1987
DOI: 10.1159/000249187
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Extracutaneous Spreading with Fatal Outcome of Mycosis fungoides in a Patient Treated with Ciclosporin A: A Word of Caution

Abstract: A patient with mycosis fungoides in the tumor stage was treated with ciclosporin A orally in daily doses of 5 mg/kg body weight for 5 weeks. Three weeks after cessation of treatment the patient died with dissemination of the cutaneous lymphoma to the lungs, myocardium, liver, pancreas, kidneys, adrenals, and stomach. Treatment with ciclosporin A may have contributed to the death of this patient.

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Cited by 27 publications
(9 citation statements)
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“…We have recently described 2 patients with mycosis fungoides who deteriorated following CS therapy [19], and similar ex periences have been published by other in vestigators [20][21][22]. A recent report on skin lesions in 67 CS-treated renal transplant pa tients describes 1 patient who developed multiple skin tumors.…”
Section: Discussionsupporting
confidence: 58%
“…We have recently described 2 patients with mycosis fungoides who deteriorated following CS therapy [19], and similar ex periences have been published by other in vestigators [20][21][22]. A recent report on skin lesions in 67 CS-treated renal transplant pa tients describes 1 patient who developed multiple skin tumors.…”
Section: Discussionsupporting
confidence: 58%
“…Cyclosporine has also been used to prevent transcription in activated T cells by targeting calcineurin, thus reducing specific T‐cell clones and its production of cytokines 51 . However, its use in CTCL has resulted in the emergence of aggressive disease 52,53 . Considering that systemic corticosteroids tend to inhibit T H 1 more than T H 2 immune responses, 54,55 we wonder if treatment may have actually unmasked the erythrodermic MF in our patient, similar to what has been reported with cyclosporine 56 .…”
Section: Commentsupporting
confidence: 70%
“…Nonetheless, systemic absorption is a consideration of potential increased risk of neoplasia in patients treated with TCI. Furthermore, several cases of cutaneous T‐cell lymphoma have also been reported to progress or transform with use of oral calcineurin inhibitors 90–100 …”
Section: Resultsmentioning
confidence: 99%