Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes

Williams, Jennifer; Choe, Young Min; Noss, Michael J.; Baumgartner, Carl J; Mustad, Vikkie A.

doi:10.1093/ajcn/86.1.124

Cited by 67 publications

(52 citation statements)

References 19 publications

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“…The possible insulinogenic effect of SOE was found to continue for a sustained period of 16 weeks. In this context, a clinical trial which was done by Williams et al, [16] showed that the S.oblonga extract could lower acute glycaemia and insulinaemia in persons with type 2 DM after a high carbohydrate meal. The authors also concluded that this extract may be beneficial in the postprandial glucose control.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and Hypolipidemic Effect of Salacia Oblonga in Streptozotocin Induced Diabetic Rats

Bhat

Raghuveer

D’Souza³

et al. 2012

JCDR

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Objectives: The present study was conducted to evaluate the effect of a standardized hydroalcoholic root extract of Sala¬cia oblonga (SOE) on the Random Blood Glucose (RBG) levels, serum insulin, glycated haemoglobin (HbA1c) and the serum lipid profile in long standing, experimentally induced Diabetes Mellitus (DM) with glibenclamide (Glb) as the standard. Materials and Methods:Streptozotocin (STZ) induced, diabetic, Wistar rats of either sex were treated with two oral doses of SOE, 100 and 50mg/kg body wt /day, for a period of 16 weeks. The RBG was estimated at day-1 and at the end of the 16 weeks by using a glucometer. The fasting serum insulin was determined by an ELISA technique. The plasma HbA1c was evaluated by a Turbidimetric Inhibition Immunoassay (TINIA) and the lipid profile was estimated enzymatically.Results and Analysis: A 45% decrease in the RBG was seen after the treatment with the higher dose of SOE, whereas a 44% decrease was observed with the lower dose as com¬pared to the diabetic control. Serum insulin was significantly increased (P<0.05) in all the treated groups as compared to the diabetic control. Plasma HbA1c was significantly decreased (P<0.05). The serum Triacyl Glycerol (TG) levels were signifi¬cantly decreased (P<0.05) in the treated rats as compared to the diabetic control. A significant increase in HDL-cholesterol (P<0.05) in the diabetic rats as a result of the 100mg/kg SOE treatment was a remarkable finding.Conclusion: SOE improves the glycaemic parameters in diabetic rats after a prolonged treatment. The serum TG levels were normalized on treatment. A higher dose of the extract could not alter the parameters significantly, except for HDL-C.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic and Hypolipidemic Effect of Salacia Oblonga in Streptozotocin Induced Diabetic Rats

Bhat

Raghuveer

D’Souza³

et al. 2012

JCDR

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“…8 A similar product of Salacia species (Salacia oblonga) noted that, in 66 overweight type II diabetic persons given either 240mg or 480mg of a Salacia Oblonga extract (ethanol and water extract) prior to a sugary meal (maltodextrin, sucrose, corn syrup; 110g total), that the extract was able to reduce the peak postprandial glucose reading by 19% and 27% (240mg and 480mg; respectively) and reduced the 3-hour AUC by 14% and 22%; following this reduction in glucose was a reduction in serum insulin, reducing the peak by 9 and 12% and the 3 hour AUC by 14% and 19% in type 2 DM. 15 Yoshino et al, 16 reported an oral pre-administration of extracts of Salacia leaves and stems at doses of 100, 200 and 400mg/kg body weight prevented the elevations of lipid peroxides and injury markers in a dose-dependent manner. Decrease of antioxidant activity in plasma of mice treated with Fe-NTA was also prevented by administration of these extracts.…”

Section: Recent Preclinical and Clinical Studies Have Demonstrated Thatmentioning

confidence: 99%

Salacia Chinensis Extract (SCE) Modulates Carbohydrates and Lipid Metabolism: in vitro and in vivo Models

Ghanam¹,

Srivastava²,

Deshp³

et al. 2016

EMIJ

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Background: Salacia Chinensis (SC) is herbal medicine in Ayurvedic medicine. The extract of Salacia chinensis showed preventive effects on various metabolic health disorders.Objective: The aim of this study was to elucidate the therapeutic efficacy of the extract of Salacia chinensis extract (SCE) and modulation of carbohydrate and lipid metabolism in in vitro and in vivo models. Methods:In vitro studies were conducted to study the effect of Salacia chinensis extract (SCE, OmniLean TM ) on alpha-glucosidase, pancreatic lipase and HMG-CoA reductase. The activity of α-glucosidase was assessed using mammalian α-glucosidase extracted from rat intestinal acetone powder (Sigma) and p-nitrophenyl L-D glucopyranoside (PNPG) as an artificial substrate. Pancreatic lipase activity was assessed using pancreatic porcine lipase and 4-methylumbelliferyl oleate (MU Oleate) as substrate. Lipase activity was measured using a fluorescence kinetic assay. HMG-CoA reductase was the rate-limiting step in cholesterol synthesis. The activity of HMG-CoA reductase was assessed using HMG-CoA reductase assay kit (Sigma CS1090). Nutrigenomics study was conducted to study the effect of SCE on fatty acids, PPAR gamma and C/EBP α. In an in vivo model, fifty-six (56) male C57BL/6 mice were purchased from Charles River Labs, at the age of 5 weeks. The mice were housed individually in mouse cages in a temperature-controlled room with a 12-hour light and dark cycle and free access to regular rodent chow and water. After a week of adaptation, the mice were divided into 3 groups with 8 mice in each group. All mice were fed a high-fat diet (60% energy from fat) to induce obesity. One of the group was administered with low (100mg/kg/d) and high (500mg/kg/d) doses of SCE suspending in 0.5% carboxymethyl cellulose, respectively for 7.5 weeks (52 days). One group was used as the obese control (N=8) and gavage with the vehicle control. Body weights were obtained daily and food intake was recorded thrice every week. Fecal samples were collected during week 6 and 7. Serum lipid analysis, glycerol, free fatty acids, hormonal assays (ghrelin, adiponectin, leptin, insulin, glucose and GLP), fecal crude lipids and histopathology changes were assessed.Results: Salacia chinensis extract (SCE) showed a significant inhibitory effect on α-glucosidase. SCE demonstrated a significant inhibitory effect against pancreatic lipase, compared to orlistat. SCE inhibited HMG-C0A only at higher concentration (1mg/ml). In nutrigenomics model, SCE upregulated C/EBP alpha and down regulated ACC, PPARG and SCD-1. SCE at the dose of 500mg/kg/d significantly slowed body weight gain, reduced food intake, increased adiponectin, decreased fat pads mass and increased fecal fat excretion in animal model. SCE significantly decreased significantly serum glycerol levels (by 69%) and free fatty acids levels (by 77%) compared to control group. Treatment with SCE decreased by 20% leptin levels and by 21% insulin levels and increases by 16% adiponectin but did not affect glucose or GLP-1...

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“…A recent study where a cinnamon extract was administered to healthy volunteers had no effect on PPG (Markey et al, 2011). However, several human studies with the herbal extract of Salacia oblonga have demonstrated significant decreases in postprandial glucose levels in DIET AND BLOOD GLUCOSE REGULATION 575 both healthy and T2DM subjects (Collene et al, 2005;Heacock et al, 2004;Williams et al, 2007). The mechanism of action is considered to be through competitive inhibition of a-glucosidase activity and two bioactive phytochemicals kotalanol and salacinol have been isolated (Matsuda et al, 2005).…”

Section: Impact Of Phytochemicals On Blood Glucose Regulationmentioning

confidence: 99%

Impact of Diet Composition on Blood Glucose Regulation

Russell

Baka

Björck

et al. 2013

Critical Reviews in Food Science and Nutrition

191

121

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Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary components on blood glucose levels. Included are the major macronutrients; carbohydrate, protein and fat, micronutrient vitamins and minerals, nonnutrient phytochemicals and additional foods including low-calorie sweeteners, vinegar, and alcohol. Based on the evidence presented in this review, it is clear that dietary components have significant and clinically relevant effects on blood glucose modulation. An integrated approach that includes reducing excess body weight, increased physical activity along with a dietary regime to regulate blood glucose levels will not only be advantages in T2DM management, but will benefit the health of the population and limit the increasing worldwide incidence of T2DM.

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Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes

Cited by 67 publications

References 19 publications

Antidiabetic and Hypolipidemic Effect of Salacia Oblonga in Streptozotocin Induced Diabetic Rats

Antidiabetic and Hypolipidemic Effect of Salacia Oblonga in Streptozotocin Induced Diabetic Rats

Salacia Chinensis Extract (SCE) Modulates Carbohydrates and Lipid Metabolism: in vitro and in vivo Models

Impact of Diet Composition on Blood Glucose Regulation

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