Extrapleural solitary fibrous tumor of the thyroid gland: A case report and review of literature

Suh, Yong Joon; Park, Jung Ho; Jeon, Jae Hyeon; Bilegsaikhan, Sanchir-Erdene

doi:10.12998/wjcc.v8.i4.782

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…To validate the proliferation of CD8 + T-cells, we employed the Ki-67 antibody as an immunofluorescence staining marker. 34 The aP/IR@FMKB-based multimodal therapy prominently enhanced the proliferation of CD8 + T-cells, as evidenced by 82.63% of Ki-67-positive cells among the CD8 + T-cell population ( Figure 6C ). Moreover, this multimodal therapy also augmented the presence of tumor necrosis factor α (TNF-α) and interferon-γ (IFN-γ) dual-positive CTLs by 4.0-fold compared to the PBS group ( Figure 6D ).…”

Section: Resultsmentioning

confidence: 90%

MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy

Zhang,

Hu,

Guo

et al. 2024

IJN

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Introduction Responsive drug delivery systems hold great promise for tumor treatment as they focus on therapeutic agents directly, thus minimizing systemic toxicities and drug leakage. In this study, we covalently bound a matrix metalloproteinases-2 (MMP-2) enzyme-sensitive peptide to a tissue-penetrating peptide to rationally design a MMP-2 responsive multifunctional peptide hydrogel platform (aP/IR@FMKB) for cancer photothermal-chemo-immunotherapy. The constructed aP/IR@FMKB with bufalin (BF) loaded in trimethyl chitosan nanoparticles (TB NPs), photothermal agent IR820, and immune checkpoint inhibitor aPD-L1 by self-assembly could be dissociated in the presence of MMP-2 enzyme, triggering content release. Methods TB NPs, IR820, and aPD-L1 were encapsulated by intermolecular self-assembly and enzyme-sensitive nanogels (aP/IR@FMKB) were constructed. The in vitro cytotoxicity of the blank gels and their ability to induce immunogenic cell death (ICD) in aP/IR@FMKB were evaluated using 4T1 cells. The promotion of deep tumor penetration and enzyme responsiveness was analyzed using a 3D cell model. The retention and antitumor activity at the tumor sites were examined using the primary tumor model. To assess the antitumor effect of aP/IR@FMKB induced by the immune response and its mechanism of action, recurrent tumor and distal tumor models were constructed. Results This hydrogel system demonstrated exceptional photothermal performance and displayed prolonged local retention. Furthermore, the induction of ICD through IR820 and TB NPs sensitized the PD-L1 blockade, resulting in a remarkable 3.5-fold and 5.2-fold increase in the frequency of intratumor-infiltrating CD8 + T-cells in the primary tumor and distal tumor, respectively. Additionally, this system demonstrated remarkable efficacy in suppressing primary, distal, and recurrent tumors, underscoring its potential as a highly potent therapeutic strategy. Conclusion This innovative design of the responsive hydrogel can effectively modulate the tumor immune microenvironment while also demonstrating sensitivity to the PD-1/PD-L1 blockade. This significant finding highlights the promising potential of this hydrogel in the field of multimodal tumor therapy.

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Section: Resultsmentioning

confidence: 90%

MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy

Zhang,

Hu,

Guo

et al. 2024

IJN

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“…An SFT of the thyroid gland can be difficult to distinguish from other tumors, such as anaplastic carcinomas, hemangiopericytomas, medullary carcinomas, sarcomas, leiomyomas, neurofibromas, schwannomas, and Riedel's thyroiditis. [7,10,14,15] A diagnosis of an SFT of the thyroid gland can only be made after the exclusion of other thyroid tumors that exhibit spindle-cell morphology. [16] SFTs of the thyroid gland have a distinct morphology that is often referred to as a "patternless" pattern, showing spindle cell growth interspersed with hypercellular and hypocellular patches.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In this review of literature, we examined the clinical signs, imaging characteristics, differential diagnosis, histology, immunohistochemistry, treatment, and prognosis (Table 1). [4][5][6][7][8] The age range of the reported patients (19 women and 24 men) was 28 to 88 years (mean age: 54.5 years), and the diameter of the neoplasm ranged from 23 to 138 mm (mean diameter: 58 mm). The SFT was located in the right lobe in 15 cases and the left lobe in 20 cases; however, its location was not reported in 5 cases.…”

Section: Literature Reviewmentioning

confidence: 99%

“…In this review of literature, we examined the clinical signs, imaging characteristics, differential diagnosis, histology, immunohistochemistry, treatment, and prognosis (Table 1). [4–8]…”

Section: Literature Reviewmentioning

confidence: 99%

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A case report of solitary fibrous tumor of the thyroid gland and literature review

Zhang,

Han,

Zhao

et al. 2023

Medicine

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Rationale: A solitary fibrous tumor (SFT) is an uncommon soft tissue tumor that was first discovered in the pleura. Although SFTs have been documented in other extra-pleural sites, an SFT in the thyroid gland is highly unusual. An SFT of the thyroid gland can be difficult to diagnose, and there is little information about their Underlying biological behavior. Patient concerns: We present a case of a 63-year-old man with a progressively growing left-neck mass detected 1 month ago, which was pathologically confirmed to be a benign SFT of the thyroid gland. Diagnosis: Postoperative pathological examination of the tumor revealed an SFT. Immunopathological examination was consistent with the diagnosis of an SFT. Interventions: The patient underwent surgical resection of the SFT. Outcomes: The patient was recurrence-free during 1.5 years of follow-up. Lessons: Surgical excision is beneficial in SFTs that show no histological signs of malignancy, such as pleomorphism, enhanced mitotic activity, necrosis, bleeding, or capsular invasion. However, because the biologic activity remains unknown, meticulous long-term monitoring is required.

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Primary Mesenchymal Tumors of the Thyroid

Hu,

Kassu,

Kebebew

2023

Practical Management of Thyroid Cancer

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Extrapleural solitary fibrous tumor of the thyroid gland: A case report and review of literature

Cited by 9 publications

References 31 publications

MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy

MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy

A case report of solitary fibrous tumor of the thyroid gland and literature review

Primary Mesenchymal Tumors of the Thyroid

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