Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

Carneiro, Fabiana Pirani; Sobreira, Maria de Nazareth; Maia, Livia Bravo; Sartorelli, Alesso Cervantes; Franceschi, Luiz Eduardo de Almeida Prado; Brandao, M.; Calaça, Bárbara Wosnjuk; Lustosa, Fernando Silva; Lopes, João Vieira

doi:10.3748/wjg.15.3565

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…In a previous clinical study concerning either cases of CNS-MM or other extramedullary sites of localization of MM, immunocytochemical techniques were applied, with the evidence of substantial lack of CD56 expression. 21,[34][35][36][37][38][39][40] The hypothesis that CD56 down-regulation might favor the migration of MM plasma cells from the bone marrow was put forward.…”

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confidence: 99%

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Marini

Carulli

Lari

et al. 2014

J Clin Exp Hematopathol

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Central nervous system (CNS) involvement in multiple myeloma (MM) is uncommon. Among its possible presentations, leptomeningeal involvement of MM, also termed central nervous system myelomatosis (CNS-MM) is rare and is characterized by the presence of neoplastic plasma cells in the cerebrospinal fluid (CSF). So far, 187 cases of CNS-MM have been reported : the great majority of them were diagnosed by cytological assays and flow cytometry was used in only eight cases. We describe a case of CNS-MM in a 62-year-old woman, previously treated with chemotherapy (VTD) and autologous peripheral blood hematopoietic stem cell transplantation for stage IIIB IgG-l MM. After achieving a very good partial response, the patient showed progression of disease, with an extramedullary localization. During administration of second-line therapy, the patient showed severe neurological symptoms. MRI resulted negative. Diagnosis of CNS-MM was made by multiparameter flow cytometry, which showed the presence of CD56 + plasma cells in a CSF sample, in the absence of plasma cell leukemia. In this paper we also present a review of the eight previous cases of CNS-MM diagnosed by flow cytometry. We found that the application of flow cytometry in cases of MM with neurological symptoms allows a rapid diagnosis of CNS-MM and provides useful information about plasma cell phenotype (including CD56 expression). Some cases of CNS-MM are characterized by normal MRI. In addition, some evidences deriving from the review of literature suggest that CSF monitoring by flow cytometry in such cases might be used to evaluate the efficacy of drugs capable of crossing the blood-brain barrier. 〔J Clin Exp Hematop 54 (2) : 129-136, 2014〕

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confidence: 99%

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Marini

Carulli

Lari

et al. 2014

J Clin Exp Hematopathol

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“…Amyloid deposition may be seen in 15 to 38% of extramedullary plasmacytoma. In a case report of extramedullary plasmacytoma of duodenum, 5 amyloidosis was caused by the deposition of immunoglobulin light chains since both amyloid and plasma cells share the same immunoglobulin light chain restriction (lambda restriction). In our case, there was no feature of amyloidosis.…”

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confidence: 99%

Extramedullary Plasmacytoma of Nasal Cavity

Meher¹,

Tandon²

2016

An International Journal Clinical Rhinology

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Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells in soft tissues. Extramedullary plasmacytomas constitute 3 to 5% of all plasma cell neoplasms. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract, with 75% occurring in nose and paranasal sinuses. To the best of our knowledge, only few cases of sinonasal extramedullary plasmacytomas have been reported in the literature. It is important for otolaryngologists to acquire knowledge of this disease as 80 to 90% occur in the head and neck region. We report a rare case of extramedullary plasmacytoma of the nasal cavity in a 60-year-old male managed by surgery and radiotherapy. How to cite this article Tandon S, Meher R, Chauhan A. Extramedullary Plasmacytoma of Nasal Cavity. Clin Rhinol An Int J 2016;9(1):50-52.

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“…It is well‐known that extramedullary plasmacytoma is occasionally associated with amyloidosis that is derived from excessive light chain produced by neoplastic plasma cells . MALT lymphomas with striking plasma cell differentiation can reveal amyloid deposition.…”

Section: Discussionmentioning

confidence: 99%

Cytologic findings and differential diagnoses of primary thyroid MALT lymphoma with striking plasma cell differentiation and amyloid deposition

Nobuoka

Hirokawa

Kuma

et al. 2013

Diagnostic Cytopathology

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We report two cases of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma with associated amyloid protein deposition. While other primary thyroid neoplasms sush as medullary carcinoma and plasmacytoma with associated amyloid protein are known to occur and have been previously described by fine-needle aspiration cytology (FNAC), to our knowledge, the current cases are the first of thyroid MALT lymphoma with amyloid deposition to be detailed in the cytopathology literature. Case 1 was a 73-year-old female with chronic thyroiditis. FNAC suspected MALT lymphoma. The amyloid material was not noticed, nevertheless it existed. Case 2 was a 71-year-old female with a nodule of the thyroid. Malignant lymphoma and medullary carcinoma were suspected by FNAC. The possibility of medullary carcinoma was excluded by a measurement of serum calcitonin and carcinoembryonic antigen. After follow-up for two years, the nodule was diagnosed as MALT lymphoma associated with plasma cell differentiation and amyloidosis by the fourth FNAC. When we encounter small round cell tumors associated with amyloid in thyroid FNAC, we should consider not only medullary carcinoma but also MALT lymphoma.

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Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

Cited by 10 publications

References 17 publications

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Extramedullary Plasmacytoma of Nasal Cavity

Cytologic findings and differential diagnoses of primary thyroid MALT lymphoma with striking plasma cell differentiation and amyloid deposition

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