Extraesophageal acid reflux and recurrent respiratory papilloma in children

Benoit, Margo McKenna; Brodsky, Linda

doi:10.1016/j.ijporl.2004.11.021

Cited by 69 publications

(51 citation statements)

References 20 publications

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“…Some of the factors associated with the more aggressive form of the disease have already been established: infection with HPV 11, early spread of the papillomas to the subglottis, the onset of the disease before the age of 3 years, gastroesophageal reflux and a simultaneous infection with other viruses [2,[11][12][13]. In the case of an aggressive disease, adjuvant therapy is used in most centers [14,15].…”

Section: Introductionmentioning

confidence: 99%

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Boltežar

Matičič

Šereg-Bahar

et al. 2014

Eur Arch Otorhinolaryngol

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In the case of an aggressive course of recurrent respiratory papillomatosis (RRP), adjuvant therapy can be used besides surgery. The aim of the study was to investigate the influence of vaccination with a quadrivalent vaccine against human papilloma viruses (HPV) types 6, 11, 16 and 18 on the course of RRP. Eleven subjects aged 13-46 years with a rapid growth of laryngeal papillomas were included in the study. They were vaccinated with three doses of the quadrivalent prophylactic HPV vaccine (Silgard(®), MSD) and followed up for 12-52 months. The intervals between the successive surgical procedures, the extension of the disease (Derkay score) at each surgery, and the number of surgical procedures per year before vaccination and after its completion were compared. The mean interval between the surgical procedures was 271.2 days before the vaccination and 537.4 days after it (p = 0.034). The mean number of surgeries per year was 2.16 before the vaccination and 0.93 after it (p = 0.022). The Derkay score did not change significantly after vaccination. Complete remission of the disease was observed in one patient, partial response to the vaccination was observed in seven patients and no response was observed in three patients. In conclusion, vaccination with the quadrivalent HPV vaccine can favorably influence the course of RRP in patients with the rapid growth of the papillomas. It significantly prolongs the intervals between the surgical procedures and reduces the number of procedures needed in the majority of patients. The present investigation can serve as a pilot study for further research. For a final conclusion a longer follow-up and studies on more patients are necessary.

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Section: Introductionmentioning

confidence: 99%

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Boltežar

Matičič

Šereg-Bahar

et al. 2014

Eur Arch Otorhinolaryngol

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“…Iatrogenic transmission also deserves attention because HPV can survive on cryoprobe and in the plume generated by carbon dioxide laser. Additionally, extra-esophageal acid reflux disease should be regarded as a high risk factor for RRP (4,5). RRP most commonly occurs in the larynx and lesions of the lower respiratory tract are usually due to the spreading of laryngeal lesions.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Xue

Wang

2010

Intern. Med.

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Recurrent respiratory papillomatosis (RRP) is an infrequent benign neoplasm commonly involving the upper respiratory tract with laryngeal predilection. The diagnosis and treatment of this disease are challenging due to its nonspecific clinical presentations and recurrent nature. We report here a rare juvenile case of RRP arising in the trachea without laryngeal lesions. Our experiences indicate that a high awareness of RRP and proper consideration in the right clinical context are prerequisites for early diagnosis, and a combination of multiple treatment modalities should be considered as a feasible treatment regimen.

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“…Thus, effective diagnosis and treatment of extraesophageal reflux would be important for all RLP patients where disease control is difficult. 11 We decided to use 24-hour double probe (proximal and distal) ambulatory esophageal pH monitoring as this test provides reliable diagnostic confirmation if done adequately and interpreted correctly. 14,15 Although 50% of our patients had physiological distal gastroesophageal reflux, and 90% had a positive proximal reflux, there are still many controversies about what should be considered pathological reflux, particularly in children.…”

Section: Discussionmentioning

confidence: 99%

“…22 Other authors have found a potential relation between the severity of RLP and gastroesophageal reflux. 8,11 Furthermore, recent papers have shown that most of the surgical complications of RLP patients, such as scars, laryngeal membranes, and airway stenosis are late complications and tend to be more significant and frequent in patients with gastroesophageal reflux. 22 Based on our study, we believe that the treatment of reflux may be a further treatment strategy to control this high morbidity disease.…”

Section: Discussionmentioning

confidence: 99%

Refluxo gastroesofágico em pacientes portadores de papilomatose recorrente de laringe

Pignatari

Liriano

Avelino

et al. 2007

Rev. Bras. Otorrinolaringol.

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Evi dence of a relation between gastroesophaeal reflux and pediatric respiratory disorders increases every year. Many respiratory symptoms and clinical conditions such as stridor, chronic cough, and recurrent pneumonia and bronchitis appear to be related to gastroesophageal reflux. Some studies have also suggested that gastroesophageal reflux may be associated with recurrent laryngeal papillomatosis, contributing to its recurrence and severity. Aim: the aim of this study was to verify the frequency and intensity of gastroesophageal reflux in children with recurrent laryngeal papillomatosis. Material and Methods: ten children of both genders, aged between 3 and 12 years, presenting laryngeal papillomatosis, were included in this study. The children underwent 24-hour double-probe pH-metry. Results: fifty percent of the patients had evidence of gastroesophageal reflux at the distal sphincter; 90% presented reflux at the proximal sphincter. Conclusion: the frequency of proximal gastroesophageal reflux is significantly increased in patients with recurrent laryngeal papillomatosis.

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Extraesophageal acid reflux and recurrent respiratory papilloma in children

Cited by 69 publications

References 20 publications

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Human papilloma virus vaccination in patients with an aggressive course of recurrent respiratory papillomatosis

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Refluxo gastroesofágico em pacientes portadores de papilomatose recorrente de laringe

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