Elevated hypoxanthine levels significantly increased cholesterol levels in serum and the AS plaque area [48]. The presence of plaque in blood vessels can limit blood flow and the amount of oxygen supplied to tissues [3]. This, in turn, affects cellular metabolism and energy production, leading to low ATP (adenosine triphosphate) and high hypoxanthine production [6,49].…”

“…Atherosclerosis (AS) is a multifactorial process with global economic and medical importance, with an increased prevalence to cause mortality and morbidity worldwide, and is the main contributor to cardiovascular diseases including stable angina pectoris, myocardial infarction, and stroke [1]. The initiation of AS results from the accumulation of plaque in the sub-endothelial space of arteries, leading to insufficient blood flow and oxygen delivery to vital organs [2,3] It is also characterized as a chronic, multifactorial, and progressive disease showing notable variations in metabolites during different pathological stages [4]. At the initial stage of AS, metabolic imbalances such as a decrease in glucose and glycine and an increase in low-density lipoprotein (LDL) cholesterol may be observed, but without any clear clinical symptoms [5].…”