Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels

Lima, Gabriel Goetten de; Souza, Ronaldo O. de; Bozzi, Aline D.; Poplawska, Malgorzata A.; Devine, Declan M.; Nugent, Michael

doi:10.1016/j.xphs.2015.12.027

Cited by 43 publications

(39 citation statements)

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“…Polyvinyl alcohol (PVA) is a synthetic biocompatible polymer that is able to form physical or chemical crosslinking based on different methods such as UV‐irradiation or freeze‐thawing . Freeze thawing PVA hydrogels are a good alternative for producing biomedical composites or drug delivery devices because the process does not contain any solvent or other components that can increase the overall toxicity. Freeze‐thawed hydrogels are formed upon freezing the solubilized polymer, and physical crosslinking occurs via hydrogen boding based on the ice crystals growth .…”

Section: Introductionmentioning

confidence: 99%

Composite cryogels for dual drug delivery and enhanced mechanical properties

et al. 2017

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In this study, we present a simple and effective process that integrates hydrogels with drugs + ceramics via physical crosslinks resulting in improved mechanical properties. These cryogels have the potential for controlled drug release and stimulus responsive behavior. The hydrogels were produced from polyvinyl alcohol (PVA) and polyacrylic acid by varying the molecular weight of the polymers, via freeze‐thawing technique. The cryogels were combined with two ceramics: (1) a combination of beta‐tricalcium phosphate, wollastonite, magnesium silicate and (2) titanium dioxide nanopowder. Theophylline, a model drug, was incorporated into the structure to analyze the drug release behavior. A layered structure was produced by adding both hydrogels + ceramics into a mold where a PVA dried film acted as a barrier and reinforcing structure. The results showed that the barrier integrated between both hydrogels by a physically crosslinking mechanism. This adhesion was demonstrated using Fourier‐transform infrared spectroscopy and scanning electron microscopy. Swelling of this composite showed the profile of drug release from both hydrogels + ceramics while simultaneously releasing the drug independently without diffusing via the opposite layer. Finally, mechanical properties were improved with the addition of the ceramics, which demonstrates the potential approach in terms of modification of weak hydrogel systems. POLYM. COMPOS., 39:E210–E220, 2018. © 2017 Society of Plastics Engineers

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Section: Introductionmentioning

confidence: 99%

Composite cryogels for dual drug delivery and enhanced mechanical properties

et al. 2017

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“…This result indicates that these drugs interfere with the availability of hydrophilic sites in the samples . Therefore, there are increased intermolecular interactions when drugs are loaded that interfere with water ingress between the alginate chains . Furthermore, the drugs could be located in hydrogel pores, occupying the free space that water occupies during swelling…”

Section: Resultsmentioning

confidence: 99%

“…65 Therefore, there are increased intermolecular interactions when drugs are loaded that interfere with water ingress between the alginate chains. 68 Furthermore, the drugs could be located in hydrogel pores, occupying the free space that water occupies during swelling. 69 The swelling characteristics of neomycin samples are shown in Figure 5B.…”

Section: Swelling Degree Gel Fraction and Weight Lossmentioning

confidence: 99%

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

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et al. 2019

Polymers for Advanced Techs

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Alginate hydrogels have many attractive characteristics for potential use as wound dressing materials. However, they are not considered to possess any intrinsic activity against microbial infection, often present in neuropathic wounds. To overcome this, the effect of incorporating neomycin or propolis in alginate hydrogels was investigated, both by direct blending alone and also by further addition of loaded alginate microparticles prepared by the extrusion dripping method. The morphological, microstructural, thermal, mechanical, and swelling properties of each film were evaluated, as well as particle size distribution and antimicrobial penetration analysis. Microparticle size was considered suitable for drug delivery applications and incorporation in hydrogel films. The presence of neomycin and propolis, in both blended and microparticle form, interfered with film properties leading to hydrogels with different characteristics. All samples showed swelling degrees up to 100% and mechanical and thermal properties suitable for application as wound dressings. In addition, all samples acted as barriers to microbial penetration.

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“…Propolis ekstraksiyonunda en çok tercih edilen etanolün [7][8][9][10][11][12][13][14][15][16] dışında su [17,18], metanol [19][20][21], metilen klorür [19], diklorometan [20], hegzan [22], etil asetat [23], aseton [18], zeytinyağı [11], β-siklodekstrin [11], dimetilsülfoksit [18,24], propilen glikol, etil asetat ve kloroform [25] propolisin ekstraksiyonu için tercih edilen diğer çözücü bileşenlerdir.…”

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Effects of Propolis Extraction with Different Solvents on Total Phenolic Content, Antioxidant Capacity and Antimicrobial Activity

Bakkaloğlu

Arıcı

2019

Akademik Gıda

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Z. Bakkaloğlu) 0 212 383 45 72 0 212 383 45 71 ÖZ Arıcılıktan elde edilen doğal bir biyolojik ürün olan propolis antibakteriyel, antifungal, antiviral, antitümoral ve anestezik aktivite dahil olmak üzere birçok yönüyle dikkat çekmektedir. Ayrıca çok düşük toksisiteye sahip olması nedeniyle sağlık, gıda, kozmetik gibi sanayi dallarında hammadde olarak kullanılmaktadır. Sektörlerin kullanım amacına bağlı olarak ekstrakte edilmesi gereken propolis için farklı çözücüler tercih edilmektedir. Kullanılan çözücülerin farklı olması propolisin fonksiyonel özellikleri üzerine etki etmektedir. Propolisin farklı çözücülerle ekstraksiyonu toplam fenolik bileşen içeriği, antioksidan kapasitesi ve antimikrobiyal özelliklerinde farklılıklara neden olmaktadır. Bu derlemede, propolis ekstraktlarında kullanılan farklı çözücüler ve bu çözücülerin propolisin toplam fenolik bileşen, antioksidan kapasitesi ve antimikrobiyal üzerine etkileri tartışılmıştır. ABSTRACTPropolis, a natural biological product obtained from beekeeping, attracts attention in many aspects including antibacterial, antifungal, antiviral, antitumoral and anesthetic activity. It is also used as a raw material in health, food and cosmetic industries because of its low toxicity. Different solvents are preferred for the extraction of propolis depending on the intended use of the sectors. The different solvents may have an effect on the functional properties of propolis. Extraction of propolis with different solvents may result in differences in the total phenolic content, antioxidant capacity and antimicrobial properties. In this review, different solvents used in propolis extracts and their effects on the total phenolic content, antioxidant capacity and antimicrobial properties of propolis are discussed. GİRİŞFonksiyonel birer gıda ürünü olan bal ve diğer arı ürünleri son yıllar da arıcılığa verilen önemle beraber öne çıkmaktadır. Arı ürünleri; bal, polen ve arı ekmeği gibi doğrudan insan gıdası olarak tüketilen arı sütü, propolis gibi işlenerek insan gıdası olarak tüketilenler ve arı zehri, bal mumu gibi doğrudan insan gıdası olarak tüketilmeyen olmak üzere üç gruba ayrılabilir [1].Arıcılık ürünlerinin Çin kitabelerinde ve Mısır'daki yazılı kaynaklarda milattan önce ve sonraki dönemlerde hastalıkların tedavi edilmesinde kullanıldığı belirtilmektedir [2]. Günümüzde ise arıcılık ürünlerinin (bal, polen, propolis, arı ekmeği, arı zehri, bal mumu)

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Extraction Method Plays Critical Role in Antibacterial Activity of Propolis-Loaded Hydrogels

Cited by 43 publications

References 56 publications

Composite cryogels for dual drug delivery and enhanced mechanical properties

Composite cryogels for dual drug delivery and enhanced mechanical properties

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Effects of Propolis Extraction with Different Solvents on Total Phenolic Content, Antioxidant Capacity and Antimicrobial Activity

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