Extragonadal Nongestational Choriocarcinoma Involving the Lung: A Report of Three Cases

Aparicio, Jorge; Oltra, A.; Martínez‐Moragón, Eva; Llorca, Cristina; Gómez-Aldaraví, L.; Pastor, M.

doi:10.1159/000196555

Cited by 19 publications

(20 citation statements)

References 8 publications

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“…It is hypothesized that primary choriocarcinomas derive from neoplastic transformation of misplaced primordial germ cells [15]. The tumors could also represent metastatic lesions from an occult primary gonadal neoplasm undergoing spontaneous regression [11,22]. A neoplastic transformation of pulmonary placental emboli from a previous vesicular mole, term pregnancy, abortion or ectopic pregnancy months or years before also seems possible [3,22].…”

Section: Discussionmentioning

confidence: 99%

“…The tumors could also represent metastatic lesions from an occult primary gonadal neoplasm undergoing spontaneous regression [11,22]. A neoplastic transformation of pulmonary placental emboli from a previous vesicular mole, term pregnancy, abortion or ectopic pregnancy months or years before also seems possible [3,22]. Finally, the tumor could have been generated from a metaplasia or differentiation of somatic neoplastic cells like primary lung cancer [13].…”

Section: Discussionmentioning

confidence: 99%

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Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Serno¹,

Zeppernick²,

Jäkel³

et al. 2012

Gynecol Obstet Invest

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Primary pulmonary choriocarcinoma is a rare disease with only 31 reported cases in the literature so far. Here, we summarize all published cases, including a recent case of our own clinic. Patients usually presented with symptoms like dyspnea, cough, chest pain, weight loss or hemoptysis. In some cases, the nodule in the lung was found in a routine check-up in asymptomatic patients. In the present case, the patient presented to our clinic because of a positive urine pregnancy test despite taking oral contraceptives. Patients in the analyzed cases were either treated with surgery, chemotherapy, radiotherapy or best supportive care. In the present case, a complete resection of the tumor was possible and the patient has not had any signs of recurrence so far. When looking at the published cases and corresponding outcomes, a slight tendency toward a complete resection followed by chemotherapy or close follow-up examinations seems to give the patients the best survival chances. Nevertheless, the overall prognosis of primary pulmonary choriocarinoma is poor and the 5-year survival rate is below 5%.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Serno¹,

Zeppernick²,

Jäkel³

et al. 2012

Gynecol Obstet Invest

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“…Because of the rarity and the clinicopathological similarity of PCC and hCG-producing GCC, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][25][26][27][28][29][30][31][32] the criteria for distinguishing them are unclear. Thus, differential diagnosis has been very difficult.…”

Section: Discussionmentioning

confidence: 99%

“…The disease progression was rapid, and no therapy achieved the predicted efficacy. [4][5][6][7][8][9]25 Although there is no statistically significant difference in survival duration, these patients had relatively good responses to chemotherapy or operation. 1,23 The clinical courses of our patients were consistent with this.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, small-cell carcinoma of the lung often induces paraneoplastic syndromes by producing hormonal factors. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] A diagnosis of PCC should be made carefully. Human chorionic gonadotrophin (hCG) is one of the most common hormones produced by pulmonary carcinomas, 1-3 but clinical findings and problems associated with the hormone are not so frequent.…”

Section: Introductionmentioning

confidence: 99%

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Primary choriocarcinoma and human chorionic gonadotrophin‐producing giant cell carcinoma of the lung: are they independent entities?

et al. 2000

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Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man

Chen

Tatsumi

Numoto

2001

Cancer

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BACKGROUND Human chorionic gonadotropin (hCG)‐producing large or giant cell carcinoma of the lung is not uncommon, but primary pulmonary choriocarcinoma is an extremely rare entity. Even rarer are cases occurring in males; to date the authors have found only 12 reported cases in the English literature. METHODS The clinical record of a 61‐year‐old man who presented with hemoptysis is described. A review of the literature regarding patients with primary pulmonary choriocarcinoma also is reported. RESULTS Computed tomography scan of the chest demonstrated an expanding thickness of the bullous wall within areas of emphysematous change in the lower lobe of the right lung. Moreover, a new, round tumor near the thickness appeared and rapidly expanded evenly into the surrounding lung tissue. Exploratory thoracotomy revealed the previous tumor to be adenocarcinoma with a small foci of choriocarcinoma, and the new tumor to be a hemorrhage with choriocarcinoma. Because of the pleural dissemination, the patient was treated with chemotherapy. At last follow‐up he was alive and well with a gradually increasing serum hCG‐β level in spite of chemotherapy. CONCLUSIONS Primary pulmonary choriocarcinoma occurring in men is an extremely rare entity with a fatal prognosis. Of the 12 cases reported to date in the English literature, 3 cases of choriocarcinoma with the coexistence of another type of pulmonary carcinoma were reported. To the authors' knowledge the clinical relation between these two types of carcinoma are unknown because all cases to date have been detected at the time of autopsy. Only in the current study case could the clinical course of the disease be followed and pathologic confirmation achieved, although the pathogenesis of the two types of carcinoma could not be determined. Cancer 2001;91:123–9. © 2001 American Cancer Society.

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Extragonadal Nongestational Choriocarcinoma Involving the Lung: A Report of Three Cases

Cited by 19 publications

References 8 publications

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Primary choriocarcinoma and human chorionic gonadotrophin‐producing giant cell carcinoma of the lung: are they independent entities?

Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man

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