Extragonadal seminoma

Bokemeyer, Carsten; Jp, Droz; Horwich, A.; Gerl, Arthur; Fosså, Sophie D.; Beyer, J�rg; Pont, J�rg; Schmoll, H.-J.; Kanz, Lothar; Einhorn, Lawrence; Nichols, Craig R.; Hartmann, J�rg T.

doi:10.1002/1097-0142(20010401)91:7<1394::aid-cncr1144>3.0.co;2-y

Cited by 120 publications

(42 citation statements)

References 28 publications

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“…Several studies indicate that histology, location, distant metastases, number of metastatic sites, treatment strategies, pathological evidence of persistent viable cells in the resected specimen, and serum tumor marker levels before or after operation are independent prognostic factors for patients with PMGCTs [17–19]. All 6 patients from our series remain recurrence-free.…”

Section: Discussionmentioning

confidence: 68%

A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy

Tanaka

Okamura

Nagai

et al. 2017

Advances in Urology

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Objectives Primary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment. Methods We examined 6 patients (median age: 25 years, range: 19–27 years) with PMGCTs who underwent multimodal treatment between April 2001 and March 2015. Three patients had seminomas, 2 patients had yolk sac tumors, and 1 patient had choriocarcinoma. The median observation period was 32.5 months (range: 8–84 months). Results Three of the 6 patients received initial operation followed by 3-4 courses of chemotherapy (bleomycin, etoposide, and cisplatin (BEP) or etoposide and cisplatin (EP)). One patient developed multiple lung metastases 17 months after surgery; received salvage chemotherapy with vinblastine, ifosfamide, and cisplatin; and achieved complete remission. The remaining 3 patients received initial BEP and EP chemotherapy. Multiple lung metastases and supraclavicular lymph node metastases were detected in 2 of these patients at the initial diagnosis. The patients underwent resections to remove residual tumor after treatment, and no viable tumor cells were found. Conclusions Reliable diagnosis and immediate multimodal treatments are necessary for patients with PMGCTs. The 6 patients treated in our hospital have never experienced recurrence after the multimodal treatment.

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Section: Discussionmentioning

confidence: 68%

A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy

Tanaka

Okamura

Nagai

et al. 2017

Advances in Urology

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“…With regard to the therapeutic strategies, previous experts summarized their experiences including surgery, chemotherapy, radiotherapy, and high-dose chemotherapy with stem cell support, using small samples (Rodney et al 2010; Kang et al 2008; Bokemeyer et al 2001; Lopes et al 2009; Sakurai et al 2004; Bokemeyer et al 2003; Mann et al 2000). In this study, patients were categorized into four groups: those who received three treatments surgery, chemotherapy, and radiotherapy irrespective of the sequence, those who received two treatments chemotherapy plus surgery or radiotherapy, and those who received single treatment chemotherapy or surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Several prognostic factors were identified to better tailoring treatment. For example, Bokemeyer et al evaluated 635 patients with extragonadal germ cell tumor over 21 years at 11 centers and concluded that liver metastases and two or more metastatic sites influenced survival negatively (Bokemeyer et al 2001). In this study, according to multivariate analysis, disease extension and response rate at initial evaluation were independent prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

“…In literatures, histology (Takeda et al 2003), extended metastases, the number of metastatic sites (Bokemeyer et al 2001), surgical resection of the tumor, pathological evidence of persistent viable tumor in resected remnants (Rivera et al 2010), elevated serum tumor markers after operation (Kesler et al 2008), and so on were considered to be independent prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

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Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum

Liu

Zhang

Liang

et al. 2011

J Cancer Res Clin Oncol

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ObjectiveThe aim of this study was to evaluate the clinical characteristics and survival outcomes of patients with primary mediastinal germ cell tumor (PMGCT) by identifying the prognostic factors and efficacies of different treatment modalities.MethodsFifty-five patients with PMGCT who were treated consecutively at Cancer Center, Sun Yat-sen University, Guangzhou, from 1988 to 2010 were evaluated retrospectively.ResultsFifty-two men and 3 women with a median age of 25 years were identified, of whom 17 (30.9%) had pure seminomatous, 38 (69.1%) had nonseminomatous histology, 27 (49.1%) had tumor located at mediastinum, 20 (36.4%) had lung metastases and/or effusions, and 8 (14.5%) had distant metastases. Three treatments surgery, chemotherapy, and radiotherapy were performed in 11 (20%) patients, two treatments chemotherapy plus surgery or radiotherapy were performed in 25 (45.6%), and single treatment surgery or chemotherapy was performed in 17 (30.9%). The other two patients (3.6%) received no treatment. After a median follow-up time of 31.4 months, the 5-year survival rate was 52%. The median overall survival time was 87.9 months. Patients who received two treatments had the longest survival time of 118.3 months, P = 0.000. Those who had pure seminoma histology, whose tumor confined to the mediastinum and who achieved complete or partial remission at initial evaluation, who had complete resection and radiotherapy were considered to have better prognosis according to univariate analysis. On multivariate analysis, extension and response rate at initial evaluation were independently predictive of survival.ConclusionsPrimary mediastinal germ cell tumor is rare with a dominant frequency in young male patients. Chemotherapy combined with local therapy like surgery or radiotherapy is a reasonable treatment strategy recommended. Extension and initial remission rate are independent prognostic factors.

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“…This tumour most commonly spreads to the regional lymph nodes, lung, liver, and bone. Extragonadal germ cell tumours may reach a large size with no or relatively few symptoms (10). The most common presenting symptoms for patients with endodermal primitive tumours are rapidly enlarging pelvic mass and pain (11).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature

Rudaitis

Mickys²,

Katinaitė

et al. 2016

AML

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Background.Yolk sac tumour diagnosis should be considered for young age patients admitted to the hospital with non-specific complaints of widespread disease. Correct diagnosis and carefully planned treatment is the key to a successful outcome.Methods and materials. We present a rare case of a widespread yolk sack tumour of a uterine broad ligament. Our team directed a special attention towards the patient’s young age, advanced disease, and fertility sparing strategy of treatment.Results and conclusions.Stage IV yolk sac tumours of extragonadal origin are rarely reported in the literature. Hence, diagnosis and treatment often pose a challenge for emergency care unit doctors, gynaecologists, and oncologists. However, it can be a potentially curable disease. Moreover, patients’ fertility can also be preserved. We believe that further analysis of similar cases is necessary to study outcomes and evaluate patients’ responses to a sequence of medical decisions taken for this specific case.

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Extragonadal seminoma

Cited by 120 publications

References 28 publications

A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy

A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy

Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum

Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature

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