Extraösophageale Manifestationen der Refluxkrankheit: eine kritische Analyse

Labenz, Joachim

doi:10.1055/s-0029-1237516

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Gastro-esophageal reflux disease (GERD) is a categorical disease that displays itself in three diverse phenotypes that represent different disorders: non-erosive esophagitis, erosive esophagitis and Barrett's esophagus (BE) (Dent et al, 2005;Labenz, 2009). It has been reported that the pathogeneses of GERD, BE and cancer are multifactorial and complex (Boeckxstaens et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus

Lehleh

Ellaithy

Zahran

et al. 2021

International Journal of Cancer and Biomedical Research

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Background: Obesity especially visceral obesity is an important independent risk factor for the development of gastro-esophageal reflux disease (GERD) and, Barrett's esophagus (BE). Aim: In this work, we aimed to evaluate serum adiponectin level in obese patients with GERD and Barrett's oesophagus as well as highlight its role in early predicting Barrett's oesophagus. Materials and Method: 120 participants with BMI ≥ 25 were involved in this case control study. They were grouped into Group I: 30 participants of coincided BMI, age and gender as obese controls; Group II: included 60 patients with GERD, and Group III: 30 patients with BE. All participants were subjected to clinical evaluation, Upper endoscope and serum adiponectin by ELISA. Biopsy with histopathological evaluation to confirm BE was done. Results: Significantly lower plasma adiponectin levels were detected in BE patients compared to GERD patients and the control group with significantly higher plasma adiponectin levels in GERD compared to controls. ROC analysis showed that AUC was 0.958 at a cut-off point ≤ 0.74, sensitivity and specificity were (90.0% and 95.0% respectively) for prediction of BE in GERD patients. Lower adiponectin levels were found in patients with large sliding hiatus hernia, longsegment Barrett as well as patients with high-grade dysplasia. Multivariate analysis displayed that adiponectin could be an independent predictor for BE. Conclusion: Obesity is a substantial risk for the development of GERD and BE. Adequate weight control is an important step for the prevention of BE. Additionally, adiponectin serum levels could be a reliable non-invasive biomarker for early prediction of BE.

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Section: Introductionmentioning

confidence: 99%

Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus

Lehleh

Ellaithy

Zahran

et al. 2021

International Journal of Cancer and Biomedical Research

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“…GERD is a categorical disease that manifests itself in three distinct ways: non‐erosive or erosive esophagitis and Barrett's esophagus 2. The underlying mechanism of GERD is thought to be mechanically related to an increase in intragastric pressure due to the external compression of surrounding adipose tissue resulting in the frequent relaxation of the lower esophageal sphincter and hence the development of mucosal damage in the esophagus due to pathological acid reflux 3.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

et al. 2018

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Background and AimVisceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.MethodsIn this study, 150 subjects were selected and divided into four groups: Group І (n = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ (n = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ (n = 40) were patients with severe erosive esophagitis; and finally, Group ІV (n = 20) were patients with Barrett's esophagus. Upper gastrointestinal endoscopy was performed for Groups II, III, and IV only, and histopathological assessment was conducted for the suspicious cases of Barrett's esophagus. The measurement of serum adiponectin was performed for all groups using the ELISA test.ResultsOur results revealed that the serum level of adiponectin was significantly lower in patients with different grades of GERD as well Barrett's esophagus as compared to healthy controls (P‐value < 0.001). Additionally, the serum level of adiponectin was correlated with different grades of GERD as the highest level of the adiponectin was found in the control group (11.05 ± 2.58) followed by mild to moderate GERD (6.39 ± 1.64) and then severe GERD (2.42 ± 1.00); finally, the lowest level was detected in the Barrett's esophagus group (1.99 ± 0.47). Our study showed significant correlation between body mass index, waist circumference, and waist–hip ratio on one hand and serum adiponectin level on the other hand, with a statistically significant difference (P‐value < 0.001). The best cut‐off value for serum adiponectin was 7.7 (μg/mL), with a sensitivity of 91.8% and specificity of 97.5%.ConclusionsLow serum adiponectin level appears to be associated with an increased risk of erosive esophagitis, and visceral fat accumulation is related to the impaired secretion of adiponectin, which may have an influence on the pathogenesis of GERD.

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Entzündliche Erkrankungen der Speiseröhre

Koop

Schumacher

2015

Viszeralmedizin

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Extraösophageale Manifestationen der Refluxkrankheit: eine kritische Analyse

Cited by 5 publications

References 16 publications

Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus

Role of serum Adiponectin level in assessment of obese patients with Barrett's esophagus

Adiponectin level changes among Egyptians with gastroesophageal reflux disease

Entzündliche Erkrankungen der Speiseröhre

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