Extramammary paget's disease of the tongue

Pagetoid spread to oral mucosa from submandibular gland salivary duct carcinoma: a case report

“…This pattern is also observed in the extramammary region, such as the genital region, but is extremely rare in the oral mucosa. Only 2 previous case reports have described Paget disease of the oral mucosa [2,3]. We describe herein a rare type of carcinoma of the salivary gland.…”

Dedifferentiated Salivary Hybrid Carcinoma of the Maxillary Sinus with Pagetoid Spread to the Overlying Lining Mucosa

“…Pagetoid spread of neoplastic cells from a salivary carcinoma to the lining mucosa is a relatively rare phenomenon with only 3 cases previously described in the literature. In the first case, pagetoid spread of an underlying poorly differentiated adenocarcinoma to the tongue was described [21]. The illustrating photographs and histologic description were of such poor quality that a definitive classification of the adenocarcinoma was not possible.…”

“…Although dedifferentiation/high grade transformation has been described in a variety of malignant salivary gland tumors, this phenomenon has not been reported in salivary hybrid carcinoma [21,22]. Furthermore, while pagetoid spread of neoplastic cells from a malignant salivary gland tumor to the overlying lining mucosa has been documented in the oral mucosa [21][22][23], such an incidence has not been reported in the maxillary sinus. Herein, we describe an additional case of hybrid carcinoma of salivary glands in the maxillary sinus that demonstrated simultaneous occurrence of high-grade transformation and intraepithelial pagetoid spread to the overlying sinus mucosa.…”

“…To date, only a single case of salivary hybrid carcinoma has been observed in the maxillary sinus [14]. Although dedifferentiation/high grade transformation has been described in a variety of malignant salivary gland tumors, this phenomenon has not been reported in salivary hybrid carcinoma [21,22]. Furthermore, while pagetoid spread of neoplastic cells from a malignant salivary gland tumor to the overlying lining mucosa has been documented in the oral mucosa [21][22][23], such an incidence has not been reported in the maxillary sinus.…”

Extramammärer Morbus Paget – Klinik, Histogenese, Therapiemöglichkeiten

“…Zu weiteren Lokalisationen, in denen der Tumor allerdings nur ganz vereinzelt beschrieben werden konnte, zählen die Lider, der äußere Gehörgang, die Nabelregion, der Stamm und die Extremitäten [21][22][23][24][25][26][27]. In Einzelfällen wurde der EMP auch in verschiedenen Schleimhautlokalisationen (u. a. Zunge, Bronchien, Ösophagus und Urethra) beobachtet [25][26][27]. Ebenfalls als Rarität gelten multilokuläre Manifestationen des Tumors mammär und extramammär oder extramammär in verschiedenen Lokalisationen, z.…”