Extracts of Common Buckwheat Bran Prevent Sucrose Digestion

Hosaka, Toshio; Nii, Yoshitaka; Tomotake, Hiroyuki; Ito, Teruaki; Tamanaha, Aya; Yamasaka, Yukiko; Sasaga, Sayaka; Edazawa, Kazuhiro; Tsutsumi, Rie; Shuto, Emi; Okahisa, Naoki; Iwata, S.; Sakai, Tohru

doi:10.3177/jnsv.57.441

Cited by 21 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice pretreated with the extract showed dose-dependent reduction of blood glucose, within 60 min of sucrose ingestion. The results indicate the antidiabetic property of the bran extract (Hosaka et al, 2011). The addition of bran to brown rice for doenjang (Korean fermented food) preparation was demonstrated to elicit strong anti-obesity and hypolipidaemic effects (Park, Rico, Lee, & Kang, 2012).…”

Section: Food Substitutions and Applicationsmentioning

confidence: 96%

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

Patel

2015

Journal of Functional Foods

View full text Add to dashboard Cite

Section: Food Substitutions and Applicationsmentioning

confidence: 96%

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

Patel

2015

Journal of Functional Foods

View full text Add to dashboard Cite

“…Oxidative stress is a notorious factor in the development of degenerative and age-related diseases such as diabetes (Lee et al, 2007;Hosaka et al, 2011;Yu et al, 2015), cancer (Lee et al, 2013;Zhu, 2016), immunity (Yu et al, 2016), liver injury (Zhang et al, 2014;Pang et al, 2015), cardiovascular (Andriantsitohaina et al, 2012) and neurodegenerative diseases (Choi et al, 2015). Oxidative stress-induced perturbations in the antioxidant defence systems of the body lead to DNA damage and cellular dysfunction, which is further linked to diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive research has reported the potential health benefits of buckwheat, especially its use in Chinese traditional medicine against various cancers (Zhou et al, 2012). Consumption of buckwheat and buckwheat-enriched diets is associated with a myriad of biological activities, such as antidiabetic (Lee et al, 2007;Hosaka et al, 2011), anti-hypercholesterolemic (Choi et al, 2007), anti-oxidative, anti-hypertensive (Merendino et al, 2014), anti-cancer, and anti-inflammatory properties (Lee et al, 2013;Zhu, 2016). Researchers have speculated that these properties could be linked to the potential antioxidant activity of compounds in such diets.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antidiabetic properties of tartary buckwheat rice flavonoids after in vitro digestion

Bao

Wang²,

et al. 2016

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Oxidative stress and diabetes have a tendency to alter protein, lipid, and DNA moieties. One of the strategic methods used to reduce diabetes-associated oxidative stress is to inhibit the carbohydrate-digesting enzymes, thereby decreasing gastrointestinal glucose production. Plant-derived natural antioxidant molecules are considered a therapeutic tool in the treatment of oxidative stress and diabetes. The objective of this study was to identify tartary buckwheat rice flavonoids and evaluate the effect of in vitro digestion on their antioxidant and antidiabetic properties. High performance liquid chromatography (HPLC) analysis indicated the presence of rutin as a major component and quercitrin as a minor component of both digested and non-digested flavonoids. Both extracts showed a significant antioxidant capacity, but digested flavonoids showed reduced activity compared to non-digested. There were some decreases of the antioxidant activities (2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazy (DPPH) radical, and ferric reducing antioxidant power (FRAP)) of digested tartary buckwheat rice flavonoids compared with non-digested. Flavonoids from both groups significantly inhibited reactive oxygen species (ROS) production and α-glucosidase activity. Both digested and non-digested flavonoids markedly increased glucose consumption and glycogen content in HepG2 cells. Tartary buckwheat rice flavonoids showed appreciable antioxidant and antidiabetic properties, even after digestion. Tartary buckwheat rice appears to be a promising functional food with potent antioxidant and antidiabetic properties.

show abstract

“…To determine the effect of BBE on KK-A y mice, we decided to use 1 mg BBE/20 g mice weights treatment once a day, which dose is proved recently by us to lower postprandial glucose (22). Body weight in the BBE treatment group (30.37 !…”

Section: Treatment Of Bbe Lowered Serum Level Of Tg and Fatty Liver Imentioning

confidence: 99%

Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A<sup>y </sup>mice.

et al. 2014

Self Cite

View full text Add to dashboard Cite

Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-A(y) mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.

show abstract

Extracts of Common Buckwheat Bran Prevent Sucrose Digestion

Cited by 21 publications

References 30 publications

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

Antioxidant and antidiabetic properties of tartary buckwheat rice flavonoids after in vitro digestion

Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A<sup>y </sup>mice.

Contact Info

Product

Resources

About