Extranodal lymphoma originating in the gluteal muscle with adjacent bone involvement and mimicking a soft tissue sarcoma

Katsura, Morihiro; Nishina, Hirokazu; Shigemori, Yasushi; Nakanishi, Takaya

doi:10.1016/j.ijscr.2015.01.024

Cited by 11 publications

(17 citation statements)

References 20 publications

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“…The most common site of involvement is the extremities, with psoas, calf, gluteal, triceps muscle invasion being described in the literature. [ 2 , 3 , 5 , 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…CT scan may reveal a hypodense or isodense mass, muscle swelling, disruption and injury of the surrounding tissues, periosteal reaction, and sequestration. [ 2 , 3 , 6 ] On MRI, muscle infiltration demonstrates an increased signal intensity on T1-weighted images, intermediate signal intensity compared with fat on T2-weighted images, and homogenous diffuse enhancement when contrast material is used. This specific radiographic evidence assists in the differential diagnosis of muscle lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 , 7 ] PET/CT is the preferred method for staging, treatment efficacy assessment, and possible extranodal disease detection or exclusion. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

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Isolated skeletal muscle recurrence of an originally nodal diffuse large B cell lymphoma

Spetsieris¹,

Giannakopoulou²,

Variami³

et al. 2018

Medicine

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Rationale:Diffuse large B cell lymphoma (DLBCL) is a malignancy of the B cells with extranodal primary involvement being estimated at 30% to 40% of cases. Primary skeletal muscle presentation of DLBCL is extremely rare, with an estimated incidence of about 0.5% of extranodal lymphomas, presenting mostly in the lower extremities. The possible mechanisms of muscle involvement of DLBCL include primary extranodal disease, extension from adjacent organs (such as lymph nodes) or disseminated disease.Patient concerns:We report a case of a 70-year-old woman with an advanced initially nodal DLBCL, treated with R-CHOP, that presented with an enlargement of her left thigh and restricted mobility 3 months after completion of chemotherapy. Imaging studies were performed, which showed possible infiltration of the muscles of the left thigh, without any nodal disease present.Diagnoses:Muscle biopsy documented the recurrence of the lymphoma at the left thigh.Interventions:The patient started second-line treatment with gemcitabine and vinorelbine.Outcomes:A partial response was achieved after the first cycle.Lessons:The remarkable element lies in the reappearance of the lymphoma at the left thigh muscles, with no radiographic or clinical evidence of involvement of lymph nodes, despite the extensive lymph node disease at initial presentation. The further management of such recurrences remains to be clarified, as the odd biological behavior of the malignant cells dictates a special handling of the disease.

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“…The most common site of involvement is the extremities, with psoas, calf, gluteal, triceps muscle invasion being described in the literature. [ 2 , 3 , 5 , 6 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Isolated skeletal muscle recurrence of an originally nodal diffuse large B cell lymphoma

Spetsieris¹,

Giannakopoulou²,

Variami³

et al. 2018

Medicine

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“…The soft tissue involvement is more common in NHL rather than Hodgkin's lymphoma [18]. There are several theories put forward suggesting the cause of primary soft tissue lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Diffuse B Cell Non-Hodgkin’s Lymphoma Presenting Atypically as Periprosthetic Joint Infection in a Total Hip Replacement

Rajeev

Ralte

Choudhry

et al. 2017

Case Reports in Orthopedics

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The occurrence of extranodal primary B cell non-Hodgkin's lymphoma is rare. Total hip replacement is one of the most common orthopaedic procedures performed. There has been an increased incidence of primary lymphomas involving periprosthetic sites. Chronic inflammation due to metal debris arising from the prosthetic implants has been evidenced as one of the causes for the development of soft tissue lymphomas albeit rarely. We describe a case report of a 77-year-old patient who had underwent a cemented total hip replacement in the past who further developed large B cell primary non-Hodgkin's lymphoma. She presented initially with signs and symptoms highly suggestive of underlying periprosthetic infection. The radiological imaging was also indicative of periprosthetic infection. The diagnosis was eventually confirmed after an open biopsy. This case underlines the importance of considering and including soft tissue malignancy in the differential diagnosis of suspected chronic periprosthetic infection.

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“…Patients with extranodal NHL present more frequently with early stage disease compared with those with nodal NHL; overall survival in both groups largely depends on IPI (international prognostic index) and not on the site of origin of the malignancy [ 41 ]. Hence, although cases of primary skeletal DLBCL may be undertreated overall, if diagnosed early and correctly patients have a likelihood to achieve complete response upon treatment with R-CHOP [ 5 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Extranodal Diffuse Large B-Cell Lymphoma Infiltrating Skeletal Muscle: A Case Report and Review of the Literature

Hatem

Bogusz

2016

Case Reports in Pathology

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Diffuse large B-cell lymphoma is extranodal in approximately 40% of cases, arising in nearly any organ system. DLBCL involvement of soft tissue and in particular skeletal muscle is extremely rare, comprising less than 1% of all extranodal non-Hodgkin lymphomas (NHL). We report a case of a 79-year-old man that presented with a DLBCL of the left triceps. In particular, we describe an unusual histologic appearance of pseudoglandular structures, resembling adenocarcinoma. We performed a review of lymphoma cases involving skeletal muscle diagnosed at our institution over the past 15 years as well as thorough PubMed review of the literature. We discuss the features of lymphoma involving skeletal muscle as it pertains to clinical characteristics, histologic subtype, tumor localization, diagnostic studies, therapy, and outcome. Finally, we highlight the diagnostic difficulties that can present in these rare and often challenging cases.

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Extranodal lymphoma originating in the gluteal muscle with adjacent bone involvement and mimicking a soft tissue sarcoma

Cited by 11 publications

References 20 publications

Isolated skeletal muscle recurrence of an originally nodal diffuse large B cell lymphoma

Isolated skeletal muscle recurrence of an originally nodal diffuse large B cell lymphoma

Diffuse B Cell Non-Hodgkin’s Lymphoma Presenting Atypically as Periprosthetic Joint Infection in a Total Hip Replacement

An Unusual Case of Extranodal Diffuse Large B-Cell Lymphoma Infiltrating Skeletal Muscle: A Case Report and Review of the Literature

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