In conclusion, we put forward a four-channel fiber ring-down pressure sensor with temperature compensation based on neural networks. Using time-division multiplexing principle, this sensor consists of four fiber ring-down loops whose structure is characterized by a combination of series and parallel connection. Its feasibility has been proved by experiment, which shows its good performance both for time-division multiplexing detection and for removing disturbance of temperature. In addition, considering multimode fiber dispersion in optical fiber, we have also discussed the maximum number of multiplexed channels available in this multiplexing system. The idea of the four-channel fiber ring-down pressure sensor with neural networks makes ring-down detection technology more practical and efficient and can be used in other fields, such as physiological processes involving several biological parameters.