Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts

Lim, Mi Jeong; Gu, Yul Ri; Hong, Joo-Heon

doi:10.11002/kjfp.2019.26.5.566

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…According to a previous report [32], AE of S. baicalensis roots showed the highest TPC, TFC, DPPH, ABTS, FRAP, and reducing power. This supports our study's results, showing that the aqueous ethanol (AE) had the highest TPC, TFC, and antioxidant activities.…”

Section: Pearson Correlation Analysis Between the Phenolic And Flavon...mentioning

confidence: 63%

Effects of Different Solvents on the Extraction of Phenolic and Flavonoid Compounds, and Antioxidant Activities, in Scutellaria baicalensis Hairy Roots

Lim,

Kim,

Kwon

et al. 2024

Horticulturae

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The hairy roots (HRs) of Scutellaria baicalensis are widely used and consumed worldwide as a medicine, especially in Asian countries, due to their biological and pharmacological activities. The HRs of this plant are rich in secondary metabolites. However, the optimal method and solvents for the extraction of secondary metabolites from S. baicalensis HRs have not been well studied. Therefore, in this study, S. baicalensis HRs were extracted with different solvents, including water (WE), 99.9% pure methanol (PM), 70% aqueous methanol (AM), 99.9% pure ethanol (PE), and 70% aqueous ethanol (AE). The phenolic and flavonoid compounds and various antioxidant activities of each extract were measured. The AE extract (16.85 ± 0.15%) had a higher yield, which led to the highest accumulation of total phenolic content (TPC) and total flavonoid content (TFC), and antioxidant activity. The TPC and TFC were highest in AE (66.03 ± 0.44 mg GAE/g and 40.11 ± 1.31 mg QE/g, respectively), whereas WE, PM, and PE showed lower values in all assays. In addition, the highest antioxidant activities, such as DPPH, ABTS, and SOD-like scavenging activities and reducing power, were achieved in the AE extract compared to the other solvent extracts. Based on these results, the AE extract showed the highest phenolic and flavonoid accumulation and antioxidant activities, highlighting its potential use in the manufacture of useful materials from S. baicalensis HRs and its novel applications.

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Section: Pearson Correlation Analysis Between the Phenolic And Flavon...mentioning

confidence: 63%

Effects of Different Solvents on the Extraction of Phenolic and Flavonoid Compounds, and Antioxidant Activities, in Scutellaria baicalensis Hairy Roots

Lim,

Kim,

Kwon

et al. 2024

Horticulturae

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Physiological activities of Pyrus pyrifolia Nakai, malt, Ziziphus jujuba Mill., Leonurus japonicus Houtt., Scutellaria baicalensis, and their mixtures

Lee,

Kim,

Chung

2023

Korean J. Food Preserv.

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This study investigated the anti-inflammatory, trypsin activity, and antioxidant effects of 11 kinds of plant extracts to discover materials for developing optimal mixtures that improve inflammation and help digestion. Ziziphus jujuba Mill. (ZJ), Leonurus japonicus Houtt. (LJ), Scutellaria baicalensis (SB), Platycodon grandiflorum, and Aster scaber extracts had excellent anti-inflammatory effects by reducing excessive nitric oxide (NO) and tumor necrosis factor-α content in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The malt (MA), Pyrus pyrifolia Nakai (PP), Raphanus sativus L., Platycodon grandiflorum extracts among the 11 kinds of plant extracts had high trypsin activity. The antioxidant activity of the plant extracts was examined by the DPPH radical scavenging activity, and the SB, PE, JU, and MA extracts had high antioxidant activity. Therefore, PP, MA, ZJ, LJ, and SB were selected to develop optimal mixtures that improve inflammation and help digestion. The extract of plant mixture containing PP, MA, ZJ, LJ, and SB in the ratio 1:1:2:1:2 (w/w) significantly inhibited NO production than the extract of PP, MA, ZJ, LJ, and SB, respectively, in LPS-stimulated RAW 264.7 macrophages. The DPPH radical scavenging activity of the mixture extract was significantly higher than the extract of PP, MA, ZJ, and LJ, respectively.

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Antioxidant, whitening and anti-obesity effects of red-fleshed pitaya (Hylocereus polyrhizus) extract

Lee,

Lee

et al. 2024

Food Eng. Prog.

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This study investigated the antioxidant, whitening, and anti-obesity properties of red-fleshed pitaya extracts. We aimed to increase the financial value of red-fleshed pitaya and demonstrate its potential as a functional food material in the future. Flesh and peel extracts were obtained using 70% ethanol and water extraction conditions. Total polyphenol content and antioxidant activity (ABTS and DPPH radical scavenging activity) for each extract were measured, and the 70% ethanol peel extract had the highest total polyphenol content and antioxidant activity. Mushroom tyrosinase inhibitory activity was used to measure the whitening effect, with the water flesh extract being the most effective. To investigate the anti-obesity effect, a 3T3-L1 preadipocyte differentiation experiment was performed at a non-cytotoxic concentration using 70% ethanol and water flesh extracts. In comparison to the control, the water flesh extract showed a substantial decrease in lipid accumulation in a dose-dependent manner. The antioxidant activity of the 70% ethanol pitaya peel extracts and the whitening and anti-obesity effects of the water flesh extracts are expected to make pitaya a highly valuable functional food ingredient.

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Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts

Abstract: Extraction solvent-dependent antioxidant activities and cancer cell growth inhibitory effects of Scutellaria baicalensis extracts

Cited by 6 publications

References 30 publications

Effects of Different Solvents on the Extraction of Phenolic and Flavonoid Compounds, and Antioxidant Activities, in Scutellaria baicalensis Hairy Roots

Effects of Different Solvents on the Extraction of Phenolic and Flavonoid Compounds, and Antioxidant Activities, in Scutellaria baicalensis Hairy Roots

Physiological activities of Pyrus pyrifolia Nakai, malt, Ziziphus jujuba Mill., Leonurus japonicus Houtt., Scutellaria baicalensis, and their mixtures

Antioxidant, whitening and anti-obesity effects of red-fleshed pitaya (Hylocereus polyrhizus) extract

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