Extragastric Diseases and Helicobacter pylori

Abstract

The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease [1]. Here, we shall summarize the results of the most relevant studies published on this topic from

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

“…(iv) A double intoxication then occurs, justifying numerous extradigestive pathologies described in Table 2. (v) This statement is in perfect harmony with recent literature which reports more and more extra-digestive pathologies linked to Helicobacter pylori [23,28,[35][36][37][38][39][40][41].…”

Role of Helicobacter pylori Infection in Body Height of Adult Dyspeptic Patients

“…While the association between H. pylori and GI disease is well established, the role of infection in some extra‐intestinal conditions is less defined . The organism causes a lifelong gastric chronic inflammatory response that may have systemic consequences and/or could act as an immunologic trigger .…”

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

“…In this regard, though controversy still exists, there is growing evidence for an association between Helicobacter pylori and NAFLD, similarly to other manifestations of IR syndrome or metabolic syndrome, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and CVD . As for NAFLD, H pylori infection ( H pylori ‐I) is also highly prevalent worldwide and both are increasing with age.…”