Extraction of Nanohydroxyapatite from Waste Bovine Bone Using Alkaline Digestion Method

Adenan, Nur Hamiza; Zainol, Ismail; Rahim, N A; Jaafar, Che Nor Aiza

doi:10.1088/1742-6596/1082/1/012005

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…In a study focused on the synthesis of HA from marine shell waste, Ca/P ratios of between 2.1 and 1.75 were obtained, and the difference from the theoretical ratio of 1.67 was attributed to traces of carbonate still present in the samples [42]. In other cases, however, HA has been obtained with a lesser amount of other compounds, such as when is it obtained from waste bovine bone using an alkaline digestion method, which provided a Ca/P molar ratio of 1.75, which is similar to previous reports using fresh bovine bones [43]. Regarding a potential compatibility of the material obtained with human tissue, it should be highlighted that no heavy metals were found in the EDX analyses performed, which is promising for biological applications.…”

Section: Resultssupporting

confidence: 85%

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

Suffo-Pino,

Cauqui-López,

Pérez-Muñoz

et al. 2023

JFB

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This study focuses on developing hydroxyapatite synthesized from a CaCO3-rich byproduct of sugar beet processing called Carbocal® using a hydrothermal reactor. The purpose of this biomaterial is to enhance the osteoinductivity of implantable surfaces and serve as a bone filler, providing a sustainable and economically more affordable alternative. This research involved compositional analysis and micro- and macrostructural physicochemical characterization, complemented with bioactivity and live/dead assays. The biphasic nature of the Carbocal®-derived sample was significant within the context of the bioactivity concept previously proposed in the literature. The bioactivity of the biomaterial was demonstrated through a viability test, where the cell growth was nearly equivalent to that of the positive control. For comparison purposes, the same tests were conducted with two additional samples: hydroxyapatite obtained from CaCO3 and commercial hydroxyapatite. The resulting product of this process is biocompatible and possesses properties similar to natural hydroxyapatite. Consequently, this biomaterial shows potential as a scaffold in tissue engineering and as an adhesive filler to promote bone regeneration within the context of the circular bioeconomy in the geographical area proposed.

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Section: Resultssupporting

confidence: 85%

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

Suffo-Pino,

Cauqui-López,

Pérez-Muñoz

et al. 2023

JFB

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“…-[100] Treat with 0.1 M HCl, 5 M NaOH HA 1.75 cut/20 -30 nm needle Calcine @ 1200 °C Cortical bone[101,102] Subcritical water: 129 ºC carbonated HA -I: 25, II: 45μm/I: 10 -83, II: 7.2 -83.1 nm hexagonal Calcine @ I:600 -1100 or II: 600 -1000 °C, 5 °C min −1 Femur[103] Treat with 0.7M NaCl, acetone, 1M HCl -ground/--…”

mentioning

confidence: 99%

A review on bovine hydroxyapatite; extraction and characterization

Moradi

Pakizeh

Ghassemi

2021

Biomed. Phys. Eng. Express

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High rate of bone grafting surgeries emphasizes the need for optimal bone substitutes. Biomaterials mimicking the interconnected porous structure of the original bone with osteoconductive and osteoinductive capabilities have long been considered. Hydroxyapatite (HA), as the main inorganic part of natural bone, has exhibited excellent regenerative properties in bone tissue engineering. This manuscript reviews the HA extraction methods from bovine bone, as one of the principal biosources. Essential points in the extraction process have also been highlighted. Characterization of the produced HA through gold standard methods such as XRD, FTIR, electron microscopies (SEM and TEM), mechanical/thermodynamic tests, and bioactivity analysis has been explained in detail. Finally, future perspectives for development of HA constructs are mentioned.

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“…Whereas the HA synthesized from Salmon bones by hydrothermal process at 120 °C for 8 h exhibited high sphericity with nano-sized particles in a range of 30 to 60 nm. 55 Furthermore, Adenan et al 56 synthesized nano-sized (20–30 nm) HA with high sphericity morphology from waste bovine bone using alkaline hydrothermal method ( Fig. 5d ).…”

Section: Materials Recovery From Bone Wastementioning

confidence: 99%

Value-added materials recovered from waste bone biomass: technologies and applications

et al. 2022

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Extraction of Nanohydroxyapatite from Waste Bovine Bone Using Alkaline Digestion Method

Cited by 6 publications

References 9 publications

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

A review on bovine hydroxyapatite; extraction and characterization

Value-added materials recovered from waste bone biomass: technologies and applications

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