R EUSING wastewater as an additional resource of water in Egypt always be facing by high load of contaminants, especially potentially toxic elements (PTEs). Sorption of PTEs is one of the technologies used for treatment wastewater. Cellulose derived materials, like microcrystalline cellulose, can be used for removal of PTEs. In this study, microcrystalline cellulose prepared from rice straw with an eco-friendly method and tested for Pb, Cd, and Cu removal from artificial contaminated water. Factors affecting metal ions removal were also investigated. Obtained results showed that the removal efficiency of the PTEs was 94, 72, and 89% for Pb, Cd, and Cu, respectively at 10 mg L -1 of microcrystalline cellulose. Removal of Cd and Cu decreased with increasing of initial concentration up to 200 mg L -1 , however, for Pb the removal efficiency was near 90% till initial concentration 150 mg L -1 . In summary, the prepared microcrystalline cellulose were shown as promising adsorbents can assist PTEs from contaminated wastewater.