Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Byeon, Jangmoo; Cho, Eung‐Ho; Kim, Sang Bum; Choi, Dong Wook

doi:10.14701/kjhbps.2012.16.3.93

Cited by 15 publications

(14 citation statements)

References 16 publications

(20 reference statements)

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“…Byeon et al . reported that the preoperative AFP level was an independent risk factor for EHM ( P = 0.014) after a curative resection of HCC . Biologically, AFP has been reported to promote liver cancer growth and progression .…”

Section: Discussionmentioning

confidence: 99%

“…20 Byeon et al reported that the preoperative AFP level was an independent risk factor for EHM (P = 0.014) after a curative resection of HCC. 7 Biologically, AFP has been reported to promote liver cancer growth and progression. 21 Overexpression of AFP facilitates invasion and distant metastasis of HCC by upregulating the expression of metastasis-related proteins and activating the PI3K/AKT signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…The median survival time after diagnosis of EHM is as low as 4.9 months (range 1–59 months), and the 1‐year survival rate is 24.9% . Similarly, the 5‐year survival rate was lower in the HCC patients with extrahepatic recurrence (21.5%) than those with only intrahepatic recurrence (36.3%; P <0.001) . In addition, the median survival time of HCC patients with EHM was also much shorter than that in those with only intrahepatic recurrence .…”

Section: Introductionmentioning

confidence: 92%

“…6 Similarly, the 5-year survival rate was lower in the HCC patients with extrahepatic recurrence (21.5%) than those with only intrahepatic recurrence (36.3%; P<0.001). 7 In addition, the median survival time of HCC patients with EHM was also much shorter than that in those with only intrahepatic recurrence. 8 Therefore, EHM greatly changes the patients' outcomes and should be crucially considered regarding the selection of initial treatment strategies, particularly for those preparing for curative hepatectomy and liver transplantation.…”

Section: Introductionmentioning

confidence: 94%

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Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data

et al. 2018

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Background and Aim Extrahepatic metastasis (EHM) of hepatocellular carcinoma (HCC) leads to a worse prognosis. We aimed to develop a nomogram based on noninvasive pretreatment clinical data to predict EHM of HCC sooner. Methods Three cohorts containing 1820, 479, and 988 HCC patients were enrolled from three hospitals in different regions in Taiwan and served as the training and validation cohorts. Pretreatment clinical data were analyzed by Cox regression modeling for independent risk factors of EHM. Results Platelet count ≥ 200 × 10 3 /μL, serum alfa‐fetoprotein ≥ 100 ng/dL, tumor size ≥ 3 cm, tumor number > 1, and macrovascular invasion were independent risk factors for EHM and were used to develop a nomogram. This nomogram had concordance indices of 0.733 (95% confidence interval [CI]: 0.688–0.778) and 0.739 (95% CI: 0.692–0.787) for the prediction of EHM during a 5‐year follow‐up duration in the training and validation cohorts, respectively. A nomogram score > 61 implied a high risk of EHM (hazard ratio [HR] = 3.83; 95% CI: 2.77–5.31, P < 0.001). Conclusion We have developed a nomogram that could accurately predict EHM of HCC and be readily available for formulating individualized treatment for all individual HCC patients to improve therapeutic efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 94%

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Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data

et al. 2018

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“…To improve the treatment outcomes and prognosis, predicting distant metastasis of HCC with PVTT is crucial. Variables such as high pretreatment platelet counts, numerous or large tumors, microvascular invasion, incomplete capsulation and high preoperative AFP are significantly associated with distant metastasis in HCC (18)(19)(20)(21); however, prediction models for the metastasis of HCC with PVTT are not currently available, to the best of our knowledge. In the present study, commonly accessed clinical and biochemical parameters were used to screen the risk factors significantly associated with the distant metastasis of primary HCC with PVTT to establish a convenient early warning system for distant metastasis.…”

Section: Discussionmentioning

confidence: 98%

Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus

Zhao²,

Liu

et al. 2020

Oncol Lett

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Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with PVTT. Data from 346 patients (263 and 83 in the modeling and validation cohorts, respectively) who had received primary diagnoses of HBV-HCC and PVTT between January 2012 and June 2015 at Beijing Ditan Hospital (Beijing, China) were retrospectively examined. In the modeling cohort, univariate and multivariate logistic regression analyses were conducted to determine the factors that were significantly associated with distant metastasis. Furthermore, an early risk warning model for distant metastasis was proposed and validated through receiver operating characteristic curve analysis in the validation cohort. The results revealed that neutrophil to lymphocyte ratios of ≥2.31, red blood cell counts of ≥4.07x10 12 cells/l, C-reactive protein levels of ≥7.02 mg/l, aspartate aminotransferase levels of ≥118.5 U/l and tumor thrombus site (at branch) were significantly positively associated with distant metastasis of HBV-HCC with PVTT (P<0.05; odds ratio >1.000). A formula for predicting distant metastasis was obtained with an accuracy of ~70%. The results of the present study may allow for the early prediction of distant metastasis and facilitate the administration of appropriate treatment to improve the outcomes and prognosis of patients with intermediate to advanced HCC.

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Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child–Pugh Class B: a Retrospective Multicenter Study

Tanaka

Noda

Koyama

et al. 2023

Journal of Gastrointestinal Surgery

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Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection

Cited by 15 publications

References 16 publications

Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data

Nomogram predicting extrahepatic metastasis of hepatocellular carcinoma based on commonly available clinical data

Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus

Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child–Pugh Class B: a Retrospective Multicenter Study

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