Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography–diode array detection

Namera, Akira; Nakamoto, Akihiro; Nishida, Munehiro; Saito, Takeshi; Kishiyama, Izumi; Miyazaki, Shota; Yahata, Midori; Yashiki, Mikio; Nagao, Masataka

doi:10.1016/j.chroma.2008.08.091

Cited by 69 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, the monolithic spin column extraction method has been reported as being a quick extraction technique for use prior to chromatographic analysis. [1][2][3] Target compounds in a matrix are extracted using the monolithic spin column with only centrifugation. The eluting solvent is injected directly into the analytical instrument without the need for drying, because the final volume of the eluting solvent is small.…”

Section: Introductionmentioning

confidence: 99%

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

et al. 2011

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

et al. 2011

Self Cite

View full text Add to dashboard Cite

“…RSDs of intraand interday ranging from 2.0 to 10.0% and from 5.3 to 12.1% are obtained, respectively. Comparative study of our developed method with other reported sample preparation procedures [27][28][29][30] was performed and the results are summarized in Table 6. It can be seen that the developed method is very sensitive, and it is surely much less complicated and time consuming.…”

Section: Methodological Validationmentioning

confidence: 99%

Magnetic solid‐phase extraction using magnetic hypercrosslinked polymer for rapid determination of illegal drugs in urine

Gao¹,

Lin²,

Luo³

et al. 2011

J of Separation Science

View full text Add to dashboard Cite

A novel magnetic material Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB) was prepared via the hypercrosslinking of its precursor which was produced via precipitation polymerization of methacrylic acid (MAA), vinylbenzyl chloride (VBC), and divinylbenzene (DVB) in the presence of Fe(3)O(4)/SiO(2) submicrospheres with the surface containing abundant reactive double bonds. The resultant sorbent was characterized by scan electron microscopy, N(2) adsorption, and Fourier transform infrared spectroscopy. It was found that this material had remarkable features such as large surface area (500 m(2)/g) and pore volume (0.32 cm(3)/g), as well as desirable chemical composition (including hydrophobic and ion-exchange moieties). Taking advantages of the Fe(3)O(4)/SiO(2)/P(MAA-co-VBC-co-DVB), a magnetic SPE (MSPE) coupled with capillary electrophoresis (CE) method was developed for the determination of illegal drugs in urine samples. The extraction time could be clearly shortened up to 3 min. The recoveries of these drug compounds were in the range of 84.0-123% with relative standard deviations ranging between 1.7 and 10.5%; the limit of detection was in the range of 4.0-6.0 μg/L. The proposed method is simple, effective, and low-cost, and provides an accurate and sensitive detection platform for abused drug analysis.

show abstract

“…Recently, the application of monolith for SPE, especially in the field of bioanalysis has attracted considerable attention [2,7,8]. Although much of the effort had been devoted to exploiting the applicability of polymer-based monolith in SPE, few studies have explored silica-based monolith after surface modification [7,9,10]. This could be attributed to the stability of the polymer-based monolith over a wider pH range when compared to the silica-based monolith.…”

mentioning

confidence: 99%

Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC‐MS/MS)

Nema

Chan

2011

J of Separation Science

View full text Add to dashboard Cite

The high surface area monolith with reactive hydroxyl group on its surface enables it to function as a miniature solid-phase extraction (SPE) cartridge in size of 1 cm in diameter and 0.5 cm in length. The prepared silica monolith was characterized by Brunauer-Emmett-Teller method, scanning electron microscopy, X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy. Ketamine was selected as model analyte to validate the extraction efficiency of the prepared cartridge. The extracted ketamine from urine sample was quantitated by liquid chromatography tandem mass spectrometry (LC-MS/MS) using positive electrospray ionization. The limit of detection and quantification for ketamine was found to be 0.5 and 1.6 ng/mL, respectively. The analysis exhibited linearity in the range of 10-500 ng/mL with coefficient of correlation >0.99. The recovery was found to be in the range of 89-107% with relative standard deviation (RSD) less than 10%. The prepared cartridge was found robust in extracting ketamine efficiently and repeatedly without any significant deterioration in its performance. Moreover, the batch-to-batch variations in the performance of the prepared cartridges in terms of % ion suppression of the extracts and recoveries of samples were small, suggesting the consistency in the properties of the monolith.

show abstract

Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography–diode array detection

Cited by 69 publications

References 17 publications

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

Magnetic solid‐phase extraction using magnetic hypercrosslinked polymer for rapid determination of illegal drugs in urine

Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC‐MS/MS)

Contact Info

Product

Resources

About