Extraction of Nicotine from Tobacco Leaves and Development of Fast Dissolving Nicotine Extract Film

Kheawfu, Kantaporn; Kaewpinta, Adchareeya; Chanmahasathien, Wisinee; Rachtanapun, Pornchai; Jantrawut, Pensak

doi:10.3390/membranes11060403

Cited by 24 publications

(20 citation statements)

References 37 publications

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“…The accumulated concentration of sample in the dissolution medium (φ) is less than one-third of its saturation solubility [ 24 ]. On the other hand, NCT is soluble in water at temperatures below 60.8 °C (1 × 10 6 g/L); consequently, the calculated φ value is 0.0001 and was less than one-third of its saturation solubility [ 25 , 26 ]. As a result, this in vitro release experiment was classified as a sink condition.…”

Section: Resultsmentioning

confidence: 99%

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Formulation and Characterization of Nicotine Microemulsion-Loaded Fast-Dissolving Films for Smoking Cessation

2022

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The present study aimed to develop a nicotine microemulsion (NCT-ME) and incorporate it into a fast-dissolving film. The NCT-ME was prepared by mixing the specified proportions of nicotine (NCT), surfactant, co-solvent, and water. The NCT-ME was measured by its average droplet size, size distribution, zeta potential, and morphology. NCT-ME fast-dissolving films were prepared by the solvent casting technique. The films were characterized by morphology, weight, thickness, disintegration time, and mechanical strength properties and the determined NCT loading efficiency and in vitro drug release. The results showed that almost all NCT-MEs presented droplet sizes of less than 100 nm with a spherical form, narrow size distribution, and zeta potentials of −10.6 to −73.7 mV. There was no difference in weight and thickness between all NCT-ME films, but significant changes in the disintegration times were noticed in NCT40-Smix[PEG-40H(2:1)]10 film. The mechanical properties of films varied with changes in type of surfactant. About 80% of the drug release was observed to be between 3 and 30 min. The drug release kinetics were fitted with the Higuchi matrix model. The NCT40-Smix[P-80(1:1)]10 film showed the highest dissolution rate. It was concluded that the developed ME-loaded fast-dissolving film can increase drug release to a greater extent than the films without ME.

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Section: Resultsmentioning

confidence: 99%

“…The drug release kinetics and mechanism were described using a variety of kinetic models. To receive the best-fit model, the in vitro dissolution data were correlated to the zero-order model, first-order model, Higuchi model, and Korsmeyer–Peppas empirical power law [ 25 , 35 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

Formulation and Characterization of Nicotine Microemulsion-Loaded Fast-Dissolving Films for Smoking Cessation

2022

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“…Corn plants aged 21 days were given spraying on each sample of corn plants, whereas for the control sample, only water was given without any mixture. In contrast, for samples of chemical pesticides, biopesticides A, B, and biopesticides C was given a ratio of 1000 ml of water with 30 ml of chemical pesticides, biopesticide A, biopesticide B, and biopesticide C [21]. Samples of corn plants that have been sprayed are left in a place where there are pests for seven days and are monitored every day.…”

Section: Resultsmentioning

confidence: 99%

Tobacco extract-based biopesticide from cigarette butt waste for corn plants (Zea mays L.)

Nurhidayah

Abdullah²,

Sholehah

et al. 2022

J. Pijar.MIPA

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Cigarette butt waste can be used for biopesticides for environmentally friendly agricultural activities. Biopesticides cigarette can be produced by conducting a maceration extraction test using polar, non-polar, and semi-polar compounds and conducting a Mass Spectrometer Chromatography (GC-MS) test. This study aims to determine the effectiveness of bio-pesticide based on tobacco extract from cigarette butt waste for maize (Zea mays L.)". The highest yield value was the ethanol sample of 1.208%, compared to the N-hexane sample of 0.25% and the DCM sample of 0.6%. For the comparison of solvents used were 500 ml of ethanol, 250 ml of N-hexane, and 250 ml for DCM as well. After conducting the GC-MS test, the compounds obtained are alkaloid compounds, phenolic compounds, sesquiterpenoid compounds, and terpenoid compounds, each of which has benefits as a pest control or deterrent to plants. For the effectiveness test results on Corn (Zea mays L.), there was no intensity of pest attack on the ethanol sample, N-hexane sample, and DCM sample. In contrast, there was a pest attack intensity of 0.3% for the control sample. Therefore, the Biopesticides studied are similar to synthetic pesticides because they can eradicate pests and make growth effective faster.

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“…Drug release kinetics and mechanism were described by different drug release kinetic models. The first 60% of the data of the drug release was fixed with zero-order, first-order, Higuchi and Korsmeyer-Peppas models described in Equations ( 5)-( 8), respectively [19].…”

Section: In Vitro Drug Release Profile and Release Kineticmentioning

confidence: 99%

Composite Nanocellulose Fibers-Based Hydrogels Loading Clindamycin HCl with Ca2+ and Citric Acid as Crosslinking Agents for Pharmaceutical Applications

et al. 2021

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Biocomposite hydrogels based on nanocellulose fibers (CNFs), low methoxy pectin (LMP), and sodium alginate (SA) were fabricated via the chemical crosslinking technique. The selected CNFs-based hydrogels were loaded with clindamycin hydrochloride (CM), an effective antibiotic as a model drug. The properties of the selected CNFs-based hydrogels loaded CM were characterized. The results showed that CNFs-based hydrogels composed of CNFs/LMP/SA at 1:1:1 and 2:0.5:0.5 mass ratios exhibited high drug content, suitable gel content, and high maximum swelling degree. In vitro assessment of cell viability revealed that the CM-incorporated composite CNFs-based hydrogels using calcium ion and citric acid as crosslinking agents exhibited high cytocompatibility with human keratinocytes cells. In vitro drug release experiment showed the prolonged release of CM and the hydrogel which has a greater CNFs portion (C2P0.5A0.5/Ca + Ci/CM) demonstrated lower drug release than the hydrogel having a lesser CNFs portion (C1P1A1/Ca + Ci/CM). The proportion of hydrophilic materials which were low methoxy pectin and sodium alginate in the matrix system influences drug release. In conclusion, biocomposite CNFs-based hydrogels composed of CNFs/LMP/SA at 1:1:1 and 2:0.5:0.5 mass ratios, loading CM with calcium ion and citric acid as crosslinking agents were successfully developed for the first time, suggesting their potential for pharmaceutical applications, such as a drug delivery system for healing infected wounds.

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Extraction of Nicotine from Tobacco Leaves and Development of Fast Dissolving Nicotine Extract Film

Cited by 24 publications

References 37 publications

Formulation and Characterization of Nicotine Microemulsion-Loaded Fast-Dissolving Films for Smoking Cessation

Formulation and Characterization of Nicotine Microemulsion-Loaded Fast-Dissolving Films for Smoking Cessation

Tobacco extract-based biopesticide from cigarette butt waste for corn plants (Zea mays L.)

Composite Nanocellulose Fibers-Based Hydrogels Loading Clindamycin HCl with Ca2+ and Citric Acid as Crosslinking Agents for Pharmaceutical Applications

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