Extramedullary Plasmacytoma of the Nasal Cavity Report of Three Cases With Review of the Literature

Abstract

Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract. The nasal cavity and nasal septum are the most common sites of occurrence. In this report, three patients admitted in our clinic with history of nasal obstruction and/or epistaxis. Patients were diagnosed with extramedullary plasmacytoma and mass were completely excised. This entity usually occurred in 5th-6th decade of life. One of our patients, a young man, was completely asymptomatic and following a paroxysm of coughing, a polypoid mass was expectorated. The clinical and histopathologic findings of plasmacytoma are discussed. In order to exclude systemic involvement, systematic approach using clinical, laboratory, and radiologic investigations was performed. Extramedullary plasmacytoma of the nasal cavity is rare and should be considered in the differential diagnosis of nasal cavity masses especially in young age group.

Sinonasal extramedullary plasmacytoma: a population‐based incidence and survival analysis

“…SN‐EMP tends to present insidiously with nonspecific obstructive symptoms delaying timely diagnosis. Patients typically present in the 5th to 8th decade of life . Consistent with prior studies, we found a mean age at diagnosis of 61.3 years with a standard deviation of 15.9 years in our SN‐EMP cohort.…”

Extramedullary Plasmacytoma of the Paranasal Sinuses: Combining Surgery with External Radiotherapy

“…Soft tissue plasmacytoma has a significant sex-related susceptibility, with a mean male/ female ratio of 2.7. In this study males were more frequently affected, consistent with data previously reported [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

“…It accounts for 1 % of all head and neck malignant tumors. The most common sites of EMPs are the nose, paranasal sinuses, nasopharynx and tonsils, but it can also occur in the gastro-intestinal tract, CNS, urinary bladder, thyroid, testes, parotid gland and lymph nodes [3][4][5][6]. Men are more commonly affected, with a median age at diagnosis of 50-60 years.…”

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report

“…In our patient, this symptom was correlated with a benign lesion in the first observation and secondly, it was symptomatic of an ENP in early stage. In both observations, the patient never presented any other symptoms associated with the nasal obstruction such as epistaxis (12,13), rhinorrhea (12), anosmia (13), nasal discharge (12,13) or sudden episode of obstructive sleep apnea syndrome (14). These symptoms have been widely described in patients affected from nasal cancer (12)(13)(14).…”