Extramammary Pagetʼs Disease

Gregori, Caterina A.; Smith, C I; Breen, James

doi:10.1097/00003081-197821040-00014

Cited by 38 publications

(10 citation statements)

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“…The weight of evidence supports a glandular origin for extramammary Paget's disease. Several series have demonstrated positive immunostaining in Paget cells in contrast to negative intervening keratinocytes and melanocytes 11,12 . We found this technique was particularly useful in identifying extramammary Paget cells alongside adjacent areas of intraepidermal dysplasia.…”

Section: Discussionmentioning

confidence: 75%

Rapid Staining with Carcinoembryonic Antigen Aids Limited Excision of Extramammary Paget's Disease Treated by Mohs Surgery

Harris

Kist

Bloom

et al. 1994

The Journal of Dermatologic Surgery and Oncology

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Extensive extramammary Paget's (EMPD) disease of the perineum in a 68-year-old man was treated by Mohs surgery. To facilitate identification of involved tissue a rapid staining carcinoembryonic antigen was used. This technique proved a useful adjunct to conventional hemotoxylin-eosin (H&E) stains. It was especially useful in highlighting involvement in areas of marked dysplasia/artifact where discrimination is often difficult. It is recommended that such a technique offers considerable benefits over H&E staining when confronted by such tissue morphology.

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Section: Discussionmentioning

confidence: 75%

Rapid Staining with Carcinoembryonic Antigen Aids Limited Excision of Extramammary Paget's Disease Treated by Mohs Surgery

Harris

Kist

Bloom

et al. 1994

The Journal of Dermatologic Surgery and Oncology

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“…Eine Parallel zum Carcinoma in situ der Vulva ergibt sich in der Syntropie des Morbus Paget mit Zweitkarzinomen anderer Organe (Breen et al 1978;Creasman et al 1975;Fenn et al 1971;Fetherson und Friedrich 1972;Koss und Brockunier 1978;Lee et al 1977;Taylor et al 1975;Tsukada et al 1975). Diese wird in der Literatur mit 17-43% angegeben.…”

Section: Mpaget Der Vulvaunclassified

Referat Präneoplasien der Vulva

Böcker¹,

Stegner²

1981

Arch. Gynecol.

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Angestrebtes Ziel einer Frtihdiagnostik maligner Tumoren ist die Erfassung obligater Krebsvorstufen (Burghardt 1972;Grundmann 1979; M/iller 1979; Seifert und Burkhardt 1979; Wellings und Price 1978). Wegweisend hierfiir sind die Erfolge an der Cervix uteri, wo mit relativ einfachen Methoden potentiell maligne Prozesse erkannt und effektiv therapiert werden k6nnen (Stegner 1973). Obwohl auch die Vulvakarzinome zu jenen Tumorformen geh6ren, die einer direkten Inspektion leicht zug~ingig sind, hinken unsere Kenntnisse fiber ihre Pr~ineoplasien aus einer Reihe von Gr/inden hinter denen der Zervix hinterher. Normale AnatomieDie Vulva stellt als Teil des Integuments eine komplizierte morphologisch-funktionelle Einheit ektodermaler, neuroektodermaler und mesenchymaler Bestandteile dar (Ackerman 1978). Topische Besonderheiten liegen in dem Reichtum an apokrinen Drtisen sowie in der Tatsache begriandet, dab es sich um ein Grenzgebiet zwischen Haut und Schleimhaut handelt. Entwicklungsgeschichtlich leiten sich Haut und Hautanhfinge von einem basalen Epithel ab. Aus diesem entstehen Epidermis sowie zwischen der 15. und 20. Embryonalwoche durch Aussprossung der Basalzellschicht Haarfollikel, Talgdrtisen sowie apokrine und ekkrine Schweil3drtisen. Die Melanozyten sind dagegen neuroektodermalen Ursprungs und bilden mit den basalen Keratinozyten die sogenannte ,,epidermale Melanin-Einheit".

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“…By contrast, vulvar Paget's disease with an underlying apocrine gland carcinoma has been regarded as an invasive malignancy and managed accordingly by a more radical treatment 1 . Moreover, vulvar Paget's disease in approximately 25% of the cases has been found to be associated with another prior or concomitant malignancy elsewhere in the body, especially breast carcinoma and squamous cell carcinoma of the vulva, uterus, cervix, and vagina 4 . Thus, screening procedures for these malignancies must become part of the routine evaluation of all patients with vulvar Paget's disease 5 …”

Section: Introductionmentioning

confidence: 99%

Vulvar Paget's Disease with an Underlying Sweat Gland Adenocarcinoma

Piura

Zirkin

1988

The Journal of Dermatologic Surgery and Oncology

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Vulvar Paget's disease, in contrast to its mammary counterpart, has been found to be associated with an underlying apocrine sweat gland carcinoma in about only 1/4 of the cases. There are two principal theories regarding the pathogenesis of extramammary Paget's disease: (1) intraepidermal origin of the Paget cells occurring independently of, or concomitantly with, an underlying apocrine gland carcinoma, and (2) the migration or metastasis of Paget cells into the epidermis from the underlying apocrine glands and/or ducts. A case of vulvar Paget's disease that, in our opinion, supports the theory of apocrine gland origin of Paget cells is reported herein.

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Extramammary Pagetʼs Disease

Cited by 38 publications

References 0 publications

Rapid Staining with Carcinoembryonic Antigen Aids Limited Excision of Extramammary Paget's Disease Treated by Mohs Surgery

Rapid Staining with Carcinoembryonic Antigen Aids Limited Excision of Extramammary Paget's Disease Treated by Mohs Surgery

Referat Präneoplasien der Vulva

Vulvar Paget's Disease with an Underlying Sweat Gland Adenocarcinoma

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