Ophthalmic Features of Fourteen Cases of Goodpasture’s Syndrome

Abstract

Juxtapapillary subretinal neovascular membranes developed in both eyes of a patient who had been treated for Goodpasture’s syndrome for 4 years. These lesions caused visual impairment but were successfully treated by laser photocoagulation. Subretinal neovascularisation has not been reported before in association with Goodpasture’s syndrome, but diverse ocular abnormalities have been described. It is not certain whether these lesions were caused by anti-basement-membrane auto-antibodies. The eyes of 13 other patients with Goodpasture’s syndrome were examined, in order to detect other unsuspected ocular pathology. In 1 further patient, both retinae contained a few unexplained superficial retinal haemorrhages. During follow-up, the original patient developed bilateral peripheral retinoschisis. From this short series and from cases previously described, we conclude that sight-threatening ocular abnormalities are rare in Goodpasture’s syndrome. It is, however, particularly important to be aware of the possibility of treatable eye disease in Goodpasture’s syndrome, since the introduction of effective treatment with immunosuppression and plasmapheresis has made long-term survival likely.

The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

“… 16 Similar linear IgG deposition on Bruch’s membrane has been reported in patients with anti-GBM disease who developed concurrent choroidal ischemia and retinal detachment. 17 , 18 …”

“…16 Similar linear IgG deposition on Bruch's membrane has been reported in patients with anti-GBM disease who developed concurrent choroidal ischemia and retinal detachment. 17,18 The arrangement of the choroidal capillary (choriocapillaris) endothelium, Bruch's membrane, and retinal pigment epithelium mirrors that of the glomerular endothelium, GBM, and podocyte ( Figure 2). The pathological relevance of this homology is readily appreciated in membranoproliferative glomerulonephritis type II, in which electron dense deposits are found on the GBM and on Bruch's membrane.…”

Acute Ocular Complications after Recently Diagnosed Goodpastureʼs Syndrome – An Unusual Case of Hypertensive Retinopathy

“…Thirty years later, Lommatzsch et al described hypertensive retinopathy with cotton wool spots, hard exudates, and hemorrhages related to GS in a 22year-old man [7]. Other ocular findings, such as serous retinal detachment and choroidal neovascular membranes, are also described in the literature [10,12,13]. In 1975, Jampol et al described two cases of central retinal detachment in association with malignant hypertension due to GS.…”

Choroidal involvement in systemic vasculitis: a systematic review

“…While fibrinoid occlusion of the choriocapillaris and necrosis of the RPE, together with choroidal hemorrhage have been shown in light microscopy, electron microscopy revealed ultrastruc-Özdal and Tugal-Tutkun Journal of Ophthalmic Inflammation and Infection (2022) 12:14 tural changes in basement membranes. Although not proven with biopsy, a case with bilateral choroidal neovascular membrane associated with anti-GBM disease has been reported [81]. Cryoglobulinemic vasculitis (CV) is characterized by cryoglobulin immune deposits affecting small vessels and associated with cryoglobulins in the serum.…”