Extraction, isolation and NMR data of the tetraether lipid calditoglycerocaldarchaeol (GDNT) from Sulfolobus metallicus harvested from a bioleaching reactor

Bode, Moira L.; Buddoo, Subash R.; Minnaar, Sanet H.; Plessis, Chris A. du

doi:10.1016/j.chemphyslip.2008.02.005

Cited by 25 publications

(27 citation statements)

References 21 publications

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“…Procedures for the isolation of BTL from the archaea have been described in detail in the literature (Bode et al, 2008;Chang and Lo, 1991;Chang, 1994;Kates, 1986;Lai et al, 2008;Lo et al, 1989;Lo and Chang, 1990). The first step is to use the modified Bligh and Dyer technique (e.g., Lai et al, 2008) or Soxhlet extraction (e.g., Lo and Chang, 1990) to obtain the total lipid extract.…”

Section: Isolation Of Btl From the Archaeamentioning

confidence: 99%

Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties

Chong

2010

Chemistry and Physics of Lipids

128

117

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Section: Isolation Of Btl From the Archaeamentioning

confidence: 99%

Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties

Chong

2010

Chemistry and Physics of Lipids

128

117

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“…Tetraether lipids from biomass of Thermoplasma acidophilum were extracted in the presence of chloroform:methanol (2:1 v/v) as described above [12]. After extraction, organic solution was removed by drying of the sample under vacuum at 50 °C to prevent the oxida-www.pss-c.com…”

Section: Preparation Of Concanavalin a -Modified Tel Liposomesmentioning

confidence: 99%

“…liposomes TEL was extracted from biomass of Thermoplasma acidophilum in the presence of chloroform:methanol (2:1 v/v) [12][13][14]. TEL was mixed with DPPC in the concentration of 1 mg/ml (70:30 molar ratio) and dried under vacuum at 50 °C in round bottomed flask in order to obtain a thin lipid film.…”

Section: Preparation Of Non-activated Tetraether Lipidmentioning

confidence: 99%

Selective interactions of concanavalin A‐modified tetraether lipid liposomes

Özcetin

Dayyoub

Hobler

et al. 2011

Phys. Status Solidi C

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For the development of site specific liposomes, high stability and long circulation properties are very promising for the improvement of drug targeting and drug delivery system as well as improvement of bioavailability of efficient bioactive drugs. Tetraether lipids (TELs) are very stabile lipids, extracted from Thermoplasma acidophilum. Because of its high chemical stability and its biocompatibility, Tetraether lipid liposomes prepared with TELs are excellent candidates for liposomal drug delivery. In this study a model protein, Concanavalin A (ConA) was chosen for a simulation of a specific adsorbtion onto mannan surface. Concanavalin A (ConA) is a lectin, extracted from Canavalia ensiformis, which interacts with sugar domains localized on inflammatory active tissues or tumors. In this study, stable TEL liposomes were prepared and characterized. Furthermore to develop side specific liposomes, tetraether lipids were activated and, ConA was covalently bond onto the surface of the prepared liposomes. Interaction of ConA conjugated liposomes with mannan‐modified surfaces was investigated by Biomolecular Interaction Analysis (BIA) via Reflectometric Interference Spectroscopy (RIfS). This provides real time observation of interactions between carbohydrate structure and TEL liposomes. Specific interaction was also visualised by AFM imaging subsequent to the RIfS measurements. According to the results, with ConA conjugated liposomes, high specific adsorption efficiency was observed. Consequently, this specific adsorption assay between ConA and mannan surface can be considered as a model for the further studies utilized with specific biomarkers for a selective active agent transfer to tumors and inflammatory active tissues. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…To the best of our knowledge, only two five-membered cyclitols derivatives have been isolated from natural sources ( Figure 2): Caryose 1 [52][53][54], isolated from the lipopolysaccharide fraction of Pseudomonas caryophylli (a plant pathogenic bacteria), and calditol 2, isolated from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius, a thermoacidophilic archaeon belonging to Sulfolobus species. These species were found to grow between 75 and 80 ∘ C, with pH optimum in the range of 2-3 [55][56][57][58]. The original proposed structure for calditol, an open-chain branched nonitol 3, was soon questioned by various research groups.…”

Section: Natural Carbafuranosesmentioning

confidence: 99%

Biosynthesis and Biological Activity of Carbasugars

Roscales

Plumet

2016

International Journal of Carbohydrate Chemistry

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The first synthesis of carbasugars, compounds in which the ring oxygen of a monosaccharide had been replaced by a methylene moiety, was described in 1966 by Professor G. E. McCasland's group. Seven years later, the first true natural carbasugar (5a-carba-R-D-galactopyranose) was isolated from a fermentation broth of Streptomyces sp. MA-4145. In the following decades, the chemistry and biology of carbasugars have been extensively studied. Most of these compounds show interesting biological properties, especially enzymatic inhibitory activities, and, in consequence, an important number of analogues have also been prepared in the search for improved biological activities. The aim of this review is to give coverage on the progress made in two important aspects of these compounds: the elucidation of their biosynthesis and the consideration of their biological properties, including the extensively studied carbapyranoses as well as the much less studied carbafuranoses.

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Extraction, isolation and NMR data of the tetraether lipid calditoglycerocaldarchaeol (GDNT) from Sulfolobus metallicus harvested from a bioleaching reactor

Cited by 25 publications

References 21 publications

Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties

Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties

Selective interactions of concanavalin A‐modified tetraether lipid liposomes

Biosynthesis and Biological Activity of Carbasugars

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