Extrarenale und extrapulmonale Befunde beim Goodpasture-Syndrom

Kamanabroo, D.; Loew, H; Witting, Ch.; Intorp, H. W.; Burger, G

doi:10.1007/978-3-642-85453-8_321

Cited by 1 publication

(4 citation statements)

References 13 publications

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“…Jampol et al |5| reported 2 cases with serous retinal detach ments in which anti-GBM antibody was shown by immu nofluorescence and immunohistochcmistry to bind to the basement membrane of the ciliary epithelium and Bruch's membrane, anil Kamanabroo et al [7] reported linear dis tribution o f immunoglobulin G in the uvea. Pusey et al |13] showed binding of a monoclonal antibody to the human GBM to basement membranes in the choroid, retina and lens capsule as well as certain other tissues.…”

Section: Discussionmentioning

confidence: 99%

“…or inter chain cross-linking between collagen molecules and the other constituents of basement membranes (laminin, pro teoglycans and entactin) [17] could interfere with binding. Alternatively, it m aybe that antigen-antibody binding is not pathogenic at this site: in the case where linear binding of IgG was demonstrated in the uvea [7], no abnormality was visible by ordinary light microscopy. In contrast, in the 2 cases where anti-GBM antibody was shown bound to the ciliary epithelium and Bruch's membrane [3], light micros copy revealed fibrinoid occlusion of the choriocapillaris and necrosis of the retinal pigment epithelium, together with choroidal haemorrhage, and electron microscopy showed ultrastruclural changes in basement membranes.…”

Section: Discussionmentioning

confidence: 99%

“…Scleritis also occurs [7], but this inflammatory condition is difficult to attribute to anti-basement-membrane anti bodies. Other ophthalmic disorders, including conjuncti vitis [7], glaucoma [8] and orbital pseudotumour [9], are not likely to be aetiologically related to Goodpasture's syn drome.…”

Section: Introductionmentioning

confidence: 99%

“…Of these, serous retinal detachments could be caused by the effects of anti-basement-membrane anti bodies [5], while retinal vascular abnormalities with isch aemia could also be caused by hypertension or anaemia [6]. Scleritis also occurs [7], but this inflammatory condition is difficult to attribute to anti-basement-membrane anti bodies. Other ophthalmic disorders, including conjuncti vitis [7], glaucoma [8] and orbital pseudotumour [9], are not likely to be aetiologically related to Goodpasture's syn drome.…”

Section: Introductionmentioning

confidence: 99%

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Ophthalmic Features of Fourteen Cases of Goodpasture’s Syndrome

Rowe¹,

Mansfield

Dutton

1994

Nephron

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Juxtapapillary subretinal neovascular membranes developed in both eyes of a patient who had been treated for Goodpasture’s syndrome for 4 years. These lesions caused visual impairment but were successfully treated by laser photocoagulation. Subretinal neovascularisation has not been reported before in association with Goodpasture’s syndrome, but diverse ocular abnormalities have been described. It is not certain whether these lesions were caused by anti-basement-membrane auto-antibodies. The eyes of 13 other patients with Goodpasture’s syndrome were examined, in order to detect other unsuspected ocular pathology. In 1 further patient, both retinae contained a few unexplained superficial retinal haemorrhages. During follow-up, the original patient developed bilateral peripheral retinoschisis. From this short series and from cases previously described, we conclude that sight-threatening ocular abnormalities are rare in Goodpasture’s syndrome. It is, however, particularly important to be aware of the possibility of treatable eye disease in Goodpasture’s syndrome, since the introduction of effective treatment with immunosuppression and plasmapheresis has made long-term survival likely.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%