Extramedullary plasma cell tumors: Diagnosis by fine‐needle aspiration cytology

Das, Dilip K.; Gupta, Subhash K.; Sehgal, Shobha

doi:10.1002/dc.2840020318

Cited by 22 publications

(29 citation statements)

References 6 publications

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“…To date, only a few cases of GS diagnosed by FNAC have been reported in the literature [17, 18, 25, 29, 30, 31, 32, 33]. Clinically, GS has to be differentiated from an infectious …”

Section: Discussionmentioning

confidence: 99%

“…With the advent of fine-needle aspiration cytology (FNAC), the etiology of tumorous masses is relatively simple to determine without resorting to excisional biopsies. Surprisingly, there are only few cases reported in the literature on FNAC and GS [17, 18, 25, 29, 30, 31, 32, 33]. In this article, we report our experience with FNAC in determining the etiology of GS in 26 patients during a period of 10 years.…”

Section: Introductionmentioning

confidence: 97%

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Diagnosis of Granulocytic Sarcoma by Fine-Needle Aspiration Cytology

Bangerter¹,

Hildebrand²,

Waidmann³

et al. 2000

Acta Haematol

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Granulocytic sarcoma (GS) occurs in patients with chronic myeloproliferative disorders as well as in patients with acute myeloid leukemia (AML). These tumorous masses can occur anywhere in the body and have to be differentiated from lymphoma, carcinoma or infectious processes. We report the results of fine-needle aspiration cytology (FNAC) in 26 patients with GS. Seventeen patients suffered from AML and 9 from chronic myeloid leukemia (CML) blast crisis. In 5 patients with AML, GS was the initial presentation of hematological malignancy, in the remaining 21 patients, FNAC confirmed relapse of AML or extramedullary blast crisis of CML. In 8 patients, GS was located in the skin, in 17 in the lymph node and in another patient in the spinal canal. This study demonstrates the clinical utility and diagnostic accuracy of FNAC in the evaluation of GS from multiple sites.

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“…To date, only a few cases of GS diagnosed by FNAC have been reported in the literature [17, 18, 25, 29, 30, 31, 32, 33]. Clinically, GS has to be differentiated from an infectious …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Diagnosis of Granulocytic Sarcoma by Fine-Needle Aspiration Cytology

Bangerter¹,

Hildebrand²,

Waidmann³

et al. 2000

Acta Haematol

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“…Giant myeloma cells are a rare but well-described cell type in human MRD. 5,13,15 Giant myeloma cells can be mistaken for megakaryocytes but are seen in atypical sites, that is, they are noted outside of the bone marrow or typical sites of extramedullary hematopoesis. They have been associated with intermediate-grade and poorly differentiated tumors in human myeloma, 79 as was the case in the cats in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Myeloma cell origin may be deduced from antiimmunoglobulin immunolabeling. 5,13,15 As for cytologic description. An example may be seen in Fig.…”

Section: Giant Myeloma Cellmentioning

confidence: 99%

Histopathologic, Immunohistochemical, and Cytologic Analysis of Feline Myeloma-Related Disorders: Further Evidence for Primary Extramedullary Development in the Cat

et al. 2008

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Abstract. Feline myeloma-related disorders (MRD) are rare neoplasms of plasma cells. The multistep transformation model of myeloma in humans is based on the premise that plasma cells undergo neoplastic transformation primarily within the intramedullary compartment and that over time they become poorly differentiated and metastasize to extramedullary locations. Historically, diagnostic criteria used for human multiple myeloma have been applied to the cat, with the assumption that feline MRD commonly arises in the intramedullary compartment. Our objectives were to describe the features of feline MRD confirmed by cytology, histopathology, histochemistry, and immunohistochemistry and to categorize these tumors. A priori hypotheses were 1) tumor category predicts survival and 2) cats with well-differentiated tumors commonly have extramedullary involvement in contrast to human myeloma patients. This multicenter, retrospective study identified 26 MRD cases. There was good agreement between histopathologic and cytologic tumor categorization. Histochemistry and immunohistochemistry were shown to be valuable adjunct tests in the diagnosis of MRD. Cats with well-differentiated tumors had increased median survival relative to those with poorly differentiated tumors (254 versus 14 days). We have reported that marked extramedullary involvement at initial clinical presentation is significantly more common in the cat than in human MRD patients. In this study, we demonstrate that cats with welldifferentiated tumors more commonly have extramedullary involvement than human myeloma patients with well-differentiated tumors (90% versus 20%, P , 0.0002). These results contrast strongly with the human myeloma model of primary intramedullary neoplastic transformation and suggest that primary extramedullary neoplastic transformation may be more common in feline MRD.

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“…[11][12][13] Reports of FNAC in the diagnosis of extramedullary plasmacytoma are rare, and only a few reports are available with large numbers of cases studied. [14][15][16][17][18][19] The present article describes 18 patients with extramedullary plasmacytoma diagnosed by FNAC over a period of 10 years at our center.…”

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confidence: 99%