Extraction and Determination of Two Antidepressant Drugs in Human Plasma by Dispersive Liquid–Liquid Microextraction‒HPLC

Vaghar-Lahijani, Gholamreza; Saber-Tehrani, Mohammad; Azar, Parviz Aberoomand; Soleimani, Mojtaba

doi:10.1134/s1061934818020144

Cited by 15 publications

(5 citation statements)

References 26 publications

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“…On the other hand, as the alkyl chain length increases, solubility in aqueous solutions decreases, and the analyte availability increases. This seems to be the reason for good results for [C 8 MIM][PF 6 ] IL[72][73][74][75]79,83,84] (Figure…”

mentioning

confidence: 87%

“…An important factor presented in the literature is the combination of ILs with organic solvents. Most often they are the dispenser solvent, but they can also be the solvent in back extraction [15,70,[74][75][76][77][78][79][83][84][85][86]89]. It is known that ILs are highly viscous compounds.…”

Section: Biological Samplesmentioning

confidence: 99%

“…In some extractions, organic solvents are completely eliminated using instead sonication, controlled temperature, or intensive mixing. Their application helps to disperse ILs and gives as good results as organic solvents [15,74,[76][77][78][79][83][84][85][86]. Gong et al [75], during the determination of ulipristal acetate, completely eliminated the organic solvent as a dispersing agent.…”

Section: Biological Samplesmentioning

confidence: 99%

“…As mentioned before, in addition to several constant elements, there are also several variables, such as analytes and matrices. Studies usually extract drugs commonly used to treat humans and animals, including antibiotics [81,82,[86][87][88], antidepressants [78,79,83], benzodiazepines [15,76,77] and NSAIDs [70,85]. The matrices are most often human urine, plasma and serum (Table 2).…”

Section: Biological Samplesmentioning

confidence: 99%

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The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body’s equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

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confidence: 87%

Section: Biological Samplesmentioning

confidence: 99%

Section: Biological Samplesmentioning

confidence: 99%

Section: Biological Samplesmentioning

confidence: 99%

See 2 more Smart Citations

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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“…The literature has documented numerous analytical techniques for the determination of ADs. The most commonly used are high performance liquid chromatography (HPLC) coupled to UV-Vis or a mass spectrometric detector (MS) [6][7][8][9][10][11][12][13]. Gas chromatography (GC) coupled to MS [14][15][16][17] or tandem MS [18], and the capillary electrophoretic technique (CE) have also been reported [19].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Utility of Fabric Phase Sorptive Extraction and HPLC-UV-Vis/DAD to Determine Antidepressant Drugs in Environmental Aqueous Samples

et al. 2020

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Depression is considered to be one of the most prevalent mental disorders in humans. Antidepressant drugs are released in large concentrations and cause adverse effects on the environment and/or human health. Fabric Phase Sorptive Extraction (FPSE), a contemporary solid sorbent-handling technique, is a quick, sensitive, and simple analytical process. This paper describes a micro-extraction FPSE procedure coupled with High-Performance Liquid-Chromatography–Photodiode Array Detection (FPSE-HPLC–DAD) for the simultaneous extraction and analysis of five antidepressants, namely citalopram, clozapine, mirtazapine, bupropion and sertraline. Three fabric media (Whatman Cellulose filter, Whatman Microfiber Glass filter and Polylactic acid disks) and two different sol–gel sorbents (polyethylene glycol (PEG 300), alongside poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG-PPG-PEG 5.800)) were tested. The best FPSE device was observed to be the microfiber glass filter coated with PEG 300 sol–gel sorbent. In addition, the parameters that affect the efficiency of the process (FPSE media and sorbents, sample pH, extraction time, elution time, etc.) were optimized. The proposed methodology displays a linear range with absolute recovery values higher than 60%, RSD% of less than 13% and LOQs in the range between 1.9–10.7 μg·L−1. Finally, the method was applied in hospital and urban effluents and lake water samples, but none of the analytes were detected.

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Hollow fiber coated Fe3O4@Maleamic acid-functionalized graphene oxide as a sorbent for stir bar sorptive extraction of ibuprofen, aspirin, and venlafaxine in human urine samples before determining by gas chromatography–mass spectrometry

et al. 2021

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Extraction and Determination of Two Antidepressant Drugs in Human Plasma by Dispersive Liquid–Liquid Microextraction‒HPLC

Cited by 15 publications

References 26 publications

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

Investigating the Utility of Fabric Phase Sorptive Extraction and HPLC-UV-Vis/DAD to Determine Antidepressant Drugs in Environmental Aqueous Samples

Hollow fiber coated Fe3O4@Maleamic acid-functionalized graphene oxide as a sorbent for stir bar sorptive extraction of ibuprofen, aspirin, and venlafaxine in human urine samples before determining by gas chromatography–mass spectrometry

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