Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients

Abstract

Mucocutaneous manifestations, arthritis Type 1 and uveitis were significantly more frequent in CD than UC. The complications of the musculoskeletal system were the mostly observed ones, often with symptoms more severe than intestinal ones, confirming the need for close cooperation with rheumatologists.

Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis

“…Remarkably, even in those with longstanding disease, overlap between EAMs appeared to be rather limited in axial SpA. Nevertheless, in a study by Wendling et al, an association between IBD with SpA and psoriasis in a wellestablished cohort of patients with IBP was found (36), while a lower prevalence of acute anterior uveitis in patients with IBD and SpA as compared to patients with classic AS has been reported (35,(37)(38)(39). These seemingly contradictory results might be explained by overlap with peripheral disease, in which the link with EAMs is clearly different.…”

Aberrant brain structural large‐scale connectome in Crohn’s disease

“…The pathophysiology of the disease is not fully understood, but currently accepted to result from a dysregulation of the mucosal immune system in genetically susceptible hosts. In a significant proportion of patients, inflammation also manifests extra‐intestinally, causing inflammatory conditions of the joints, eyes, or skin among other organs . Some neurological issues have also been ascribed to CD and comprise a higher risk for cerebrovascular events and demyelinating disorders that may also be attributed to increased systemic inflammation.…”

“…In a significant proportion of patients, inflammation also manifests extra-intestinally, causing inflammatory conditions of the joints, eyes, or skin among other organs. [1][2][3] Some neurological issues have also been ascribed to CD and comprise a higher risk for cerebrovascular events and demyelinating disorders 4 that may also be attributed to increased systemic inflammation.…”

Respiratory System Involvement in Inflammatory Bowel Diseases

“…Genetic predisposition, environmental factors and abnormal immune processes are believed to be involved [2]. In 15-20% of UC patients and 20-40% of CD patients, so-called extraintestinal manifestations (EIM) of IBD are present [3][4][5][6][7]. Most commonly, involvement of central and peripheral joints, skin, eyes and the hepatobiliary system is seen [3][4][5][6][7].…”

“…In 15-20% of UC patients and 20-40% of CD patients, so-called extraintestinal manifestations (EIM) of IBD are present [3][4][5][6][7]. Most commonly, involvement of central and peripheral joints, skin, eyes and the hepatobiliary system is seen [3][4][5][6][7]. It is most probably related to the presence of circulating antibodies against a colonic epithelial antigen that is shared among these organs [8].…”