Extradural motor cortex stimulation for advanced Parkinson disease

Canavero, Sergio; Paolotti, Riccardo; Bonicalzi, Vincenzo; Castellano, Giancarlo; Greco-Crasto, Stefania; Rizzo, Laura; Davini, Ottavio; Zenga, Francesco; Ragazzi, Paola

doi:10.3171/jns.2002.97.5.1208

Cited by 85 publications

(51 citation statements)

References 16 publications

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“…However, antidromic cortical activation also provides a common link between these stimulation sites, which are all in proximity with major cortical output pathways. The clinical benefit of epidural cortical stimulation in the MPTP primate model (Drouot et al 2004) and in some human PD patients (Canavero et al 2002) support the hypothesis that direct control of cortical activity is an effective mechanism in alleviating PD symptoms. However, other human PD patient pools derived no benefits from epidural stimulation (Cilia et al 2007), suggesting that this method produces less than robust effects.…”

Section: Clinical Relevance Of Antidromic Cortical Stimulationmentioning

confidence: 71%

Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation

Arbuthnott²,

Jutras³

et al. 2007

Journal of Neurophysiology

258

248

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nant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. J Neurophysiol 98: 3525-3537, 2007. First published October 10, 2007 doi:10.1152/jn.00808.2007. Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease (PD) for many patients. The most effective stimulation consists of high-frequency biphasic stimulation pulses around 130 Hz delivered between two active sites of an implanted depth electrode to the subthalamic nucleus (STN-DBS). Multiple studies have shown that a key effect of STN-DBS that correlates well with clinical outcome is the reduction of synchronous and oscillatory activity in cortical and basal ganglia networks. We hypothesized that antidromic cortical activation may provide an underlying mechanism responsible for this effect, because stimulation is usually performed in proximity to cortical efferent pathways. We show with intracellular cortical recordings in rats that STN-DBS did in fact lead to antidromic spiking of deep layer cortical neurons. Furthermore, antidromic spikes triggered a dampened oscillation of local field potentials in cortex with a resonant frequency around 120 Hz. The amplitude of antidromic activation was significantly correlated with an observed suppression of slow wave and beta band activity during STN-DBS. These findings were seen in ketamine-xylazine or isoflurane anesthesia in both normal and 6-hydroxydopamine (6-OHDA)-lesioned rats. Thus antidromic resonant activation of cortical microcircuits may make an important contribution toward counteracting the overly synchronous and oscillatory activity characteristic of cortical activity in PD.

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Section: Clinical Relevance Of Antidromic Cortical Stimulationmentioning

confidence: 71%

Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation

Arbuthnott²,

Jutras³

et al. 2007

Journal of Neurophysiology

258

248

View full text Add to dashboard Cite

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“…Their work has been focused more on using MCS to treat movement disorders, in particular PD, rather than pain. 18,33,54,55,57,60,63 Results from these studies were promising in early phases. The Italian Neurosurgical Society study group 60 reported on a group of 16 patients, with a postsurgical time of 3-30 months for the 10 patients ultimately analyzed.…”

Section: Introductionmentioning

confidence: 93%

Motor Cortex Stimulation for Pain and Movement Disorders

Arle

Shils

2008

Neurotherapeutics

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Summary:Since initial reports in the early 1990s, stimulation of the M1 region of the cortex (MCS) has been used to treat chronic refractory pain conditions and a variety of movement disorders. A Medline search of literature between 1991 and 2007 revealed 512 cases using MCS. Although most of these relate to the treatment of pain (422), 84 of them involve movement disorders. More recently, several studies have specifically looked at treating Parkinson's disease (PD) with MCS. We report here several of our own cases using MCS to treat poststroke and non-poststroke pain syndromes and movement disorders (n ϭ 8), PD (n ϭ 4), ET (n ϭ 2), and cortico-basal degeneration (n ϭ 1). We also cover the essential history of this procedure and our current research using computational modeling to understand further the underlying mechanisms of MCS.

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“…A few studies have suggested that this invasive stimulation may be effective in treating the symptoms of some motor disorders (Nguyen et al, 1998) and possibly to be effective for PD as well (Canavero et al, 2002(Canavero et al, , 2003Woolsey et al, 1979). However, other studies found no improvement (Moro et al, 2010).…”

Section: Imaging Tms Effects In Pdmentioning

confidence: 98%

Combining functional imaging with brain stimulation in Parkinson's disease

Obeso

Ray

Antonelli

et al. 2011

International Review of Psychiatry

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Brain stimulation techniques such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) constitute promising clinical and research tools to investigate neural mechanisms underlying neurological and psychiatric diseases. They have enormous potential in modifying brain activity and subsequent function. However, it is still a matter of debate how either of these stimulation approaches operates to produce the clinical outcomes observed in patients. The combination of these techniques with functional neuroimaging is contributing signifi cantly to disentangle the mechanisms through which brain stimulation affects neuronal activity and related networks. In the present review we outline the research done to date on the effects of DBS and TMS on motor, cognition and behaviour in Parkinson ' s disease (PD) with particular emphasis on neuroimaging.

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Extradural motor cortex stimulation for advanced Parkinson disease

Cited by 85 publications

References 16 publications

Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation

Resonant Antidromic Cortical Circuit Activation as a Consequence of High-Frequency Subthalamic Deep-Brain Stimulation

Motor Cortex Stimulation for Pain and Movement Disorders

Combining functional imaging with brain stimulation in Parkinson's disease

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