Extractive separation of amino acid enantiomers with co-extractants of tartaric acid derivative and Aliquat-336

Separation of Biosynthetic Products by Pertraction

“…For this reason, the amino acids solubility in conventional organic solvents is lower, their physical extraction being practically impossible. The liquid-liquid extraction of amino acids becomes possible only by adding extractants into the organic phase, namely derivatives of phosphoric acid (Kelly et al, 1998;Liu et al, 1999;Cacaval et al, 2001;Juong & Wang, 2002;, high molecular weight amines (Rehm & Reed, 1993;Schugerl, 1994;Tan et al, 2007) or some types of crown-ethers (Deblay et al, 1990). The pertraction could be also used for amino acids separation, the proper carrier being chosen from the above listed extractants (organophosphoric acid, high molecular weight amines or crown-ethers).…”

Enantioselective Extraction of Racemic Ofloxacin by Di(2-Ethylhexyl)phosphoric Acid and Tartaric Acid Derivatives as Mixed Complex Chiral Selectors

“…As a potential large scale production technique, solvent extraction has attracted a lot of researchers to make great efforts 5,6 . As is well known, the type of chiral selectors [7][8][9][10][11][12][13][14] and their enantioselectivety play the most important role in the separation efficiency for enantioselective extraction. In relation to the conclusion reported by the previous work 7 , there formed a new complex chiral extractant when mixed O,O'-dibenzoyl-(2R,3R)-tartaric acid (L-(-)-DBTA) and di(2-ethylhexyl)phosphoric acid (D2EHPA), and then both the distribution ratio and enantioselectivity are greatly improved by the formation of the complex instead of L-(-)-DBTA individually.…”

Biphasic recognition chiral extraction: A novel method for separation of mandelic acid enantiomers

“…Many researchers have attempted the separation of optically active compounds. [11][12][13][14][15][16][17][18] Such chiral separation technologies like crystallization, chromatography, kinetic resolution, etc. accelerate researches about chiral compounds, but there still exist some defects for most racemic compounds.…”

“…[11][12][13][14][15][16][17] Separation factor (a) is the most important parameter for chiral extraction. For example, for a 99% pure product (R/S 5 100), about 190 NTU (number of transfer units) are required for an enantioselectiviety of 1.05, a number decreasing to $30, when a increases to a value of 1.20.…”