Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats

Jagadish, P C; Latha, K; Mudgal, Jayesh; Nampurath, Gopalan Kutty

doi:10.1016/j.jep.2016.10.010

Cited by 40 publications

(27 citation statements)

References 17 publications

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“…In addition, 5-hydroxy-3,7,3′,4′-tetramethoxyflavone ( 96 ) inhibited PGE 2 release with an IC 50 value of 16.3 μM, with negative activity on Tumor Necrosis Factor alpha (TNF- α ) with IC 50 >100 μM [44]. Petroleum ether extract from K. galanga was active against acute inflammation at 300 mg/kg in rats and inhibited the inflammation and MPO levels at 100 mg kg −1 in the chronic model [45].…”

Section: Biological Activitymentioning

confidence: 99%

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

et al. 2019

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Background: Plants belonging to the genus Kaempferia (family: Zingiberaceae) are distributed in Asia, especially in the southeast region, and Thailand. They have been widely used in traditional medicines to cure metabolic disorders, inflammation, urinary tract infections, fevers, coughs, hypertension, erectile dysfunction, abdominal and gastrointestinal ailments, asthma, wounds, rheumatism, epilepsy, and skin diseases. Objective: Herein, we reported a comprehensive review, including the traditional applications, biological and pharmacological advances, and phytochemical constituents of Kaempheria species from 1972 up to early 2019. Materials and methods: All the information and reported studies concerning Kaempheria plants were summarized from library and digital databases (e.g., Google Scholar, Sci-finder, PubMed, Springer, Elsevier, MDPI, Web of Science, etc.). The correlation between the Kaempheria species was evaluated via principal component analysis (PCA) and agglomerative hierarchical clustering (AHC), based on the main chemical classes of compounds. Results: Approximately 141 chemical constituents have been isolated and reported from Kaempferia species, such as isopimarane, abietane, labdane and clerodane diterpenoids, flavonoids, phenolic acids, phenyl-heptanoids, curcuminoids, tetrahydropyrano-phenolic, and steroids. A probable biosynthesis pathway for the isopimaradiene skeleton is illustrated. In addition, 15 main documented components of volatile oils of Kaempheria were summarized. Biological activities including anticancer, anti-inflammatory, antimicrobial, anticholinesterase, antioxidant, anti-obesity-induced dermatopathy, wound healing, neuroprotective, anti-allergenic, and anti-nociceptive were demonstrated. Conclusions: Up to date, significant advances in phytochemical and pharmacological studies of different Kaempheria species have been witnessed. So, the traditional uses of these plants have been clarified via modern in vitro and in vivo biological studies. In addition, these traditional uses and reported biological results could be correlated via the chemical characterization of these plants. All these data will support the biologists in the elucidation of the biological mechanisms of these plants.

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Section: Biological Activitymentioning

confidence: 99%

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

et al. 2019

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“…While, Indian Ayurvedic formulations such as Karpuardyarka, Karchuradichurna, Sutasekara rasa, Karchuratailam, and Nalpamaraditailam, used for the treatment of muscular swelling and rheumatism also consisting of KG rhizomes [1]. In addition to its traditional use in south-east countries, a number of experimental studies have also demonstrated that K. galanga have antioxidant [7], cytotoxic [8], anti-inflammatory [9], sedative, [10], vasorelaxant [11], anti-angiogenic, [12], antinociceptive [1], and wound healing [13] activities. Pharmacological activities of KGR are mainly due to the presence of secondary metabolites of different nature [11,14,15].…”

Section: Introductionmentioning

confidence: 99%

Aromatic ginger (Kaempferia galanga L.) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits

et al. 2019

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“…Moreover, traditional use for P. dioica suggests a beneficial effect for gastrointestinal and metabolic disorders as it is used for dyspepsia and diabetes, to relieve indigestion and as purgative in different folk medicines (Zhang and Lokeshwar, 2012). K. galanga extracts have been shown to act anti-inflammatory (Jagadish et al, 2016) and its constituent ethyl cinnamate is reported to have vasorelaxant activity (Othman et al, 2006). Activation of TGR5 could play a role in several of these reported activities.…”

Section: Discussionmentioning

confidence: 99%

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

et al. 2017

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Worldwide, metabolic diseases such as obesity and type 2 diabetes have reached epidemic proportions. A major regulator of metabolic processes that gained interest in recent years is the bile acid receptor TGR5 (Takeda G protein-coupled receptor 5). This G protein-coupled membrane receptor can be found predominantly in the intestine, where it is mainly responsible for the secretion of the incretins glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). The aim of this study was (i) to identify plant extracts with TGR5-activating potential, (ii) to narrow down their activity to the responsible constituents, and (iii) to assess whether the intestinal microbiota produces transformed metabolites with a different activity profile. Chenodeoxycholic acid (CDCA) served as positive control for both, the applied cell-based luciferase reporter gene assay for TGR5 activity and the biotransformation assay using mouse fecal slurry. The suitability of the workflow was demonstrated by the biotransformation of CDCA to lithocholic acid resulting in a distinct increase in TGR5 activity. Based on a traditional Tibetan formula, 19 plant extracts were selected and investigated for TGR5 activation. Extracts from the commonly used spices Syzygium aromaticum (SaroE, clove), Pimenta dioica (PdioE, allspice), and Kaempferia galanga (KgalE, aromatic ginger) significantly increased TGR5 activity. After biotransformation, only KgalE showed significant differences in its metabolite profile, which, however, did not alter its TGR5 activity compared to non-transformed KgalE. UHPLC-HRMS (high-resolution mass spectrometry) analysis revealed triterpene acids (TTAs) as the main constituents of the extracts SaroE and PdioE. Identification and quantification of TTAs in these two extracts as well as comparison of their TGR5 activity with reconstituted TTA mixtures allowed the attribution of the TGR5 activity to TTAs. EC50s were determined for the main TTAs, i.e., oleanolic acid (2.2 ± 1.6 μM), ursolic acid (1.1 ± 0.2 μM), as well as for the hitherto unknown TGR5 activators corosolic acid (0.5 ± 1.0 μM) and maslinic acid (3.7 ± 0.7 μM). In conclusion, extracts of clove, allspice, and aromatic ginger activate TGR5, which might play a pivotal role in their therapeutic use for the treatment of metabolic diseases. Moreover, the TGR5 activation of SaroE and PdioE could be pinpointed solely to TTAs.

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Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats

Cited by 40 publications

References 17 publications

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review

Aromatic ginger (Kaempferia galanga L.) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

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