Extraction of phytochemicals using hydrotropic solvents

Nagarajan, Jayesree; W, Heng; Galanakis, Charis M.; Ramanan, Ramakrishnan Nagasundara; Raghunandan, Mavinakere Eshwaraiah; Jian, Sun; Ismail, Amin; Tey, Beng Ti; Prasad, K. Nagendra

doi:10.1080/01496395.2016.1143842

Cited by 42 publications

(15 citation statements)

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“…Therefore, the development of environmentally friendly solvents with low toxicity and cost, as alternatives to the conventional organic solvents, became mandatory [ 25 ]. The extraction of phytochemicals with hydrotropic solvents is becoming the new trend [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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: Deep eutectic solvents (DESs) have got huge interest as new green and sustainable solvents for the extraction of bioactive compounds from plants in recent decades. In the present study, we aimed to investigate the effectiveness of hydrophilic DES for the extraction of anthocyanin and polyphenol antioxidants from Roselle. A natural hydrophilic DES constituted of sodium acetate (hydrogen bond acceptor) and formic acid (hydrogen bond donor) designed to evaluate the total phenolic compound (TPC), total flavonoid (TFC), total anthocyanin (TACN), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) values of Roselle. Distilled water, 70% ethanol, and 80% methanol used as conventional solvents for comparison. The results indicated that the DES prepared in molarity ratio (SAFAm) was the most efficient. Subsequently, this prominent DES selected for the optimization and the optimum extraction conditions were 1:3.6 molarity ratio, 0% additional water, and 10 mL solvent. TPC, TFC, TACN, FRAP, and DPPH radical scavenging at the optimum point were 233.26 mg GAE/g, 10.14 mg ECE/g, 10.62 mg D3S/g, 493.45 mmol ISE/g, and 343.41 mmol TE/g, respectively. The stability tests showed that anthocyanins were more stable in SAFAm. These findings revealed that SAFAm is an effective green solvent for the extraction of polyphenols from various plants.

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Section: Introductionmentioning

confidence: 99%

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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“…They typically consist of a benzene-substituted molecule (hydrophobic part) and an ionic group (hydrophilic head). They are similar to surfactants; however, the hydrophobic part is too small to form a micelle through spontaneous self-aggregation [325]. At a particular concentration, which is known as the minimum hydrotrope concentration (MHC), hydrotropes can aggregate.…”

Section: Surfactants and Hydrotropesmentioning

confidence: 99%

Green Approaches to Sample Preparation Based on Extraction Techniques

Aly

Górecki

2020

Molecules

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Preparing a sample for analysis is a crucial step of many analytical procedures. The goal of sample preparation is to provide a representative, homogenous sample that is free of interferences and compatible with the intended analytical method. Green approaches to sample preparation require that the consumption of hazardous organic solvents and energy be minimized or even eliminated in the analytical process. While no sample preparation is clearly the most environmentally friendly approach, complete elimination of this step is not always practical. In such cases, the extraction techniques which use low amounts of solvents or no solvents are considered ideal alternatives. This paper presents an overview of green extraction procedures and sample preparation methodologies, briefly introduces their theoretical principles, and describes the recent developments in food, pharmaceutical, environmental and bioanalytical chemistry applications.

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“…In hydrotropic solubilization technique an electrostatic force of the donor-acceptor molecule plays a vital role; hence, they are also termed as a structurebreaker and a structure-maker 35,36 . Solutes which are capable both of hydrogen donation and acceptance help to enhance solubility.…”

Section: Structure-breaker and Structure-makermentioning

confidence: 99%

Untitled

2019

IJPSR

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Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development and clinical testing but also an obstacle at the very beginning while screening new compounds for pharmacological activity. Nowadays oral route is considered as the preferred route of drug administration than other routes due to its convenience in terms of ease of administration and economy. The first requirement of drug which is supposed to be given by oral route is good aqueous solubility, as the poor solubility leads to low absorption, inadequate and variable bioavailability and also gastrointestinal mucosal toxicity. To prevent these crisis, several solubility enhancement techniques have been employed to enhance the solubility of poorly soluble drugs and hydrotropic solubilization is one of them. Besides, the advantage of certain properties like high selectivity, non-inflammability, environmentally friendly, easy availability and cost-effectiveness of hydrotropes makes this technique superior to other solubilization techniques. In the present review, an attempt has been made to discuss the hydrotropic solubilization technique and highlight the applications with this approach.

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Extraction of phytochemicals using hydrotropic solvents

Cited by 42 publications

References 50 publications

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

Green Approaches to Sample Preparation Based on Extraction Techniques

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