Extracting effective diffusion parameters from drying experiments

Abstract

Thin polymer coatings produced from water-and organic-solvent-based

A minimal model for solvent evaporation and absorption in thin films

“…In contrast to explicit models that consider detailed physicalchemical processes [50,51,52], the minimal model is analytically tractable. Thus, an asymptotic study of the model was carried out, which yielded novel analytical expressions that can be used to extract parameter values from experimental data.…”

“…By invoking thermodynamic principles [57,62,63,50], it is possible to derive nonlinear relationships between the flux J and the solvent fraction φ.…”

“…Simplifications of these models that neglect the detailed mechanics of the polymer matrix have been proposed in the context of drug delivery [47,48,49]. The extensive detail of existing models [50,51,52] for solvent evaporation and absorption in thin films has enabled a wealth of insight to be gained into these technologically relevant processes. However, the complexity of these models can restrict their practical use, since sophisticated computational methods and a large number of parameters may be required to solve the governing equations and hence make theoretical predictions.…”

Understanding isothermal semicrystalline polymer drying: Mathematical models and experimental characterization

“…[5][6][7][8][9][10][11] Drying models for amorphous polymer slabs as well as coatings in reacting as well as nonreacting systems have been developed. [12][13][14][15][16][17][18][19][20][21][22][23][24] All the above ap-proaches considered both isothermal and nonisothermal drying of amorphous polymers. However, very little is understood regarding the solvent removal from semicrystalline polymers.…”

Nonlinear Model-Based Control of Thin-Film Drying for Continuous Pharmaceutical Manufacturing

“…The film temperature and solvent concentration are measured at 18 equidistant points along the moving liner in the drying compartment. 48−50 Quantitative predictions of thin-film drying require accurate characterization of the falling-rate period of drying, which is a nonisothermal process often dominated by diffusion-limited behavior 51 and involves film shrinkage and the nonlinear dependence of the polymer− solvent mutual diffusion coefficient on temperature and concentration. Figure 2 presents a schematic of the thin-film drying process.…”