Extragenital adenocarcinoma metastatic to the cervix uteri

Esposito, John M.; Zarou, Donald M.; Zarou, George S.

doi:10.1016/s0002-9378(16)34788-3

Cited by 25 publications

(8 citation statements)

References 11 publications

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“…The rarity of cervical metastatic adenocar cinomas has been explained by several find ings [4,6], These include the occurrence of fibrous tissue in the cervix wall as this organ is unfavorable soil for metastatic growth. Also the small size of the cervix as a target organ, the relatively limited blood flow and the lym phatic drainage of the pelvis away from the cervix have been included as biological expla nations.…”

Section: Introductionmentioning

confidence: 99%

“…Also the small size of the cervix as a target organ, the relatively limited blood flow and the lym phatic drainage of the pelvis away from the cervix have been included as biological expla nations. Medical reasons include failure to screen the cervix routinely in the follow-up of women with adenocarcinoma, and failure to exclude the breast, gastrointestinal tract, and other sites as a primary in cases diagnosed as adenocarcinoma of the cervix [4,6],…”

Section: Introductionmentioning

confidence: 99%

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Adenocarcinoma Metastatic to the Uterine Cervix

Korhonen¹,

Stenbäck²

1984

Gynecol Obstet Invest

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In this study 208 patients with adenocarcinoma of the uterine cervix were examined for the occurrence of tumors metastatic to this location. A total of 45 secondary tumors were found, 31 with a primary endometrial tumor, 6 with an ovarian serous or mucinous adenocarcinoma, 2 tubal tumors, 5 colonic adenocarcinomas, and 1 primary mammary tumor. Clinical and morphological aspects were studied, indicating the need for consideration of metastatic tumors as explanation for suspected neoplastic cervical lesions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adenocarcinoma Metastatic to the Uterine Cervix

Korhonen¹,

Stenbäck²

1984

Gynecol Obstet Invest

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“…The patients' ages ranged from 17 -77 years [9], with an average age of 56.5 years. Metastatic adenocarcinoma of the cervix from colorectal carcinoma has been reported to comprise only 18.5% of all secondary adenocarcinomas of the cervix [5] [8] [13] [16] [18]. The rarity of uterine cervical metastatic adenocarcinomas has been attributed to: 1) the high fibrous tissue content of the cervix providing an unfavorable medium for metastatic growth; 2) the small size and relatively limited blood flow of the cervix as a target organ; 3) the fact that the lymphatic vessels of the pelvis all drain away from the cervix; 4) the failure to exclude possible primary sites in cases diagnosed as adenocarcinoma of the cervix; and 5) the failure to screen the cervix routinely during follow-up in women with adenocarcinomas of extragenital sites [14].…”

Section: Discussionmentioning

confidence: 99%

“…The rarity of uterine cervical metastatic adenocarcinomas has been attributed to: 1) the high fibrous tissue content of the cervix providing an unfavorable medium for metastatic growth; 2) the small size and relatively limited blood flow of the cervix as a target organ; 3) the fact that the lymphatic vessels of the pelvis all drain away from the cervix; 4) the failure to exclude possible primary sites in cases diagnosed as adenocarcinoma of the cervix; and 5) the failure to screen the cervix routinely during follow-up in women with adenocarcinomas of extragenital sites [14]. Failure to examine the cervix during autopsy may also result in an underestimation of the incidence of metastatic adenocarcinoma of the cervix [5] [6] [13] [14] [16].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature

Matsuura¹,

Tamate²,

Suzuki³

et al. 2014

OJOG

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Primary adenocarcinomas of the uterine cervix account for 5% -15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received. KeywordsMetastatic Adenocarcinoma, Cervical Cancer, Colorectal Carcinoma M. Matsuura et al. 618

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“…In those patients with known EU cancers, the presence of malignant cells in cervical cytology may then provide important information about the extent of the neoplasm. Some authors have suggested regular cervical cytology screening in the followup of patients with ovarian and breast carcinoma [26]. The prognostic significance of cervical involvement in EU cancers however is not known, though long-term survival is lower in patients with endometrial adenocarcinoma with cervical involvement than without [27].…”

Section: Discussionmentioning

confidence: 99%